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chrm1a cholinergic receptor, muscarinic 1a [ Danio rerio (zebrafish) ]

Gene ID: 792708, updated on 27-Mar-2024

Summary

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Official Symbol
chrm1aprovided by ZNC
Official Full Name
cholinergic receptor, muscarinic 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-090410-9
See related
Ensembl:ENSDARG00000037292 AllianceGenome:ZFIN:ZDB-GENE-090410-9
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable G protein-coupled acetylcholine receptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in postsynaptic membrane. Predicted to be integral component of plasma membrane. Is expressed in eye. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome; asthma; and myasthenia gravis. Orthologous to human CHRM1 (cholinergic receptor muscarinic 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 14
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (24258622..24262791)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (23961377..23965546)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene NK2 homeobox 5 Neighboring gene BCL2 interacting protein 1a Neighboring gene D4, zinc and double PHD fingers family 2, like Neighboring gene uncharacterized LOC107195253 Neighboring gene heterogeneous nuclear ribonucleoprotein A0a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Pharmaceutical Assessment Suggests Locomotion Hyperactivity in Zebrafish Triggered by Arecoline Might Be Associated with Multiple Muscarinic Acetylcholine Receptors Activation. Siregar P, et al. Toxins (Basel), 2021 Apr 3. PMID 33916832, Free PMC Article
  2. Developmental expression of muscarinic receptors in the eyes of zebrafish. Nuckels RJ, et al. Brain Res, 2011 Aug 8. PMID 21741623
  3. Evolution of the Muscarinic Acetylcholine Receptors in Vertebrates. Pedersen JE, et al. eNeuro, 2018 Sep-Oct. PMID 30564629, Free PMC Article
  4. Cloning and characterization of muscarinic receptor genes from the nile tilapia (Oreochromis niloticus). Seo JS, et al. Mol Cells, 2009 Mar 31. PMID 19326086
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled acetylcholine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
muscarinic acetylcholine receptor M3-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    24258622..24262791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001332257.7 → XP_001332293.3  muscarinic acetylcholine receptor M3-like

    UniProtKB/TrEMBL
    A0A8M1Q6V1
    Related
    ENSDARP00000142274.1, ENSDART00000173227.2
    Conserved Domains (2) summary
    pfam00001
    Location:16 → 408
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:7 → 195
    7tm_4; Olfactory receptor
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials