Format

Send to:

Choose Destination

THOC6 THO complex 6 [ Homo sapiens (human) ]

Gene ID: 79228, updated on 8-May-2016
Official Symbol
THOC6provided by HGNC
Official Full Name
THO complex 6provided by HGNC
Primary source
HGNC:HGNC:28369
See related
Ensembl:ENSG00000131652 HPRD:14504; MIM:615403; Vega:OTTHUMG00000177451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BBIS; WDR58; fSAP35
Orthologs
Location:
16p13.3
Exon count:
13
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (3024031..3027755)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3074032..3077756)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene claudin 6 Neighboring gene tumor necrosis factor receptor superfamily member 12A Neighboring gene host cell factor C1 regulator 1 Neighboring gene BICD family like cargo adaptor 2 Neighboring gene uncharacterized LOC100128770 Neighboring gene uncharacterized LOC105371057 Neighboring gene matrix metallopeptidase 25 Neighboring gene MMP25 antisense RNA 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of THO complex 6 homolog (THOC6) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, THO complex 6 homolog (THOC6), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with THOC6 is decreased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC2655

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA export from nucleus TAS
Traceable Author Statement
more info
 
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
central nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA 3'-end processing TAS
Traceable Author Statement
more info
 
mRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
termination of RNA polymerase II transcription TAS
Traceable Author Statement
more info
 
viral mRNA export from host cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
THO complex IDA
Inferred from Direct Assay
more info
PubMed 
THO complex part of transcription export complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with nuclear chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription export complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
THO complex subunit 6 homolog
Names
THO complex 6 homolog
WD repeat domain 58
WD repeat-containing protein 58
functional spliceosome-associated protein 35

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142350.1NP_001135822.1  THO complex subunit 6 homolog isoform 2

    See identical proteins and their annotated locations for NP_001135822.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC108134, AK075330, BG613317, BM457458
    Consensus CDS
    CCDS45392.1
    UniProtKB/Swiss-Prot
    Q86W42
    Related
    ENSP00000253952, OTTHUMP00000256698, ENST00000253952, OTTHUMT00000436987
    Conserved Domains (2) summary
    COG2319
    Location:27266
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:31265
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_024339.3NP_077315.2  THO complex subunit 6 homolog isoform 1

    See identical proteins and their annotated locations for NP_077315.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC050674, BG613317, BM457458
    Consensus CDS
    CCDS10491.1
    UniProtKB/Swiss-Prot
    Q86W42
    Related
    ENSP00000326531, OTTHUMP00000256695, ENST00000326266, OTTHUMT00000436981
    Conserved Domains (2) summary
    COG2319
    Location:27274
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:27285
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    3024031..3027755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    3073906..3077630
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)