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    BAG6 BCL2-associated athanogene 6 [ Homo sapiens ]

    Gene ID: 7917, updated on 11-May-2012
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    Summary

    Official Symbol
    BAG6provided by HGNC
    Official Full Name
    BCL2-associated athanogene 6provided by HGNC
    Primary source
    HGNC:13919
    Locus tag
    DADB-70P7.10-021
    See related
    Ensembl:ENSG00000204463; HPRD:00808; MIM:142590; Vega:OTTHUMG00000031171
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G3; BAT3; BAG-6; D6S52E
    Summary
    This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    6p21.3
    Sequence :
    Chromosome: 6; NC_000006.11 (31606805..31620477, complement)
    See BAG6 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene allograft inflammatory factor 1 Neighboring gene proline-rich coiled-coil 2A Neighboring gene small nucleolar RNA, H/ACA box 38 Neighboring gene apolipoprotein M Neighboring gene chromosome 6 open reading frame 47

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. BAT3 guides misfolded glycoproteins out of the endoplasmic reticulum. Claessen JH, et al. PLoS One, 2011. PMID 22174835.
    2. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    3. γ-Interferon-regulated chaperone governs human lymphocyte antigen class II expression. Kämper N, et al. FASEB J, 2012 Jan. PMID 21940994.
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    5. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Li S, et al. Immunity, 2011 Sep 23. PMID 21903422.

    See all (71) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. BAT3, a cytosolic chaperone, is recruited to the site of dislocation through its interaction with Derlin2.
      Title: BAT3 guides misfolded glycoproteins out of the endoplasmic reticulum.
    2. We present a mechanism explaining how parallel IFNgamma-mediated regulation of CIITA and of its chaperone BAT3 controls the level of components of the HLA class II processing pathway.
      Title: γ-Interferon-regulated chaperone governs human lymphocyte antigen class II expression.
    3. Results suggest BAT2 -8671, BAT3 8854, and BAT5 22655, 9569 SNPs as well as BAT haplotypes (ATTGTG and ATCATG) might be associated with higher Kawasaki disease susceptibility and coronary artery aneurysm formation.
      Title: Human lymphocyte antigen B-associated transcript 2, 3, and 5 polymorphisms and haplotypes are associated with susceptibility of Kawasaki disease and coronary artery aneurysm.
    4. Data suggest that BAG-6 is necessary for ubiquitin-mediated degradation of newly synthesized defective polypeptides.
      Title: BAG-6 is essential for selective elimination of defective proteasomal substrates.
    5. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    6. The HSP70-driven degradation of BAG6, following the BAG6-dependent accumulation of HSP70, could allow the protein-refolding activity of HSP70 and limit the extent of its induction.
      Title: Sequential interplay between BAG6 and HSP70 upon heat shock.
    7. colocalization of PBF and Scythe/BAT3 in the nucleus might be an important factor for survival of osteosarcoma cells.
      Title: Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma.
    8. NKp30-mediated NK cells/dendritic cells cross talk resulting either in iDC killing or maturation was BAT3-dependent
      Title: Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function.
    9. BORIS acts as a platform upon which BAT3 and SET1A assemble and exert effects upon chromatin structure and gene expression.
      Title: BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression.
    10. Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).
    Submit: New GeneRIF Correction See all (19)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.

    Common 5p15.33 and 6p21.33 variants influence lung cancer risk.

    Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_542434.1 IER3    BIND  PubMed An unspecified isoform of IEX-1 interacts with BAT3. 
    P46379 O15145 ARPC3    HPRD  PubMed  
    P46379 P54259 ATN1    HPRD  PubMed  
    P46379 Q99700 ATXN2    HPRD  PubMed  
    P46379 P61769 B2M    HPRD  PubMed  
    P46379 Q969H8 C19orf10    HPRD  PubMed  
    P46379 Q00536 CDK16    HPRD  PubMed  
    P46379 P11802 CDK4    HPRD  PubMed  
    P46379 P52757 CHN2    HPRD  PubMed  
    P46379 P33240 CSTF2    HPRD  PubMed  
    P46379 P07858 CTSB    HPRD  PubMed  
    P46379 P14091 CTSE    HPRD  PubMed  
    P46379 Q9UBS4 DNAJB11    HPRD  PubMed  
    P46379 Q07507 DPT    HPRD  PubMed  
    P46379 P05305 EDN1    HPRD  PubMed  
    P46379 O95967 EFEMP2    HPRD  PubMed  
    P46379 Q09472 EP300    HPRD  PubMed  
    P46379 Q9BQD7 FAM173A    HPRD  PubMed  
    P46379 Q96IP4 FAM46A    HPRD  PubMed  
    P46379 P26885 FKBP2    HPRD  PubMed  
    P46379 P23416 GLRA2    HPRD  PubMed  
    P46379 P11142 HSPA8    HPRD  PubMed  
    P46379 P24593 IGFBP5    HPRD  PubMed  
    P46379 O95163 IKBKAP    HPRD  PubMed  
    P46379 Q16891 IMMT    HPRD  PubMed  
    P46379 IQ motif containing G IQCG    HPRD  PubMed  
    P46379 Q53G59 KLHL12    HPRD  PubMed  
    P46379 Plasticity related gene 2 LPPR3    HPRD  PubMed  
    P46379 P41271 NBL1    HPRD  PubMed  
    P46379 P56556 NDUFA6    HPRD  PubMed  
    P46379 P69849 NOMO3    HPRD  PubMed  
    P46379 Q8IZL8 PELP1    HPRD  PubMed  
    P46379 O43688 PPAP2C    HPRD  PubMed  
    P46379 P04156 PRNP    HPRD  PubMed  
    P46379 O75400 PRPF40A    HPRD  PubMed  
    P46379 P01270 PTH    HPRD  PubMed  
    P46379 Q05209 PTPN12    HPRD  PubMed  
    P46379 P61006 RAB8A    HPRD  PubMed  
    P46379 Q14257 RCN2    HPRD  PubMed  
    P46379 P48304 REG1B    HPRD  PubMed  
    P46379 Q9BV68 RNF126    HPRD  PubMed  
    P46379 P26447 S100A4    HPRD  PubMed  
    P46379 Q15047 SETDB1    HPRD  PubMed  
    P46379 O43765 SGTA    HPRD  PubMed  
    P46379 Q16637 SMN2    HPRD  PubMed  
    P46379 Q13190 STX5    HPRD  PubMed  
    P46379 P20366 TAC1    HPRD  PubMed  
    P46379 P13385 TDGF1    HPRD  PubMed  
    P46379 Q15388 TOMM20    HPRD  PubMed  
    P46379 Q96S82 UBL7    HPRD  PubMed  
    P46379 Q9NRR5 UBQLN4    HPRD  PubMed  
    P46379 Q8IZH2 XRN1    HPRD  PubMed  
    P46379 O95405 ZFYVE9    HPRD  PubMed  
    BioGRID:113647 BioGRID:106807 ANXA7    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:115401 ARPC3    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:107044 B2M    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:121028 C19orf10    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:107454 CDK4    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:107455 CDK5    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:107460 CDKN1A    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:107548 CHN2    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:107843 CSNK2B    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:107860 CSTF2    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:126653 CTCFL    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113647 BioGRID:107888 CTSB    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:107890 CTSE    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:107894 CTSL1    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:119699 DNAJB11    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:108139 DPT    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:108228 EDN1    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:119026 EFEMP2    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113647 BioGRID:122439 FAM173A    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:108576 FKBP2    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:113918 FZD4    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:108014 GADD45A    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:109187 GSK3B    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:109218 GTF2F2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113647 BioGRID:109535 HSPA1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113647 BioGRID:109702 IGF2    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:109709 IGFBP5    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:114090 IKBKAP    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:116185 IMMT    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:119325 INSIG2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113647 BioGRID:123957 IQCG    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:121890 KLHL12    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:123019 LPPR3    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:114879 MAGED1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113647 BioGRID:111583 MAPK6    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:121570 MAVS    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:113647 BioGRID:110390 MEST    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:110761 NBL1    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:110780 NDUFA6    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:120026 NDUFB11    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:116991 NOMO1    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:113222 NR1H2    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:111136 PCK1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113647 BioGRID:117973 PELP1    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:111317 PIN1    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:111337 PLA2G2A    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:111362 PLK1    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:114170 PPAP2C    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:111523 PPP4C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113647 BioGRID:111606 PRNP    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:111713 PTH    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:110382 RAB8A    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:111817 RAC1    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:107529 RCC1    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:111888 RCN2    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:111900 REG1B    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:117487 RPAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113647 BioGRID:112183 S100A4    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:116152 SEC61B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113647 BioGRID:118079 SERP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113647 BioGRID:107318 SERPINH1    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:115202 SETDB1    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:112490 SMN1    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:111543 SRGN    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:112680 STX5    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:112727 TAC1    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:112856 TDGF1    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:112938 TK1    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:115144 TOMM20    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:114374 TSC22D1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113647 BioGRID:113127 TTR    BioGRID  PubMed Two-hybrid 
    BioGRID:113647 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:113647 BioGRID:113885 UBL4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113647 BioGRID:119068 WRAP73    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113647 BioGRID:119970 XRN1    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    polyubiquitin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    proteasome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ribosome binding IDA
    Inferred from Direct Assay
    more info
    		  
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    apoptosis in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    embryo development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    internal peptidyl-lysine acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    kidney development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    lung development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    synaptonemal complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    tail-anchored membrane protein insertion into ER membrane IDA
    Inferred from Direct Assay
    more info
    		  
    transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    BAT3 complex IDA
    Inferred from Direct Assay
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    large proline-rich protein BAG6
    Names
    large proline-rich protein BAG6
    scythe
    protein G3
    protein Scythe
    HLA-B associated transcript 3
    HLA-B associated transcript-3
    HLA-B-associated transcript 3
    large proline-rich protein BAT3
    BAG family molecular chaperone regulator 6
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098534.1 → NP_001092004.1  large proline-rich protein BAG6 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and utilizes an alternative in-frame splice site in the 5' coding region, compared to variant 1. Variants 2, 3, and 4 encode the same isoform (b), which is 6 aa shorter than isoform a.
      Source sequence(s)
      BC003133, BF515863, BX647244, CX758454, DB492350
      Consensus CDS
      CCDS4709.1
      UniProtKB/Swiss-Prot
      P46379
      Related
      ENSP00000365143, OTTHUMP00000029237, ENST00000375976, OTTHUMT00000076319
      Conserved Domains (3) summary
      pfam12057
      Location:286 – 373
      Blast Score: 343
      DUF3538; Domain of unknown function (DUF3538)
      cd01809
      Location:17 – 87
      Blast Score: 303
      Scythe_N; Ubiquitin-like domain of Scythe protein
      smart00213
      Location:17 – 87
      Blast Score: 213
      UBQ; Ubiquitin homologues

    2. NM_001199697.1 → NP_001186626.1  large proline-rich protein BAG6 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks three alternate in-frame segments compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AK302695, AK304879, AU134255, BU628873
      Consensus CDS
      CCDS56414.1
      UniProtKB/TrEMBL
      B4DZ12
      UniProtKB/TrEMBL
      B4E3V4
      UniProtKB/TrEMBL
      E7EMZ4
      Related
      ENSP00000402856, ENST00000439687
      Conserved Domains (3) summary
      pfam12057
      Location:286 – 373
      Blast Score: 346
      DUF3538; Domain of unknown function (DUF3538)
      cd01809
      Location:17 – 87
      Blast Score: 301
      Scythe_N; Ubiquitin-like domain of Scythe protein
      smart00213
      Location:17 – 87
      Blast Score: 212
      UBQ; Ubiquitin homologues

    3. NM_001199698.1 → NP_001186627.1  large proline-rich protein BAG6 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AK302695, AK304879, AU134255, BC003133, BU628873
      Consensus CDS
      CCDS56415.1
      UniProtKB/TrEMBL
      B4DZ12
      UniProtKB/TrEMBL
      B4E3V4
      UniProtKB/TrEMBL
      F8VXY4
      UniProtKB/Swiss-Prot
      P46379
      Related
      ENSP00000354875, ENST00000362049
      Conserved Domains (3) summary
      pfam12057
      Location:286 – 373
      Blast Score: 345
      DUF3538; Domain of unknown function (DUF3538)
      cd01809
      Location:17 – 87
      Blast Score: 303
      Scythe_N; Ubiquitin-like domain of Scythe protein
      smart00213
      Location:17 – 87
      Blast Score: 213
      UBQ; Ubiquitin homologues

    4. NM_004639.3 → NP_004630.3  large proline-rich protein BAG6 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      BC003133, BF515863, BX384328, M33519
      Consensus CDS
      CCDS47403.1
      UniProtKB/Swiss-Prot
      P46379
      Related
      ENSP00000365131, OTTHUMP00000029238, ENST00000375964, OTTHUMT00000076321
      Conserved Domains (3) summary
      pfam12057
      Location:292 – 379
      Blast Score: 343
      DUF3538; Domain of unknown function (DUF3538)
      cd01809
      Location:17 – 87
      Blast Score: 303
      Scythe_N; Ubiquitin-like domain of Scythe protein
      smart00213
      Location:17 – 87
      Blast Score: 212
      UBQ; Ubiquitin homologues

    5. NM_080702.2 → NP_542433.1  large proline-rich protein BAG6 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and utilizes an alternative in-frame splice site in the 5' coding region, compared to variant 1. Variants 2, 3, and 4 encode the same isoform (b), which is 6 aa shorter than isoform a.
      Source sequence(s)
      BC003133, BF515863, BX384328, DB454794
      Consensus CDS
      CCDS4709.1
      UniProtKB/Swiss-Prot
      P46379
      Related
      ENSP00000211379, OTTHUMP00000029239, ENST00000211379, OTTHUMT00000076322
      Conserved Domains (3) summary
      pfam12057
      Location:286 – 373
      Blast Score: 343
      DUF3538; Domain of unknown function (DUF3538)
      cd01809
      Location:17 – 87
      Blast Score: 303
      Scythe_N; Ubiquitin-like domain of Scythe protein
      smart00213
      Location:17 – 87
      Blast Score: 213
      UBQ; Ubiquitin homologues

    6. NM_080703.2 → NP_542434.1  large proline-rich protein BAG6 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) utilizes an alternative in-frame splice site in the 5' coding region, compared to variant 1. Variants 2, 3, and 4 encode the same isoform (b), which is 6 aa shorter than isoform a.
      Source sequence(s)
      BC003133, BF515863, BX384328, DB459208
      Consensus CDS
      CCDS4709.1
      UniProtKB/Swiss-Prot
      P46379
      Conserved Domains (3) summary
      pfam12057
      Location:286 – 373
      Blast Score: 343
      DUF3538; Domain of unknown function (DUF3538)
      cd01809
      Location:17 – 87
      Blast Score: 303
      Scythe_N; Ubiquitin-like domain of Scythe protein
      smart00213
      Location:17 – 87
      Blast Score: 213
      UBQ; Ubiquitin homologues

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      31606805..31620477, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.2 Reference GRCh37.p5 ALT_REF_LOCI_2

      Range
      3116416..3130096, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.1 Reference GRCh37.p5 ALT_REF_LOCI_3

      Range
      2892376..2906056, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.1 Reference GRCh37.p5 ALT_REF_LOCI_4

      Range
      2949688..2963366, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.1 Reference GRCh37.p5 ALT_REF_LOCI_5

      Range
      2986492..3000157, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.1 Reference GRCh37.p5 ALT_REF_LOCI_6

      Range
      2900437..2914115, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.1 Reference GRCh37.p5 ALT_REF_LOCI_7

      Range
      2937602..2951276, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      31392973..31406702, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF129756.1 AAD18085.1
    genomic AL662801.7 (111697..125369) None
    genomic AL662847.6 (125458..135782) None
    genomic AL670886.6 (1999..5354) None
    genomic AL805934.3 CAI18501.1
      CAI18503.2
      CAI18504.1
      CAI18505.2
      CAI18506.2
      CAI18508.2
      CAI18509.1
      CAO03653.1
      CAO03654.1
      CAO03655.1
      CAO03656.1
      CAO03657.1
      CAO03658.1
      CAO03659.1
      CAO03660.1
      CAO03661.1
      CAO03662.1
      CAO03663.1
      CAO03664.1
      CAO03665.1
    genomic AL805934.3 CAI18501.1
      CAI18503.2
      CAI18504.1
      CAI18505.2
      CAI18506.2
      CAI18508.2
      CAI18509.1
      CAO03653.1
      CAO03654.1
      CAO03655.1
      CAO03656.1
      CAO03657.1
      CAO03658.1
      CAO03659.1
      CAO03660.1
      CAO03661.1
      CAO03662.1
      CAO03663.1
      CAO03664.1
      CAO03665.1
    genomic BA000025.2 BAB63390.1
    genomic BX511262.7 CAM45799.1
      CAM45800.1
    genomic CH471081.1 EAX03453.1
      EAX03454.1
      EAX03455.1
      EAX03456.1
      EAX03457.1
      EAX03458.1
      EAX03459.1
      EAX03460.1
    genomic CR354443.4 CAQ06971.1
      CAQ06972.1
      CAQ06973.1
      CAQ06974.1
      CAQ06975.1
      CAQ06976.1
      CAQ06977.1
      CAQ06978.1
      CAQ06979.1
      CAQ06980.1
      CAQ06981.1
      CAQ06982.1
      CAQ06983.1
      CAQ06984.1
      CAQ06985.1
      CAQ06986.1
      CAQ06987.1
      CAQ06988.1
      CAQ06989.1
      CAQ06990.1
    genomic CR354443.4 CAQ06971.1
      CAQ06972.1
      CAQ06973.1
      CAQ06974.1
      CAQ06975.1
      CAQ06976.1
      CAQ06977.1
      CAQ06978.1
      CAQ06979.1
      CAQ06980.1
      CAQ06981.1
      CAQ06982.1
      CAQ06983.1
      CAQ06984.1
      CAQ06985.1
      CAQ06986.1
      CAQ06987.1
      CAQ06988.1
      CAQ06989.1
      CAQ06990.1
    genomic CR753842.3 CAQ06543.1
      CAQ06544.1
    genomic CR753842.3 CAQ06543.1
      CAQ06544.1
    genomic CR753892.5 CAQ06922.1
    genomic CR759761.9 (27492..41157) None
    genomic M33520.1 AAA35588.1
    genomic M33521.1 AAA35588.1
    mRNA AK302695.1 BAG63924.1
    mRNA AK304879.1 BAG65616.1
    mRNA AU134255.1 None
    mRNA BC003133.1 AAH03133.1
    mRNA BF515863.1 None
    mRNA BU628873.1 None
    mRNA BX384328.2 None
    mRNA BX647244.1 CAI46045.1
    mRNA CX758454.1 None
    mRNA DB454794.1 None
    mRNA DB459208.1 None
    mRNA DB492350.1 None
    mRNA M33519.1 AAA35587.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46379.2 GenPept UniProtKB/Swiss-Prot:P46379
    Q5SQ39 GenPept UniProtKB/TrEMBL:Q5SQ39
    Q5SQ40 GenPept UniProtKB/TrEMBL:Q5SQ40
    Q5SQ42 GenPept UniProtKB/TrEMBL:Q5SQ42
    Help top of page

    Additional Links

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