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DEK DEK proto-oncogene [ Homo sapiens (human) ]

Gene ID: 7913, updated on 26-May-2016
Official Symbol
DEKprovided by HGNC
Official Full Name
DEK proto-oncogeneprovided by HGNC
Primary source
HGNC:HGNC:2768
See related
Ensembl:ENSG00000124795 HPRD:00503; MIM:125264; Vega:OTTHUMG00000014319
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D6S231E
Summary
This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Orthologs
Location:
6p22.3
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (18224169..18264568, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (18224400..18264799, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene thiopurine S-methyltransferase Neighboring gene lysine demethylase 1B Neighboring gene ring finger protein 144B Neighboring gene IMP (inosine monophosphate) dehydrogenase 1 pseudogene 9 Neighboring gene DEAD-box helicase 18 pseudogene 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • B-WICH complex positively regulates rRNA expression, organism-specific biosystem (from REACTOME)
    B-WICH complex positively regulates rRNA expression, organism-specific biosystemThe B-WICH complex is a large 3 Mdalton complex containing SMARCA5 (SNF2H), BAZ1B (WSTF), ERCC6 (CSB), MYO1C (Nuclear myosin 1c) (Cavellan et al. 2006, Percipalle et al. 2006, Vintermist et al. 2001,...
  • Epigenetic regulation of gene expression, organism-specific biosystem (from REACTOME)
    Epigenetic regulation of gene expression, organism-specific biosystemEpigenetic processes regulate gene expression by modulating the frequency, rate, or extent of gene expression in a mitotically or meiotically heritable way that does not entail a change in the DNA se...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Positive epigenetic regulation of rRNA expression, organism-specific biosystem (from REACTOME)
    Positive epigenetic regulation of rRNA expression, organism-specific biosystemTranscription of rRNA genes is controlled by epigenetic activation and repression (reviewed in Percipalle and Farrants 2006, McStay and Grummt 2008, Goodfellow and Zomerdijk 2012, Grummt and Langst 2...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
contractile fiber IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
protein DEK
Names
DEK oncogene (DNA binding)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042290.1 RefSeqGene

    Range
    5001..45400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001134709.1NP_001128181.1  protein DEK isoform 2

    See identical proteins and their annotated locations for NP_001128181.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK297749, AU131262, BC035259, BQ574048
    Consensus CDS
    CCDS47382.1
    UniProtKB/Swiss-Prot
    P35659
    Related
    ENSP00000244776, OTTHUMP00000221544, ENST00000244776, OTTHUMT00000367860
    Conserved Domains (2) summary
    smart00513
    Location:115149
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam08766
    Location:287341
    DEK_C; DEK C terminal domain
  2. NM_003472.3NP_003463.1  protein DEK isoform 1

    See identical proteins and their annotated locations for NP_003463.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AU131262, BC035259, CN388433
    Consensus CDS
    CCDS34344.1
    UniProtKB/Swiss-Prot
    P35659
    Related
    ENSP00000380414, OTTHUMP00000016078, ENST00000397239, OTTHUMT00000039962
    Conserved Domains (2) summary
    smart00513
    Location:149183
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam08766
    Location:321375
    DEK_C; DEK C terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    18224169..18264568 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514889.1XP_011513191.1  

    Conserved Domains (1) summary
    smart00513
    Location:149183
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

RNA

  1. XR_926307.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    18226996..18267392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)