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    USP7 ubiquitin specific peptidase 7 (herpes virus-associated) [ Homo sapiens (human) ]

    Gene ID: 7874, updated on 18-May-2013
    Official Symbol
    USP7provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 7 (herpes virus-associated)provided by HGNC
    Primary source
    HGNC:12630
    See related
    Ensembl:ENSG00000187555; HPRD:03950; MIM:602519; Vega:OTTHUMG00000176903
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TEF1; HAUSP
    Location :
    16p13.3
    Sequence :
    Chromosome: 16; NC_000016.9 (8985951..9057341, complement)
    See USP7 in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene phosphomannomutase 2 Neighboring gene calcium regulated heat stable protein 1, 24kDa Neighboring gene chromosome 16 open reading frame 72 Neighboring gene ribosomal protein L21 pseudogene 119

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description
    NP_003461.1 NP_039875.1 HHV4gp098    BIND  PubMed EBNA1 interacts with USP7. This interaction was modeled on a demonstrated interaction between EBNA1 from an unspecified strain of Epstein-Barr virus and human USP7. 
    NP_003461.1 NP_002383.1 MDM2    BIND  PubMed Mdm2 interacts with HAUSP. This interaction was modeled on a demonstrated interaction between Mdm2 from an unspecified species and human HAUSP. 
    NP_003461.1 NP_002384.1 MDM4    BIND  PubMed Hdmx interacts with HAUSP. 
    NP_003461.1 NP_000537.2 TP53    BIND  PubMed p53 interacts with HAUSP. 
    Q93009 Q96AP0 ACD    HPRD  PubMed  
    Q93009 Q9HBZ2 ARNT2    HPRD  PubMed  
    Q93009 P54253 ATXN1    HPRD  PubMed  
    Q93009 Q6W2J9 BCOR    HPRD  PubMed  
    Q93009 Chromosome 1 open reading frame 165 BEND5    HPRD  PubMed  
    Q93009 cAMP responsive element binding protein 3 like 3 CREB3L3    HPRD  PubMed  
    Q93009 Q9UER7 DAXX    HPRD  PubMed  
    Q93009 Q96EY1 DNAJA3    HPRD  PubMed  
    Q93009 Q01844 EWSR1    HPRD  PubMed  
    Q93009 Q76N89 HECW1    HPRD  PubMed  
    Q93009 Q15011 HERPUD1    HPRD  PubMed  
    Q93009 O43464 HTRA2    HPRD  PubMed  
    Q93009 Q9P2G9 KLHL8    HPRD  PubMed  
    Q93009 Q9HCI5 MAGEE1    HPRD  PubMed  
    Q93009 Q9H992 MARCH7    HPRD  PubMed  
    Q93009 Q00987 MDM2    HPRD  PubMed  
    Q93009 O15151 MDM4    HPRD  PubMed  
    Q93009 EF hand calcium binding protein 2 NECAB2    HPRD  PubMed  
    Q93009 Q9GZU2 PEG3    HPRD  PubMed  
    Q93009 Q9NRD5 PICK1    HPRD  PubMed  
    Q93009 Casein kinase II interacting protein 1 PLEKHO1    HPRD  PubMed  
    Q93009 O60437 PPL    HPRD  PubMed  
    Q93009 Hypothetical protein FLJ10324 RADIL    HPRD  PubMed  
    Q93009 Q5VTB9 RNF220    HPRD  PubMed  
    Q93009 Q86TM6 SYVN1    HPRD  PubMed  
    Q93009 Q92844 TANK    HPRD  PubMed  
    Q93009 Q99426 TBCB    HPRD  PubMed  
    Q93009 P42166 TMPO    HPRD  PubMed  
    Q93009 P04637 TP53    HPRD  PubMed  
    Q93009 Q13077 TRAF1    HPRD  PubMed  
    Q93009 Q12933 TRAF2    HPRD  PubMed  
    Q93009 Q13114 TRAF3    HPRD  PubMed  
    Q93009 Q9BUZ4 TRAF4    HPRD  PubMed  
    Q93009 O00463 TRAF5    HPRD  PubMed  
    Q93009 Q9Y4K3 TRAF6    HPRD  PubMed  
    Q93009 Q8IYM9 TRIM22    HPRD  PubMed  
    Q93009 Q12816 TRO    HPRD  PubMed  
    Q93009 Q93009 USP7    HPRD  PubMed  
    Q93009 O00308 WWP2    HPRD  PubMed  
    Q93009 Q9ULU4 ZMYND8    HPRD  PubMed  
    Q93009 OAZ ZNF423    HPRD  PubMed  
    BioGRID:113622 BioGRID:122379 ACD    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:113818 AKAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:115244 ARNT2    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:123745 ATG10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:112217 ATXN1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113622 BioGRID:118855 BABAM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:120228 BCOR    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:122782 BEND5    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:107116 BMI1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113622 BioGRID:122599 BRCC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:114946 BRE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:114621 BUB3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:121487 CBX8    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113622 BioGRID:113725 CCDC6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:116312 CDC37    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:107452 CDK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:107536 CHEK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113622 BioGRID:120861 CHFR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113622 BioGRID:122015 CLSPN    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113622 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:116176 COPS6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:124213 CREB3L3    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:107789 CRKL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:114030 CUL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:114029 CUL4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:114028 CUL4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:107985 DAXX    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:113622 BioGRID:117545 DCAF4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:114547 DNAJA3    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:108123 DNMT1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113622 BioGRID:108125 DNMT3A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113622 BioGRID:124527 DOCK7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:971751 EBNA-1    BioGRID  PubMed Affinity Capture-MS; Co-crystal Structure; Co-purification; Protein-peptide; Reconstituted Complex 
    BioGRID:113622 BioGRID:114265 EED    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113622 BioGRID:108291 EIF4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:108386 ERCC6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:108431 EWSR1    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:108446 EZH2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113622 BioGRID:116784 FAM175B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:123513 FBXO38    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:108579 FKBP5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:109576 FOXN2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113622 BioGRID:108598 FOXO3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113622 BioGRID:110449 FOXO4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113622 BioGRID:114360 GMPS    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:113622 BioGRID:109224 GTF2I    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:116705 HECW1    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:115060 HERPUD1    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:1777030 HHV8GK18_gp81    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113622 BioGRID:126106 HIST3H2BB    BioGRID  PubMed Biochemical Activity 
    BioGRID:113622 BioGRID:112480 HLTF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:109428 HNRNPH1    BioGRID  PubMed Co-fractionation 
    BioGRID:113622 BioGRID:118165 HTRA2    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:115385 HUWE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:114089 IKBKG    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113622 BioGRID:115779 KAT5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113622 BioGRID:115114 KIAA0101    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:116300 KIF3A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:116652 KLHDC10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:121618 KLHL8    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:110287 MAGEB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:116121 MAGED2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:121718 MAGEE1    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:120036 MAGEL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:110292 MAL    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:122319 MARCH7    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:121760 MARK4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:110341 MCM4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:110342 MCM5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:110343 MCM6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:122976 MCMBP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Co-fractionation; Protein-peptide; Reconstituted Complex 
    BioGRID:113622 BioGRID:110359 MDM4    BioGRID  PubMed Co-crystal Structure; Protein-peptide; Reconstituted Complex 
    BioGRID:113622 BioGRID:119471 MEX3C    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113622 BioGRID:122103 MMS19    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:110700 MYD88    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113622 BioGRID:120035 NECAB2    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:110913 NOTCH1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113622 BioGRID:113222 NR1H2    BioGRID  PubMed Co-fractionation 
    BioGRID:113622 BioGRID:110982 NUP98    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:116239 OGFR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:124243 PCGF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:113497 PCGF2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113622 BioGRID:115618 PCGF3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:115332 PDCD6IP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113622 BioGRID:111204 PEG3    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:124661 PHLDB2    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:114849 PICK1    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:122109 PJA1    BioGRID  PubMed Biochemical Activity 
    BioGRID:113622 BioGRID:111337 PLA2G2A    BioGRID  PubMed Biochemical Activity 
    BioGRID:113622 BioGRID:119355 PLEKHO1    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:111384 PML    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:113622 BioGRID:124467 PPIL4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:111488 PPL    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:111491 PPM1G    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:111529 PPP6C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:120579 PPP6R3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:121549 PRR12    BioGRID  PubMed Co-fractionation 
    BioGRID:113622 BioGRID:111656 PSMA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:111657 PSMA3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113622 BioGRID:111659 PSMA5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113622 BioGRID:111665 PSMB4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113622 BioGRID:111666 PSMB5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113622 BioGRID:111667 PSMB6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113622 BioGRID:111669 PSMB8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113622 BioGRID:120823 RADIL    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:114054 RAE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:111849 RARA    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113622 BioGRID:115862 RBCK1    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:111902 RELA    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113622 BioGRID:125593 RFFL    BioGRID  PubMed Biochemical Activity 
    BioGRID:113622 BioGRID:111947 RING1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113622 BioGRID:971427 RL2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113622 BioGRID:971426 RL2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113622 BioGRID:111972 RNF2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113622 BioGRID:120481 RNF220    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:113622 BioGRID:116125 RNPS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:116067 RUVBL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:116997 RYBP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:115661 SCML2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:119289 SH3GLB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:119602 SIRT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:113622 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:112608 SRP68    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:113188 SUMO1    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:117059 SUZ12    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113622 BioGRID:124085 SYVN1    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:107575 TBCB    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113622 BioGRID:114745 TCEAL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:122998 TCEAL4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:122595 THTPA    BioGRID  PubMed Co-fractionation 
    BioGRID:113622 BioGRID:112967 TMPO    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Protein-peptide; Reconstituted Complex 
    BioGRID:113622 BioGRID:113037 TRAF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113622 BioGRID:113038 TRAF2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113622 BioGRID:113039 TRAF3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113622 BioGRID:114979 TRAF4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113622 BioGRID:113040 TRAF5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113622 BioGRID:113041 TRAF6    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113622 BioGRID:115435 TRAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:115628 TRIM22    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:111919 TRIM27    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:116257 TRIM31    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:121415 TRIM54    BioGRID  PubMed Biochemical Activity 
    BioGRID:113622 BioGRID:124194 TRIM55    BioGRID  PubMed Biochemical Activity 
    BioGRID:113622 BioGRID:124195 TRIM63    BioGRID  PubMed Biochemical Activity 
    BioGRID:113622 BioGRID:123541 TRIM8    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:114731 TRIP12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:113067 TRO    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:124538 TSPYL5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113622 BioGRID:114755 TXNL1    BioGRID  PubMed Co-fractionation 
    BioGRID:113622 BioGRID:115691 UBAC1    BioGRID  PubMed Co-fractionation 
    BioGRID:113622 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity; Protein-peptide; Reconstituted Complex 
    BioGRID:113622 BioGRID:115791 UBD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:118150 UBE2S    BioGRID  PubMed Biochemical Activity 
    BioGRID:113622 BioGRID:118893 UHRF1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113622 BioGRID:125434 UHRF2    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:1677983 UL35    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113622 BioGRID:113232 UQCRFS1    BioGRID  PubMed Co-fractionation 
    BioGRID:113622 BioGRID:113233 UQCRFS1P1    BioGRID  PubMed Co-fractionation 
    BioGRID:113622 BioGRID:113866 USP11    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113622 BioGRID:114551 USP14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:115283 USP15    BioGRID  PubMed Biochemical Activity 
    BioGRID:113622 BioGRID:116078 USP19    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:117950 USP21    BioGRID  PubMed Biochemical Activity 
    BioGRID:113622 BioGRID:121683 USP28    BioGRID  PubMed Biochemical Activity 
    BioGRID:113622 BioGRID:113622 USP7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113622 BioGRID:121689 UVSSA    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113622 BioGRID:261960 Usp7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113622 BioGRID:112711 VAMP2    BioGRID  PubMed Co-fractionation 
    BioGRID:113622 BioGRID:119683 VPS29    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113622 BioGRID:120563 VPS53    BioGRID  PubMed Co-fractionation 
    BioGRID:113622 BioGRID:120092 WDR74    BioGRID  PubMed Co-fractionation 
    BioGRID:113622 BioGRID:116244 WWP2    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:116420 XPOT    BioGRID  PubMed Co-fractionation 
    BioGRID:113622 BioGRID:113352 XRCC4    BioGRID  PubMed Co-fractionation 
    BioGRID:113622 BioGRID:115441 YAF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:121117 YLPM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:120739 ZCCHC8    BioGRID  PubMed Co-fractionation 
    BioGRID:113622 BioGRID:117146 ZMYND8    BioGRID  PubMed Two-hybrid 
    BioGRID:113622 BioGRID:113540 ZNF207    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113622 BioGRID:116718 ZNF423    BioGRID  PubMed Two-hybrid 
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
      FoxO family signaling, organism-specific biosystem
      FoxO family signaling
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
      p53 pathway, organism-specific biosystem
      p53 pathway

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
     
    p53 binding IDA
    Inferred from Direct Assay
    more info
     
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin thiolesterase activity IDA
    Inferred from Direct Assay
    more info
     
    ubiquitin thiolesterase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-specific protease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    maintenance of DNA methylation IMP
    Inferred from Mutant Phenotype
    more info
     
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription-coupled nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
     
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    virus-host interaction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    PML body IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 7
    Names
    ubiquitin carboxyl-terminal hydrolase 7
    ubiquitin thioesterase 7
    deubiquitinating enzyme 7
    ubiquitin-specific-processing protease 7
    herpesvirus-associated ubiquitin-specific protease
    Herpes virus-associated ubiquitin-specific protease
    ubiquitin specific protease 7 (herpes virus-associated)
    NP_003461.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003470.2NP_003461.2  ubiquitin carboxyl-terminal hydrolase 7

      Status: VALIDATED

      Source sequence(s)
      AC022167, AY376241, Z72499
      Consensus CDS
      CCDS32385.1
      UniProtKB/TrEMBL
      Q6U8A4
      UniProtKB/Swiss-Prot
      Q93009
      Related
      ENSP00000343535, OTTHUMP00000255365, ENST00000344836, OTTHUMT00000434268
      Conserved Domains (4) summary
      COG5077
      Location:551100
      Blast Score: 1577
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd03772
      Location:67202
      Blast Score: 636
      MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...
      cd02659
      Location:212523
      Blast Score: 1046
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam12436
      Location:532566
      Blast Score: 132
      USP7; Ubiquitin-specific protease 7

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p10 Primary Assembly

      Range
      8985951..9057341, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      8907081..8945418, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018927.1 Alternate CHM1_1.0

      Range
      8882359..8920611, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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