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USP7 ubiquitin specific peptidase 7 (herpes virus-associated) [ Homo sapiens (human) ]

Gene ID: 7874, updated on 19-Jul-2014
Official Symbol
USP7provided by HGNC
Official Full Name
ubiquitin specific peptidase 7 (herpes virus-associated)provided by HGNC
Primary source
HGNC:12630
See related
Ensembl:ENSG00000187555; HPRD:03950; MIM:602519; Vega:OTTHUMG00000176903
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TEF1; HAUSP
See USP7 in Epigenomics, MapViewer
Location:
16p13.3
Exon count:
33
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 16 NC_000016.10 (8892094..8963484, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (8985951..9057341, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene calcium regulated heat stable protein 1, 24kDa Neighboring gene lipopolysaccharide-induced tumor necrosis factor-alpha factor-like Neighboring gene chromosome 16 open reading frame 72 Neighboring gene ribosomal protein L21 pseudogene 119

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
    Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • Epstein-Barr virus infection, conserved biosystem (from KEGG)
    Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
    FoxO family signaling, organism-specific biosystem
    FoxO family signaling
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • Herpes simplex infection, organism-specific biosystem (from KEGG)
    Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Herpes simplex infection, conserved biosystem (from KEGG)
    Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Viral carcinogenesis, organism-specific biosystem (from KEGG)
    Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral carcinogenesis, conserved biosystem (from KEGG)
    Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
    p53 pathway, organism-specific biosystem
    p53 pathway
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 
p53 binding IDA
Inferred from Direct Assay
more info
 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin thiolesterase activity IDA
Inferred from Direct Assay
more info
 
ubiquitin thiolesterase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-specific protease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
maintenance of DNA methylation IMP
Inferred from Mutant Phenotype
more info
 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription-coupled nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PML body IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
ubiquitin carboxyl-terminal hydrolase 7
Names
ubiquitin carboxyl-terminal hydrolase 7
ubiquitin thioesterase 7
deubiquitinating enzyme 7
ubiquitin-specific-processing protease 7
herpesvirus-associated ubiquitin-specific protease
Herpes virus-associated ubiquitin-specific protease
ubiquitin specific protease 7 (herpes virus-associated)
NP_001273386.1
NP_001273387.1
NP_003461.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286457.1NP_001273386.1  ubiquitin carboxyl-terminal hydrolase 7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC022167, AK316441
    Consensus CDS
    CCDS66941.1
    UniProtKB/TrEMBL
    B7ZAX6
    Conserved Domains (5) summary
    COG5077
    Location:391084
    Blast Score: 1688
    COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02659
    Location:196507
    Blast Score: 1226
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd03772
    Location:51186
    Blast Score: 690
    MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...
    pfam12436
    Location:603849
    Blast Score: 865
    USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7
    pfam14533
    Location:8581072
    Blast Score: 641
    USP7_C2; Ubiquitin-specific protease C-terminal
  2. NM_001286458.1NP_001273387.1  ubiquitin carboxyl-terminal hydrolase 7 isoform 3

    See proteins identical to NP_001273387.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and contains an alternate internal exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC022167, AK302912, AK316441
    UniProtKB/TrEMBL
    B7Z855
    UniProtKB/TrEMBL
    B7ZAX6
    UniProtKB/TrEMBL
    F5H8E5
    Conserved Domains (5) summary
    COG5077
    Location:61001
    Blast Score: 1646
    COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02659
    Location:113424
    Blast Score: 1230
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam12436
    Location:520766
    Blast Score: 861
    USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7
    pfam14533
    Location:775989
    Blast Score: 636
    USP7_C2; Ubiquitin-specific protease C-terminal
    cl02446
    Location:1103
    Blast Score: 517
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
  3. NM_003470.2NP_003461.2  ubiquitin carboxyl-terminal hydrolase 7 isoform 1

    See proteins identical to NP_003461.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC022167, AY376241, Z72499
    Consensus CDS
    CCDS32385.1
    UniProtKB/TrEMBL
    Q6U8A4
    UniProtKB/Swiss-Prot
    Q93009
    Related
    ENSP00000343535, OTTHUMP00000255365, ENST00000344836, OTTHUMT00000434268
    Conserved Domains (5) summary
    COG5077
    Location:551100
    Blast Score: 1691
    COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02659
    Location:212523
    Blast Score: 1235
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd03772
    Location:67202
    Blast Score: 688
    MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...
    pfam12436
    Location:619865
    Blast Score: 863
    USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7
    pfam14533
    Location:8741088
    Blast Score: 639
    USP7_C2; Ubiquitin-specific protease C-terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000016.10 

    Range
    8892094..8963484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000148.1 

    Range
    8907081..8951744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 

    Range
    8985936..9057340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)