My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    LAPTM5 lysosomal protein transmembrane 5 [ Homo sapiens ]

    Gene ID: 7805, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    LAPTM5provided by HGNC
    Official Full Name
    lysosomal protein transmembrane 5provided by HGNC
    Primary source
    HGNC:29612
    Locus tag
    RP5-1166H10.3
    See related
    Ensembl:ENSG00000162511; HPRD:03280; MIM:601476; Vega:OTTHUMG00000003707
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLAST6; FLJ61683; FLJ97251; MGC125860; MGC125861
    Summary
    This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. [provided by RefSeq, Feb 2009]
    Help top of page

    Genomic context

    Location :
    1p34
    Sequence :
    Chromosome: 1; NC_000001.10 (31205315..31230683, complement)
    See LAPTM5 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, U Neighboring gene uncharacterized LOC100129196 Neighboring gene microRNA 4420 Neighboring gene matrilin 1, cartilage matrix protein Neighboring gene small nucleolar RNA, C/D box 103A Neighboring gene syndecan 3 Neighboring gene pumilio homolog 1 (Drosophila)

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. HECT-type ubiquitin ligase ITCH targets lysosomal-associated protein multispanning transmembrane 5 (LAPTM5) and prevents LAPTM5-mediated cell death. Ishihara T, et al. J Biol Chem, 2011 Dec 23. PMID 22009753.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Persaud A, et al. Mol Syst Biol, 2009. PMID 19953087.
    5. Lysosomal-associated protein multispanning transmembrane 5 gene (LAPTM5) is associated with spontaneous regression of neuroblastomas. Inoue J, et al. PLoS One, 2009 Sep 29. PMID 19787053.

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. LAPTM5 is a substrate of the ITCH-mediated degradation and its protein level is negatively regulated by ITCH
      Title: HECT-type ubiquitin ligase ITCH targets lysosomal-associated protein multispanning transmembrane 5 (LAPTM5) and prevents LAPTM5-mediated cell death.
    2. LAPTM5-mediated programmed cell death is closely associated with the spontaneous regression of neuroblastomas
      Title: Lysosomal-associated protein multispanning transmembrane 5 gene (LAPTM5) is associated with spontaneous regression of neuroblastomas.
    3. results suggest that loss of E3 gene expression might be a crucial event during the progression of human MM
      Title: Inactivation of the E3/LAPTm5 gene by chromosomal rearrangement and DNA methylation in human multiple myeloma.
    4. LAPTM5 shows stage-specific expression during B cell differentiation. It may be involved in B cell malignancies.
      Title: Stage-specific expression of Clast6/E3/LAPTM5 during B cell differentiation: elevated expression in human B lymphomas.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q13571 Q8IZ07 ANKRD13A    HPRD  PubMed  
    Q13571 Q96GG9 DCUN1D1    HPRD  PubMed  
    Q13571 Q9Y6I3 EPN1    HPRD  PubMed  
    Q13571 O95208 EPN2    HPRD  PubMed  
    Q13571 Q9H201 EPN3    HPRD  PubMed  
    Q13571 P42566 EPS15    HPRD  PubMed  
    Q13571 Hect domain and RCC1 like domain 1 HERC1    HPRD  PubMed  
    Q13571 Q9Y5J3 HEY1    HPRD  PubMed  
    Q13571 Hairy/enhancer-of-split related with YRPW motif-like HEYL    HPRD  PubMed  
    Q13571 Q7Z6Z7 HUWE1    HPRD  PubMed  
    Q13571 P08729 KRT7    HPRD  PubMed  
    Q13571 Q96PU5 NEDD4L    HPRD  PubMed  
    Q13571 Q8IYW5 RNF168    HPRD  PubMed  
    Q13571 Q9HAU4 SMURF2    HPRD  PubMed  
    Q13571 P21580 TNFAIP3    HPRD  PubMed  
    Q13571 Q6ZVM7 TOM1L2    HPRD  PubMed  
    Q13571 P62987 UBA52    HPRD  PubMed  
    Q13571 Q9BSL1 UBAC1    HPRD  PubMed  
    Q13571 Q92995 USP13    HPRD  PubMed  
    Q13571 Q9H0M0 WWP1    HPRD  PubMed  
    BioGRID:113580 BioGRID:116775 GGA3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113580 BioGRID:123747 ITCH    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113580 BioGRID:110811 NEDD4    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113580 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Lysosome, organism-specific biosystem (from KEGG)
      Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
    • Lysosome, conserved biosystem (from KEGG)
      Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    integral to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    lysosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    lysosomal-associated transmembrane protein 5
    Names
    lysosomal-associated transmembrane protein 5
    retinoic acid-inducible E3 protein
    human retinoic acid-inducible E3 protein
    CD40-ligand-activated specific transcripts
    lysosomal multispanning membrane protein 5
    lysosomal-associated multitransmembrane protein 5
    lysosomal associated multispanning membrane protein 5
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006762.2 → NP_006753.1  lysosomal-associated transmembrane protein 5

      Status: REVIEWED

      Source sequence(s)
      AL137857, BC106897, BF000809, CT003824, D42042
      Consensus CDS
      CCDS337.1
      UniProtKB/Swiss-Prot
      Q13571
      UniProtKB/TrEMBL
      Q5TBB8
      Related
      ENSP00000294507, OTTHUMP00000003806, ENST00000294507, OTTHUMT00000010463
      Conserved Domains (1) summary
      cl04276
      Location:4 – 262
      Blast Score: 946
      Mtp; Golgi 4-transmembrane spanning transporter

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      31205315..31230683, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      29311671..29337045, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL137027.17 CAI19267.1
    genomic AL137857.29 CAI19321.1
    genomic CH471059.2 EAX07640.1
      EAX07641.1
    genomic U30499.1 None
    mRNA AF401210.1 None
    mRNA AK292009.1 BAF84698.1
    mRNA AK297014.1 BAG59547.1
    mRNA BC106896.1 AAI06897.1
    mRNA BC106897.1 AAI06898.1
    mRNA BF000809.1 None
    mRNA CT003824.1 None
    mRNA D42042.1 BAA07643.1
    mRNA U30498.1 AAA74018.1
    mRNA U51240.1 AAB08975.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13571.1 GenPept UniProtKB/Swiss-Prot:Q13571
    Q5TBB8 GenPept UniProtKB/TrEMBL:Q5TBB8
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...