ZNF217 zinc finger protein 217 [Homo sapiens] - Gene

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Summary

Official Symbol: ZNF217provided by HGNC
Official Full Name: zinc finger protein 217provided by HGNC
Primary source: HGNC:13009
Locus tag: RP4-724E16.3
See related: Ensembl:ENSG00000171940; HPRD:04272; MIM:602967; Vega:OTTHUMG00000032764
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZABC1

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Genomic context

Location :: 20q13.2

Sequence :: Chromosome: 20; NC_000020.10 (52183610..52199636, complement)

See ZNF217 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

multi-zinc finger protein ZNF217 contacts DNA through a two-finger domain
Title: The multi-zinc finger protein ZNF217 contacts DNA through a two-finger domain.
ZNF217 is overexpressed in GBMs and contributes to the maintenance of GSCs, which is regulated by HIFs released by the hypoxic environment of the tumor
Title: Overexpression of ZNF217 in glioblastoma contributes to the maintenance of glioma stem cells regulated by hypoxia-inducible factors.
Data suggest that ZNF217 might play an important role in breast neoplastic progression and chemoresistance, and that Aurora-A might be involved in ZNF217-mediated effects.
Title: ZNF217 confers resistance to the pro-apoptotic signals of paclitaxel and aberrant expression of Aurora-A in breast cancer cells.
results show that ZNF217 regulates ErbB3 expression
Title: ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells.
ZNF217 amplification was associated with medullary breast cancer.
Title: CCND1 and ZNF217 gene amplification is equally frequent in BRCA1 and BRCA2 associated and non-BRCA breast cancer.
ZNF217 can be an important candidate gene responsible for the occurrence and progression of ovarian carcinomas.
Title: [Expression of ZNF217 in human ovarian cystadenocarcinoma and its clinical significance].
ZNF217 assembles a distinct set of histone modifying proteins at target DNA sites that act synergistically in transcriptional repression.
Title: The ZNF217 oncogene is a candidate organizer of repressive histone modifiers.
These results establish the ZNF217 complex as a novel negative regulator of the p15(ink4b) gene and may constitute an important link between amplification of ZNF217 and the loss of TGF-beta responsiveness in breast cancer.
Title: Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex.
Suggest that ZNF217 might play a crucial role in the proliferation and invasion of ovarian cancer.
Title: Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line.
ZNF217 and its associated pathways may provide new targets for therapeutic intervention in human cancers.[REVIEW]
Title: Amplification of zinc finger gene 217 (ZNF217) and cancer: when good fingers go bad.

Submit: New GeneRIF Correction See all (14)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:113547	BioGRID:107869	CTBP1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:113547	BioGRID:107870	CTBP2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113547	BioGRID:116123	EHMT2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113547	BioGRID:109316	HDAC2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113547	BioGRID:113895	HIST3H3	BioGRID	PubMed	Biochemical Activity
BioGRID:113547	BioGRID:116667	KDM1A	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:113547	BioGRID:115984	KDM5B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113547	BioGRID:116796	RCOR1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
sequence-specific DNA binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription, DNA-dependent	TAS Traceable Author Statement more info	PubMed
transcription, DNA-dependent	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
histone deacetylase complex	IDA Inferred from Direct Assay more info	PubMed
intracellular	IEA Inferred from Electronic Annotation more info
nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: zinc finger protein 217

Names: zinc finger protein 217

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006526.2 → NP_006517.1 zinc finger protein 217

Status: VALIDATED

Source sequence(s)

AF041259, BC039055

Consensus CDS

CCDS13443.1

UniProtKB/Swiss-Prot

O75362

Related

ENSP00000304308, ENST00000302342

Conserved Domains (2) summary

pfam13465
Location:485 – 510
Blast Score: 100

zf-H2C2_2; Zinc-finger double domain

cl15478
Location:472 – 493
Blast Score: 85

zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p5 Primary Assembly

Range

52183610..52199636, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

48929869..48945895, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL157838.24	CAC08433.1
		CAC32858.1
genomic	CH471077.2	EAW75578.1
		EAW75579.1
		EAW75580.1
		EAW75581.1
mRNA	AF041259.1	AAC39895.1
mRNA	AK290350.1	BAF83039.1
mRNA	BC039055.1	None
mRNA	BC113427.1	AAI13428.1