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    TRIM26 tripartite motif containing 26 [ Homo sapiens ]

    Gene ID: 7726, updated on 11-May-2012
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    Summary

    Official Symbol
    TRIM26provided by HGNC
    Official Full Name
    tripartite motif containing 26provided by HGNC
    Primary source
    HGNC:12962
    Locus tag
    DAAP-200B17.5
    See related
    Ensembl:ENSG00000234127; HPRD:02901; MIM:600830; Vega:OTTHUMG00000031041
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AFP; RNF95; ZNF173; FLJ16483
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]
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    Genomic context

    Location :
    6p21.3
    Sequence :
    Chromosome: 6; NC_000006.11 (30152232..30181271, complement)
    See TRIM26 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 10 Neighboring gene tripartite motif containing 15 Neighboring gene poly(A) binding protein interacting protein 1 pseudogene 1 Neighboring gene tripartite motif containing 26B, pseudogene Neighboring gene major histocompatibility complex, class I, L (pseudogene)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage. Wang J, et al. Proc Natl Acad Sci U S A, 2010 Sep 14. PMID 20805509.

    See all (20) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.
    2. Higher baseline serum AFP levels independently predicted a lower sustained viral response to antivirals among patients with chronic hepatitis C.
      Title: Serum alpha-foetoprotein level predicts treatment outcome in chronic hepatitis C.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q12899 Q12899 TRIM26    HPRD  PubMed  
    BioGRID:113515 BioGRID:107481 CEBPD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113515 BioGRID:121122 MEPCE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113515 BioGRID:117071 SRRM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113515 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113515 BioGRID:113515 TRIM26    BioGRID  PubMed Two-hybrid 
    BioGRID:113515 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113515 BioGRID:113169 UBE2D1    BioGRID  PubMed Two-hybrid 
    BioGRID:113515 BioGRID:113170 UBE2D2    BioGRID  PubMed Two-hybrid 
    BioGRID:113515 BioGRID:113171 UBE2D3    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    tripartite motif-containing protein 26
    Names
    tripartite motif-containing protein 26
    acid finger protein
    RING finger protein 95
    zinc finger protein 173
    tripartite motif-containing 26
    widely expressed acid zinc finger protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242783.1 → NP_001229712.1  tripartite motif-containing protein 26

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal exon in the 5' UTR, compared to variant 1.
      Source sequence(s)
      BC032297, DA234548
      Consensus CDS
      CCDS4678.1
      UniProtKB/Swiss-Prot
      Q12899
      UniProtKB/TrEMBL
      Q5SRL2
      Related
      ENSP00000391879, OTTHUMP00000161458, ENST00000453195, OTTHUMT00000253441
      Conserved Domains (5) summary
      cd00021
      Location:101 – 138
      Blast Score: 115
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd00162
      Location:15 – 60
      Blast Score: 127
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam13923
      Location:12 – 58
      Blast Score: 133
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
      cl02614
      Location:437 – 533
      Blast Score: 208
      SPRY; SPRY domain
      cl02686
      Location:312 – 363
      Blast Score: 184
      PRY; SPRY-associated domain

    2. NM_003449.4 → NP_003440.1  tripartite motif-containing protein 26

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC024039, DA234548
      Consensus CDS
      CCDS4678.1
      UniProtKB/Swiss-Prot
      Q12899
      UniProtKB/TrEMBL
      Q5SRL2
      Related
      ENSP00000410446, OTTHUMP00000161459, ENST00000454678, OTTHUMT00000253442
      Conserved Domains (5) summary
      cd00021
      Location:101 – 138
      Blast Score: 115
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd00162
      Location:15 – 60
      Blast Score: 127
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam13923
      Location:12 – 58
      Blast Score: 133
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
      cl02614
      Location:437 – 533
      Blast Score: 208
      SPRY; SPRY domain
      cl02686
      Location:312 – 363
      Blast Score: 184
      PRY; SPRY-associated domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      30152232..30181271, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.1 Reference GRCh37.p5 ALT_REF_LOCI_1

      Range
      1392422..1421465, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.2 Reference GRCh37.p5 ALT_REF_LOCI_2

      Range
      1664341..1693371, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.1 Reference GRCh37.p5 ALT_REF_LOCI_3

      Range
      1445912..1474955, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.1 Reference GRCh37.p5 ALT_REF_LOCI_4

      Range
      1500731..1529767, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.1 Reference GRCh37.p5 ALT_REF_LOCI_5

      Range
      1534069..1562952, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.1 Reference GRCh37.p5 ALT_REF_LOCI_6

      Range
      1445147..1474192, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.1 Reference GRCh37.p5 ALT_REF_LOCI_7

      Range
      1482640..1511683, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      29950359..29979394, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB088090.1 BAC54923.1
    genomic AB103596.1 BAF31258.1
    genomic AB202086.1 BAE78607.1
    genomic AL662782.3 (2000..7183) None
    genomic AL662832.5 (1999..23898) None
    genomic AL671855.4 (21908..45644) None
    genomic AL844220.3 CAI18614.1
      CAI18615.2
    genomic AL844220.3 CAI18614.1
      CAI18615.2
    genomic AL845450.3 (21890..28902) None
    genomic BA000025.2 BAB63330.1
    genomic BX248419.4 CAM26023.1
    genomic BX927189.6 CAQ09452.1
      CAQ09454.1
    genomic BX927221.6 CAQ10305.1
    genomic CH471081.1 EAX03272.1
      EAX03273.1
      EAX03274.1
      EAX03275.1
      EAX03276.1
    genomic CR388382.5 CAQ08631.1
    genomic CR759838.4 CAQ11096.1
    genomic CR788282.3 CAQ07461.1
    mRNA AK096996.1 None
    mRNA AK122859.1 None
    mRNA AK314782.1 None
    mRNA BC021115.1 None
    mRNA BC024039.1 AAH24039.1
    mRNA BC032297.1 AAH32297.1
    mRNA CB988131.1 None
    mRNA DA234548.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12899.1 GenPept UniProtKB/Swiss-Prot:Q12899
    Q5SPU2 GenPept UniProtKB/TrEMBL:Q5SPU2
    Q5SRL2 GenPept UniProtKB/TrEMBL:Q5SRL2
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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