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    ZBTB16 zinc finger and BTB domain containing 16 [ Homo sapiens (human) ]

    Gene ID: 7704, updated on 16-Jun-2013
    Official Symbol
    ZBTB16provided by HGNC
    Official Full Name
    zinc finger and BTB domain containing 16provided by HGNC
    Primary source
    HGNC:12930
    See related
    Ensembl:ENSG00000109906; HPRD:11762; MIM:176797; Vega:OTTHUMG00000168243
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PLZF; ZNF145
    Summary
    This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
    Location :
    11q23.1
    Sequence :
    Chromosome: 11; NC_000011.9 (113930431..114121398)
    See ZBTB16 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic Neighboring gene 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic Neighboring gene nicotinamide N-methyltransferase Neighboring gene chromosome 11 open reading frame 71

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Identification of a novel promyelocytic leukemia zinc-finger isoform required for colorectal cancer cell growth and survival. Jones C, et al. Int J Cancer, 2013 Jul. PMID 23280881.
    2. Human iNKT and MAIT cells exhibit a PLZF-dependent proapoptotic propensity that is counterbalanced by XIAP. Gérart S, et al. Blood, 2013 Jan 24. PMID 23223428.
    3. Protein interactions of the transcription factor Hoxa1. Lambert B, et al. BMC Dev Biol, 2012 Oct 22. PMID 23088713.
    4. Expression of the promyelocytic leukemia zinc-finger in T-lymphoblastic lymphoma and leukemia has strong implications for their cellular origin and greater association with initial bone marrow involvement. Jeon YK, et al. Mod Pathol, 2012 Sep. PMID 22555178.
    5. Far-infrared therapy induces the nuclear translocation of PLZF which inhibits VEGF-induced proliferation in human umbilical vein endothelial cells. Hsu YH, et al. PLoS One, 2012. PMID 22292015.

    See all (106) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The p65 PLZF isoform is crucial to maintain colorectal cancer cell growth, adhesion and survival, and must occur independently of the traditionally viewed transcriptional role of PLZF in the course of these biological processes.
      Title: Identification of a novel promyelocytic leukemia zinc-finger isoform required for colorectal cancer cell growth and survival.
    2. Our findings identify a previously unknown pathway of regulation of innate-like T-cell homeostasis depending on XIAP and PLZF.
      Title: Human iNKT and MAIT cells exhibit a PLZF-dependent proapoptotic propensity that is counterbalanced by XIAP.
    3. Expression of the promyelocytic leukemia zinc-finger in T-lymphoblastic lymphoma and leukemia has strong implications for their cellular origin and greater association with initial bone marrow involvement.
      Title: Expression of the promyelocytic leukemia zinc-finger in T-lymphoblastic lymphoma and leukemia has strong implications for their cellular origin and greater association with initial bone marrow involvement.
    4. Far infrared rays induce the nuclear translocation of PLZF which inhibits VEGF-induced proliferation in HUVECs.
      Title: Far-infrared therapy induces the nuclear translocation of PLZF which inhibits VEGF-induced proliferation in human umbilical vein endothelial cells.
    5. PLZF appears to control the development and/or function of a wide variety of human lymphocytes that represent more than 10% of the total PBMCs.
      Title: Altered development of NKT cells, γδ T cells, CD8 T cells and NK cells in a PLZF deficient patient.
    6. Small interfering RNA-mediated gene silencing of ZNF145 slowed down chondrogenesis, whereas overexpression of ZNF145 enhanced chondrogenesis.
      Title: Zinc-finger protein 145, acting as an upstream regulator of SOX9, improves the differentiation potential of human mesenchymal stem cells for cartilage regeneration and repair.
    7. Although PLZF is known to direct the effector program of natural killer (NK)T cells, this study shows that CD1d naive-like cells express it at a significantly lower amount than NKT cells.
      Title: A naive-like population of human CD1d-restricted T cells expressing intermediate levels of promyelocytic leukemia zinc finger.
    8. CUX1 interacts in vivo with multiple DNA-binding sites in the 5'-UTR and promoter of the PLZF gene in colorectal cancer cells
      Title: The Promyelocytic Leukemia Zinc Finger (PLZF ) gene is a novel transcriptional target of the CCAAT-Displacement-protein (CUX1) repressor.
    9. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    10. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction See all (53)

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001018011.1 NP_000312.1 RB1    BIND  PubMed pRB interacts with PLZF. 
    NP_005997.2 NP_004955.2 HDAC1    BIND  PubMed HDAC1 interacts with PLZF. This interaction was modelled on a demonstrated interaction between HDAC1 and PLZF from unspecified species. 
    NP_005997.2 NP_006303.1 NCOR2    BIND  PubMed SMRT interacts with PLZF. This interaction was modelled on a demonstrated interaction between SMRT and PLZF from unspecified species. 
    NP_005997.2 NP_056292.1 SIN3A    BIND  PubMed Sin3A interacts with PLZF. This interaction was modelled on a demonstrated interaction between mSin3A and PLZF from unspecified species. 
    Q05516 P13686 ACP5    HPRD  PubMed  
    Q05516 P50052 AGTR2    HPRD  PubMed  
    Q05516 Q9UJX4 ANAPC5    HPRD  PubMed  
    Q05516 P35670 ATP7B    HPRD  PubMed  
    Q05516 P41182 BCL6    HPRD  PubMed  
    Q05516 P35226 BMI1    HPRD  PubMed  
    Q05516 Q9NWR8 CCDC109B    HPRD  PubMed  
    Q05516 P13994 CCDC130    HPRD  PubMed  
    Q05516 Q15834 CCDC85B    HPRD  PubMed  
    Q05516 P60033 CD81    HPRD  PubMed  
    Q05516 P06493 CDK1    HPRD  PubMed  
    Q05516 Q8NHQ1 CEP70    HPRD  PubMed  
    Q05516 Q9P209 CEP72    HPRD  PubMed  
    Q05516 O60543 CIDEA    HPRD  PubMed  
    Q05516 Q9Y2Z9 COQ6    HPRD  PubMed  
    Q05516 P36957 DLST    HPRD  PubMed  
    Q05516 O60762 DPM1    HPRD  PubMed  
    Q05516 P68104 EEF1A1    HPRD  PubMed  
    Q05516 P20042 EIF2S2    HPRD  PubMed  
    Q05516 Ecto-NOX disulfide-thiol exchanger 1 ENOX1    HPRD  PubMed  
    Q05516 Q09472 EP300    HPRD  PubMed  
    Q05516 Q9Y6I3 EPN1    HPRD  PubMed  
    Q05516 P03372 ESR1    HPRD  PubMed  
    Q05516 Q8N5W9 FAM101B    HPRD  PubMed  
    Q05516 O14526 FCHO1    HPRD  PubMed  
    Q05516 Q14192 FHL2    HPRD  PubMed  
    Q05516 P23945 FSHR    HPRD  PubMed  
    Q05516 P15976 GATA1    HPRD  PubMed  
    Q05516 P23769 GATA2    HPRD  PubMed  
    Q05516 P23434 GCSH    HPRD  PubMed  
    Q05516 Q9Y223 GNE    HPRD  PubMed  
    Q05516 Q03013 GSTM4    HPRD  PubMed  
    Q05516 Q99075 HBEGF    HPRD  PubMed  
    Q05516 Q13547 HDAC1    HPRD  PubMed  
    Q05516 P56524 HDAC4    HPRD  PubMed  
    Q05516 Q9UQL6 HDAC5    HPRD  PubMed  
    Q05516 Q9UBN7 HDAC6    HPRD  PubMed  
    Q05516 Q8WUI4 HDAC7    HPRD  PubMed  
    Q05516 Q9UKV0 HDAC9    HPRD  PubMed  
    Q05516 Q86Y56 HEATR2    HPRD  PubMed  
    Q05516 P32942 ICAM3    HPRD  PubMed  
    Q05516 P05231 IL6    HPRD  PubMed  
    Q05516 Q9BQ66 KRTAP4-12    HPRD  PubMed  
    Q05516 O43504 LAMTOR5    HPRD  PubMed  
    Q05516 O95751 LDOC1    HPRD  PubMed  
    Q05516 Q9Y333 LSM2    HPRD  PubMed  
    Q05516 LYAR LYAR    HPRD  PubMed  
    Q05516 P43364 MAGEA11    HPRD  PubMed  
    Q05516 Q99759 MAP3K3    HPRD  PubMed  
    Q05516 O75376 NCOR1    HPRD  PubMed  
    Q05516 Q9Y618 NCOR2    HPRD  PubMed  
    Q05516 P04150 NR3C1    HPRD  PubMed  
    Q05516 Q15102 PAFAH1B3    HPRD  PubMed  
    Q05516 Bcl XL binding protein v68 PGAM5    HPRD  PubMed  
    Q05516 O15162 PLSCR1    HPRD  PubMed  
    Q05516 Q13794 PMAIP1    HPRD  PubMed  
    Q05516 P29590 PML    HPRD  PubMed  
    Q05516 Q9NPJ4 PNRC2    HPRD  PubMed  
    Q05516 O00231 PSMD11    HPRD  PubMed  
    Q05516 Q13200 PSMD2    HPRD  PubMed  
    Q05516 Q9BXR0 QTRT1    HPRD  PubMed  
    Q05516 P51159 RAB27A    HPRD  PubMed  
    Q05516 P10276 RARA    HPRD  PubMed  
    Q05516 P06400 RB1    HPRD  PubMed  
    Q05516 Q06455 RUNX1T1    HPRD  PubMed  
    Q05516 P19793 RXRA    HPRD  PubMed  
    Q05516 Q96ST3 SIN3A    HPRD  PubMed  
    Q05516 O75182 SIN3B    HPRD  PubMed  
    Q05516 P84022 SMAD3    HPRD  PubMed  
    Q05516 P08047 SP1    HPRD  PubMed  
    Q05516 O43791 SPOP    HPRD  PubMed  
    Q05516 P54274 TERF1    HPRD  PubMed  
    Q05516 Threonine synthase-like 2 THNSL2    HPRD  PubMed  
    Q05516 Q9H0E2 TOLLIP    HPRD  PubMed  
    Q05516 Q12933 TRAF2    HPRD  PubMed  
    Q05516 P14373 TRIM27    HPRD  PubMed  
    Q05516 Q9H3M7 TXNIP    HPRD  PubMed  
    Q05516 P11473 VDR    HPRD  PubMed  
    Q05516 Q9NP79 VTA1    HPRD  PubMed  
    Q05516 Q9C0J8 WDR33    HPRD  PubMed  
    Q05516 Q05516 ZBTB16    HPRD  PubMed  
    Q05516 Q9Y2Y4 ZBTB32    HPRD  PubMed  
    Q05516 P17028 ZNF24    HPRD  PubMed  
    Q05516 KIAA1549 protein     HPRD  PubMed  
    BioGRID:113498 BioGRID:114885 ADAMTS4    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:106691 AGTR1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113498 BioGRID:119537 ANAPC5    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:106807 ANXA7    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:106862 AR    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:115461 ATP6AP2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113498 BioGRID:107022 ATP7B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113498 BioGRID:107076 BCL6    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113498 BioGRID:107116 BMI1    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:113498 BioGRID:107286 CASP3    BioGRID  PubMed Biochemical Activity 
    BioGRID:113498 BioGRID:120345 CCDC109B    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:123536 CCDC130    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:116198 CCDC85B    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:107413 CD81    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:107420 CDK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113498 BioGRID:107454 CDK4    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:107460 CDKN1A    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:123234 CEP70    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:120844 CEP72    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:109324 CFH    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:107570 CIDEA    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:119212 COQ6    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:108087 DLST    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:108122 DNM2    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:114340 DPM1    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:108237 EEF1A1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113498 BioGRID:114411 EIF2S2    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:120385 ENOX1    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113498 BioGRID:108403 ESR1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113498 BioGRID:131787 FAM101B    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:116764 FCHO1    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:108565 FHL2    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement; Phenotypic Suppression; Reconstituted Complex; Two-hybrid 
    BioGRID:113498 BioGRID:108566 FHL3    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:113498 BioGRID:108770 FSHR    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:108893 GATA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113498 BioGRID:108894 GATA2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113498 BioGRID:108923 GCSH    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:109143 GRB7    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:109203 GSTM4    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:248412 Gnao1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113498 BioGRID:250408 Gne    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113498 BioGRID:108172 HBEGF    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113498 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113498 BioGRID:109316 HDAC2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113498 BioGRID:114368 HDAC3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113498 BioGRID:115106 HDAC4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113498 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113498 BioGRID:115330 HDAC6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113498 BioGRID:119613 HDAC7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113498 BioGRID:126559 HDX    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:120260 HEATR2    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:109438 HOXA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113498 BioGRID:200362 Hoxa1    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:123756 KRTAP4-12    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:115796 LAMTOR5    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:117169 LDOC1    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:125345 LMTK3    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:121778 LSM2    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:120780 LYAR    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:110284 MAGEA11    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:110379 MAP3K3    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:124913 MTDH    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113498 BioGRID:114973 NCOR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113498 BioGRID:114974 NCOR2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113498 BioGRID:109165 NR3C1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113498 BioGRID:111087 PAFAH1B3    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:106652 PARP1    BioGRID  PubMed Biochemical Activity 
    BioGRID:113498 BioGRID:128154 PGAM5    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:111373 PLSCR1    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:111379 PMAIP1    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:111384 PML    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113498 BioGRID:111689 PSMD11    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:111681 PSMD2    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:123623 QTRT1    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:111811 RAB27A    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:111849 RARA    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113498 BioGRID:107310 RUNX1T1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113498 BioGRID:117439 SIN3A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113498 BioGRID:116901 SIN3B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113498 BioGRID:110263 SMAD3    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:112490 SMN1    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:113993 SPOP    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:115547 SPRY2    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid 
    BioGRID:113498 BioGRID:203414 Sp1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113498 BioGRID:116740 TAB2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113498 BioGRID:112872 TERF1    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:120549 THNSL2    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:112932 TIMP1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113498 BioGRID:112938 TK1    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:115485 TNK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113498 BioGRID:119978 TOLLIP    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:113038 TRAF2    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:111919 TRIM27    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:115872 TXNIP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113498 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113498 BioGRID:113177 UBE2I    BioGRID  PubMed Biochemical Activity; Two-hybrid 
    BioGRID:113498 BioGRID:113264 VDR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113498 BioGRID:119595 VTA1    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:120620 WDR33    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:113498 ZBTB16    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex 
    BioGRID:113498 BioGRID:117964 ZBTB32    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113498 BioGRID:113403 ZNF24    BioGRID  PubMed Two-hybrid 
    BioGRID:113498 BioGRID:117074 ZNF281    BioGRID  PubMed Two-hybrid 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
    		  
    apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cartilage development IDA
    Inferred from Direct Assay
    more info
    		  
    central nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    embryonic hindlimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    embryonic pattern specification IEA
    Inferred from Electronic Annotation
    more info
    		  
    forelimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    hemopoiesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    hemopoiesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    male germ-line stem cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    mesonephros development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    myeloid cell differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of myeloid cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cartilage development IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of ossification IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		  
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    PML body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcriptional repressor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    zinc finger and BTB domain-containing protein 16
    Names
    zinc finger and BTB domain-containing protein 16
    zinc finger protein PLZF
    zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012140.1 RefSeqGene

      Range
      5001..195968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018011.1 → NP_001018011.1  zinc finger and BTB domain-containing protein 16

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC026902, BM969145
      Consensus CDS
      CCDS8367.1
      UniProtKB/Swiss-Prot
      Q05516
      Related
      ENSP00000376721, OTTHUMP00000238382, ENST00000392996, OTTHUMT00000398944
      Conserved Domains (5) summary
      COG5048
      Location:448 – 587
      Blast Score: 96
      COG5048; FOG: Zn-finger [General function prediction only]
      pfam00651
      Location:25 – 122
      Blast Score: 218
      BTB; BTB/POZ domain
      pfam13465
      Location:561 – 584
      Blast Score: 100
      zf-H2C2_2; Zinc-finger double domain
      pfam13912
      Location:461 – 483
      Blast Score: 79
      zf-C2H2_6; C2H2-type zinc finger
      cl15478
      Location:518 – 540
      Blast Score: 82
      zf-C2H2; Zinc finger, C2H2 type

    2. NM_006006.4 → NP_005997.2  zinc finger and BTB domain-containing protein 16

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC029812, BM969145, BX648973
      Consensus CDS
      CCDS8367.1
      UniProtKB/Swiss-Prot
      Q05516
      Related
      ENSP00000338157, OTTHUMP00000238379, ENST00000335953, OTTHUMT00000398940
      Conserved Domains (5) summary
      COG5048
      Location:448 – 587
      Blast Score: 96
      COG5048; FOG: Zn-finger [General function prediction only]
      pfam00651
      Location:25 – 122
      Blast Score: 218
      BTB; BTB/POZ domain
      pfam13465
      Location:561 – 584
      Blast Score: 100
      zf-H2C2_2; Zinc-finger double domain
      pfam13912
      Location:461 – 483
      Blast Score: 79
      zf-C2H2_6; C2H2-type zinc finger
      cl15478
      Location:518 – 540
      Blast Score: 82
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p10 Primary Assembly

      Range
      113930431..114121398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      109859046..110049950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018922.1 Alternate CHM1_1.0

      Range
      113793792..113984882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01039773.1 (40041..171754) None
    genomic ABBA01039774.1 None
    genomic AF060568.1 AAD03619.1
    genomic AF076613.1 AAC32847.1
    genomic AF076615.1 AAC32848.1
    genomic AF076616.1 AAC32849.1
    genomic AMYH01004040.1 (233380..322077) None
    genomic AMYH01004041.1 None
    genomic AMYH01004042.1 None
    genomic AP000908.4 (109922..149132) None
    genomic AP002518.3 None
    genomic AP002755.2 (2007..109322) None
    genomic CH471065.1 EAW67241.1
      EAW67242.1
    genomic S60093.1 AAC60590.2
    mRNA AB208916.1 BAD92153.1
    mRNA AK126422.1 None
    mRNA BC026902.1 AAH26902.1
    mRNA BC029812.1 AAH29812.1
    mRNA BM969145.1 None
    mRNA BX648973.1 None
    mRNA Z19002.1 CAA79489.1
    other-genetic EU446725.1 ABZ92254.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05516.2 GenPept UniProtKB/Swiss-Prot:Q05516

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • ClinVar
        Related medical variations
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • MedGen
        Related information in MedGen
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • SNP: VarView
        Related Clinical SNP
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

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