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ZBTB16 zinc finger and BTB domain containing 16 [ Homo sapiens (human) ]

Gene ID: 7704, updated on 25-Jul-2014
Official Symbol
ZBTB16provided by HGNC
Official Full Name
zinc finger and BTB domain containing 16provided by HGNC
Primary source
HGNC:12930
See related
Ensembl:ENSG00000109906; HPRD:11762; MIM:176797; Vega:OTTHUMG00000168243
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLZF; ZNF145
Summary
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
See ZBTB16 in Epigenomics, MapViewer
Location:
11q23.1
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (114059567..114250676)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (113930289..114126702)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic Neighboring gene 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic Neighboring gene uncharacterized LOC101928875 Neighboring gene uncharacterized LOC101928916 Neighboring gene nicotinamide N-methyltransferase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Skeletal defects, genital hypoplasia, and mental retardation
MedGen: C2676231 OMIM: 612447 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of zinc finger and BTB domain containing 16 (ZBTB16) in Vif-expression T cells PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
cartilage development IDA
Inferred from Direct Assay
more info
 
central nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic hindlimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic pattern specification IEA
Inferred from Electronic Annotation
more info
 
forelimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
hemopoiesis IDA
Inferred from Direct Assay
more info
PubMed 
hemopoiesis TAS
Traceable Author Statement
more info
PubMed 
male germ-line stem cell asymmetric division IEA
Inferred from Electronic Annotation
more info
 
mesonephros development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
myeloid cell differentiation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of myeloid cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cartilage development IDA
Inferred from Direct Assay
more info
 
positive regulation of chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of ossification IDA
Inferred from Direct Assay
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
 
protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PML body IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
transcriptional repressor complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
zinc finger and BTB domain-containing protein 16
Names
zinc finger and BTB domain-containing protein 16
zinc finger protein PLZF
promyelocytic leukaemia zinc finger
zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012140.1 

    Range
    5001..195968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018011.1NP_001018011.1  zinc finger and BTB domain-containing protein 16

    See proteins identical to NP_001018011.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC026902, BM969145
    Consensus CDS
    CCDS8367.1
    UniProtKB/Swiss-Prot
    Q05516
    Related
    ENSP00000376721, OTTHUMP00000238382, ENST00000392996, OTTHUMT00000398944
    Conserved Domains (4) summary
    smart00355
    Location:518540
    Blast Score: 81
    ZnF_C2H2; zinc finger
    COG5048
    Location:448622
    Blast Score: 133
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00651
    Location:25125
    Blast Score: 219
    BTB; BTB/POZ domain
    pfam13465
    Location:561584
    Blast Score: 104
    zf-H2C2_2; Zinc-finger double domain
  2. NM_006006.4NP_005997.2  zinc finger and BTB domain-containing protein 16

    See proteins identical to NP_005997.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC029812, BM969145, BX648973
    Consensus CDS
    CCDS8367.1
    UniProtKB/Swiss-Prot
    Q05516
    Related
    ENSP00000338157, OTTHUMP00000238379, ENST00000335953, OTTHUMT00000398940
    Conserved Domains (4) summary
    smart00355
    Location:518540
    Blast Score: 81
    ZnF_C2H2; zinc finger
    COG5048
    Location:448622
    Blast Score: 133
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00651
    Location:25125
    Blast Score: 219
    BTB; BTB/POZ domain
    pfam13465
    Location:561584
    Blast Score: 104
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 

    Range
    114059567..114250676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718899.1XP_006718962.1  

    Conserved Domains (2) summary
    pfam00651
    Location:25106
    Blast Score: 223
    BTB; BTB/POZ domain
    pfam13912
    Location:461483
    Blast Score: 87
    zf-C2H2_6; C2H2-type zinc finger
  2. XM_005271658.2XP_005271715.1  

    Conserved Domains (2) summary
    pfam00651
    Location:25106
    Blast Score: 223
    BTB; BTB/POZ domain
    pfam13912
    Location:461483
    Blast Score: 87
    zf-C2H2_6; C2H2-type zinc finger

Alternate HuRef

Genomic

  1. AC_000143.1 

    Range
    109859046..110049950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 

    Range
    113814520..114005500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)