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ZNF143 zinc finger protein 143 [ Homo sapiens (human) ]

Gene ID: 7702, updated on 26-May-2016
Official Symbol
ZNF143provided by HGNC
Official Full Name
zinc finger protein 143provided by HGNC
Primary source
HGNC:HGNC:12928
See related
Ensembl:ENSG00000166478 HPRD:04578; MIM:603433; Vega:OTTHUMG00000149922
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SBF; STAF; pHZ-1
Orthologs
Location:
11p15.4
Exon count:
18
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (9460965..9528524)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (9482512..9550071)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene importin 7 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene uncharacterized LOC644656 Neighboring gene uncharacterized LOC105376543 Neighboring gene WEE1 G2 checkpoint kinase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 
Preferred Names
zinc finger protein 143
Names
SPH-binding factor
hStaf
selenocysteine tRNA gene transcription-activating factor
transcriptional activator Staf
NP_001269585.1
NP_001269586.1
NP_003433.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282656.1NP_001269585.1  zinc finger protein 143 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AK297214, AK313330, BF515092, BG825506, CN295530
    Consensus CDS
    CCDS60720.1
    UniProtKB/Swiss-Prot
    P52747
    Related
    ENSP00000432154, OTTHUMP00000231211, ENST00000530463, OTTHUMT00000386579
    Conserved Domains (3) summary
    COG5048
    Location:250423
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:312339
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:238260
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001282657.1NP_001269586.1  zinc finger protein 143 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AK297214, BC014458, BF515092, BG825506, CN295530
    Consensus CDS
    CCDS60721.1
    UniProtKB/Swiss-Prot
    P52747
    Related
    ENSP00000379843, OTTHUMP00000231214, ENST00000396597, OTTHUMT00000386582
    Conserved Domains (4) summary
    COG5048
    Location:220393
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:282309
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:208230
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl00342
    Location:51161
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  3. NM_003442.5NP_003433.3  zinc finger protein 143 isoform 1

    See identical proteins and their annotated locations for NP_003433.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK297214, AW162015, BC020219, BG825506
    Consensus CDS
    CCDS7799.2
    UniProtKB/Swiss-Prot
    P52747
    Related
    ENSP00000379847, OTTHUMP00000195124, ENST00000396602, OTTHUMT00000313921
    Conserved Domains (4) summary
    COG5048
    Location:251424
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:313340
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:239261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl00342
    Location:82192
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    9460965..9528524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253122.1XP_005253179.1  

    Conserved Domains (3) summary
    COG5048
    Location:265438
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:327354
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:253275
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_005253127.1XP_005253184.1  

    Conserved Domains (3) summary
    COG5048
    Location:48221
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:110137
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:3658
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_005253121.1XP_005253178.1  

    Conserved Domains (4) summary
    COG5048
    Location:266439
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:328355
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:254276
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl00342
    Location:97207
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  4. XM_005253126.1XP_005253183.1  

    Conserved Domains (4) summary
    COG5048
    Location:310385
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:328354
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:254276
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl00342
    Location:97207
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  5. XM_011520349.1XP_011518651.1  

    See identical proteins and their annotated locations for XP_011518651.1

    UniProtKB/Swiss-Prot
    P52747
    Conserved Domains (4) summary
    COG5048
    Location:251424
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:313340
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:239261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl00342
    Location:82192
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    9481437..9549032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)