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    CA11 carbonic anhydrase XI [ Homo sapiens ]

    Gene ID: 770, updated on 11-May-2012
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    Summary

    Official Symbol
    CA11provided by HGNC
    Official Full Name
    carbonic anhydrase XIprovided by HGNC
    Primary source
    HGNC:1370
    Locus tag
    UNQ211/PRO237
    See related
    Ensembl:ENSG00000063180; HPRD:05225; MIM:604644
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CARPX1
    Summary
    Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    19q13.3
    Sequence :
    Chromosome: 19; NC_000019.9 (49141272..49149451, complement)
    See CA11 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene sphingosine kinase 2 Neighboring gene D site of albumin promoter (albumin D-box) binding protein Neighboring gene secretory blood group 1 Neighboring gene netrin 5 Neighboring gene fucosyltransferase 2 (secretor status included)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo. Ikram MK, et al. PLoS Genet, 2010 Oct 28. PMID 21060863.
    2. CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation. Liao W, et al. Curr Biol, 2008 May 6. PMID 18450452.
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. Liu T, et al. J Proteome Res, 2005 Nov-Dec. PMID 16335952.
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309.

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:107224 BioGRID:114274 RIPK1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT carbonate dehydratase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    carbonic anhydrase-related protein 11
    Names
    carbonic anhydrase-related protein 11
    CA-XI
    CARP-2
    CARP XI
    CA-RP II
    carbonic anhydrase-related protein 2
    carbonic anhydrase-related protein XI
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001217.3 → NP_001208.2  carbonic anhydrase-related protein 11 precursor

      Status: REVIEWED

      Source sequence(s)
      AF067662, AY358967, BX440526
      Consensus CDS
      CCDS12729.1
      UniProtKB/Swiss-Prot
      O75493
      Related
      ENSP00000084798, ENST00000084798
      Conserved Domains (1) summary
      cd03121
      Location:48 – 304
      Blast Score: 984
      alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      49141272..49149451, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      45520726..45528907, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC008888.7 (17407..25586) None
    genomic CH471177.1 EAW52376.1
      EAW52377.1
      EAW52378.1
    mRNA AB018195.1 BAA36840.1
    mRNA AF050106.1 AAD08802.1
    mRNA AF067662.1 AAC99689.1
    mRNA AY358967.1 AAQ89326.1
    mRNA BC002662.2 AAH02662.1
    mRNA BT007265.1 AAP35929.1
    mRNA BX440526.2 None
    mRNA CR541772.1 CAG46571.1
    other-genetic EU832340.1 ACE87597.1
    other-genetic EU832425.1 ACE86910.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75493.2 GenPept UniProtKB/Swiss-Prot:O75493
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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