Dtl denticleless homolog (Drosophila) [Mus musculus] - Gene

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Summary

Official Symbol: Dtlprovided by MGI
Official Full Name: denticleless homolog (Drosophila)provided by MGI
Primary source: MGI:1924093
See related: Ensembl:ENSMUSG00000037474
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ramp; 2810047L02Rik; 5730564G15Rik

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Genomic context

Location :: 1 H6; 1

Sequence :: Chromosome: 1; NC_000067.6 (191537365..191575534, complement)

See Dtl in Epigenomics, MapViewer

Chromosome 1 - NC_000067.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

L2dtl gene expression is essential for very early mouse embryonic development
Title: L2dtl is essential for cell survival and nuclear division in early mouse embryonic development.

Submit: New GeneRIF Correction

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:218345	BioGRID:114729	COPS2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:218345	BioGRID:119324	COPS4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:218345	BioGRID:116176	COPS6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:218345	BioGRID:114029	CUL4A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:218345	BioGRID:114028	CUL4B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:218345	BioGRID:108009	DDB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:218345	BioGRID:119582	DTL	BioGRID	PubMed	Affinity Capture-MS

Process	Evidence Code	Pubs
DNA replication	IEA Inferred from Electronic Annotation more info
G2/M transition DNA damage checkpoint	ISO Inferred from Sequence Orthology more info
protein monoubiquitination	ISO Inferred from Sequence Orthology more info
protein polyubiquitination	ISO Inferred from Sequence Orthology more info
regulation of cell cycle	ISO Inferred from Sequence Orthology more info
response to DNA damage stimulus	ISO Inferred from Sequence Orthology more info
response to UV	ISO Inferred from Sequence Orthology more info
translesion synthesis	ISO Inferred from Sequence Orthology more info
ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
Cul4A-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
Cul4B-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
centrosome	ISO Inferred from Sequence Orthology more info
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
nucleus	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: denticleless protein homolog

Names: denticleless protein homolog; Meth A ramp; lethal(2) denticleless protein homolog; retinoic acid-regulated nuclear matrix-associated protein; retinoic-acid regulated nuclear matrix-associated protein; meth A retinoic acid-regulated nuclear matrix-associated protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029766.2 → NP_084042.1 denticleless protein homolog

Status: VALIDATED

Source sequence(s)

AC132830, AK054412, CF898098

Consensus CDS

CCDS15621.1

UniProtKB/Swiss-Prot

Q3TLR7

Related

ENSMUSP00000027933, ENSMUST00000027933

Conserved Domains (1) summary

cd00200
Location:65 – 389
Blast Score: 320

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000067.6 Reference GRCm38 C57BL/6J

Range

191537365..191575534, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000023.1 Alternate Mm_Celera

Range

198486790..198526178, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC132830.12 (107895..146064)	None
genomic	CH466555.2	EDL12988.1	mixed
		EDL12989.1	mixed
		EDL12990.1	mixed
mRNA	AB095735.1	BAC76404.1	BALB/c
mRNA	AB095736.1	BAC76405.1	BALB/c
mRNA	AK012919.1	BAB28549.1	C57BL/6J
mRNA	AK017855.1	None	C57BL/6J
mRNA	AK045014.1	None	C57BL/6J
mRNA	AK054412.1	BAC35769.1	C57BL/6J
mRNA	AK133177.1	BAE21543.1	C57BL/6J
mRNA	AK154594.1	None	NOD
mRNA	AK161401.1	BAE36376.1	C57BL/6J
mRNA	AK164249.1	None	C57BL/6J
mRNA	AK164999.1	None	C57BL/6J
mRNA	AK166351.1	BAE38725.1
mRNA	AK169601.1	None	NOD
mRNA	BC060208.1	None	C57BL/6
mRNA	CF898098.1	None	C57BL/6
mRNA	DQ715636.1	None