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Senp2 SUMO/sentrin specific peptidase 2 [ Mus musculus (house mouse) ]

Gene ID: 75826, updated on 8-May-2016
Official Symbol
Senp2provided by MGI
Official Full Name
SUMO/sentrin specific peptidase 2provided by MGI
Primary source
MGI:MGI:1923076
See related
Ensembl:ENSMUSG00000022855
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SuPr-1; Smt3ip2; AI646780; AW554757; mKIAA1331; 2310007L05Rik; 4930538C18Rik
Orthologs
Location:
16; 16 B1
Exon count:
17
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 16 NC_000082.6 (22009432..22049269)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (22009557..22049342)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 41a Neighboring gene lipase, member H Neighboring gene predicted pseudogene 4943 Neighboring gene insulin-like growth factor 2 mRNA binding protein 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1331

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SUMO-specific endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
SUMO-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
SUMO-specific protease activity ISO
Inferred from Sequence Orthology
more info
 
cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
dorsal/ventral axis specification ISO
Inferred from Sequence Orthology
more info
 
fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
labyrinthine layer development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of chromatin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
negative regulation of signal transduction by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein destabilization ISO
Inferred from Sequence Orthology
more info
 
protein desumoylation IDA
Inferred from Direct Assay
more info
PubMed 
protein desumoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein desumoylation ISO
Inferred from Sequence Orthology
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of DNA endoreduplication IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
spongiotrophoblast layer development IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
trophoblast giant cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with PML body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
sentrin-specific protease 2
Names
SUMO-1 protease 1
SUMO-1 protease-1
SUMO-1/Smt3-specific isopeptidase 2
SUMO/sentrin specific protease 2
axam2
sentrin/SUMO-specific protease SENP2
NP_083733.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029457.3NP_083733.1  sentrin-specific protease 2

    See identical proteins and their annotated locations for NP_083733.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AK031030, CJ169147, CT009567, CT030725
    Consensus CDS
    CCDS28065.1
    UniProtKB/Swiss-Prot
    Q91ZX6
    Related
    ENSMUSP00000023561, ENSMUST00000023561
    Conserved Domains (1) summary
    cl17784
    Location:337583
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

RNA

  1. NR_027488.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of a coding exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF368904, AK031030, CJ169147, CT009567, CT030725

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p3 C57BL/6J

    Range
    22009432..22049269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522688.1XP_006522751.1  

    Conserved Domains (1) summary
    cl17784
    Location:372588
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  2. XM_006522689.2XP_006522752.1  

    Conserved Domains (1) summary
    cl17784
    Location:325541
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  3. XM_006522690.1XP_006522753.1  

    See identical proteins and their annotated locations for XP_006522753.1

    UniProtKB/Swiss-Prot
    Q91ZX6
    Conserved Domains (1) summary
    cl17784
    Location:256502
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

Alternate Mm_Celera

Genomic

  1. AC_000038.1 Alternate Mm_Celera

    Range
    22576818..22616603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)