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    ZNF24 zinc finger protein 24 [ Homo sapiens ]

    Gene ID: 7572, updated on 11-May-2012
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    Summary

    Official Symbol
    ZNF24provided by HGNC
    Official Full Name
    zinc finger protein 24provided by HGNC
    Primary source
    HGNC:13032
    See related
    Ensembl:ENSG00000172466; HPRD:01921; MIM:194534; Vega:OTTHUMG00000132565
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX17; RSG-A; ZNF191; ZSCAN3; Zfp191
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    Genomic context

    Location :
    18q12
    Sequence :
    Chromosome: 18; NC_000018.9 (32912178..32924426, complement)
    See ZNF24 in Epigenomics, MapViewer

    Chromosome 18 - NC_000018.9Genomic Context describing neighboring genes Neighboring gene zinc finger protein 397 Neighboring gene zinc finger and SCAN domain containing 30 Neighboring gene zinc finger protein 271 Neighboring gene zinc finger protein 396 Neighboring gene ribosomal protein L7a pseudogene 67

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Comparative proteomic analysis identifies a role for SUMO in protein quality control. Tatham MH, et al. Sci Signal, 2011 Jun 21. PMID 21693764.
    3. Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. Rowbotham SP, et al. Mol Cell, 2011 May 6. PMID 21549307.
    4. Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes. Engelen E, et al. Nat Genet, 2011 Jun. PMID 21532573.
    5. Network organization of the human autophagy system. Behrends C, et al. Nature, 2010 Jul 1. PMID 20562859.

    See all (27) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. These data suggest that ZNF24 is involved in negative regulation of PDGFR-beta and may represent a novel repressor of PDGFR-beta transcription.
      Title: The transcriptional repression of platelet-derived growth factor receptor-beta by the zinc finger transcription factor ZNF24.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: A Large-scale genetic association study of esophageal adenocarcinoma risk.
    3. Data confirm ZNF191 as an essential factor acting for the promotion of the cell cycle and thus maintenance in the progenitor stage.
      Title: Zinc finger protein 191 (ZNF191/Zfp191) is necessary to maintain neural cells as cycling progenitors.
    4. ZNF191 is a pleiotropic factor that has a role in hematopoiesis, brain development, and tumor growth.
      Title: A transcript profiling approach reveals the zinc finger transcription factor ZNF191 is a pleiotropic factor.
    5. Overexpression and purification of single zinc finger peptides of ZNF191 were performed.
      Title: Overexpression and purification of single zinc finger peptides of human zinc finger protein ZNF191.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P17028 P51693 APLP1    HPRD  PubMed  
    P17028 Q9UKR5 C14orf1    HPRD  PubMed  
    P17028 P13994 CCDC130    HPRD  PubMed  
    P17028 Q7L5N1 COPS6    HPRD  PubMed  
    P17028 Q14194 CRMP1    HPRD  PubMed  
    P17028 P68104 EEF1A1    HPRD  PubMed  
    P17028 P26641 EEF1G    HPRD  PubMed  
    P17028 P54257 HAP1    HPRD  PubMed  
    P17028 Q92993 KAT5    HPRD  PubMed  
    P17028 Q9P2H0 KIAA1377    HPRD  PubMed  
    P17028 Q5T3J3 LRIF1    HPRD  PubMed  
    P17028 Hypothetical protein DKFZp564O0523 RBM48    HPRD  PubMed  
    P17028 P57086 SCAND1    HPRD  PubMed  
    P17028 Q15047 SETDB1    HPRD  PubMed  
    P17028 P04637 TP53    HPRD  PubMed  
    P17028 Q13432 UNC119    HPRD  PubMed  
    P17028 Q9BVJ6 UTP14A    HPRD  PubMed  
    P17028 Q05516 ZBTB16    HPRD  PubMed  
    P17028 Q15697 ZNF174    HPRD  PubMed  
    P17028 Q9NX65 ZNF434    HPRD  PubMed  
    P17028 Q9NWS9 ZNF446    HPRD  PubMed  
    BioGRID:113403 BioGRID:106830 APLP1    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:116332 C14orf1    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:123536 CCDC130    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:116176 COPS6    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:107790 CRMP1    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:108237 EEF1A1    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:108257 EEF1G    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:108472 FANCA    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:114480 HAP1    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:115779 KAT5    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:123873 KBTBD7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113403 BioGRID:121617 KIAA1377    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:120905 LRIF1    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:123855 RBM48    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:119434 SCAND1    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:115202 SETDB1    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113403 BioGRID:112540 SOX2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113403 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113403 BioGRID:113010 TP53    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:113500 TRIM25    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113403 BioGRID:114548 UNC119    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:113866 USP11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113403 BioGRID:116026 UTP14A    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:113498 ZBTB16    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:113511 ZNF165    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:113516 ZNF174    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:113529 ZNF192    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:120265 ZNF434    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:120795 ZNF446    BioGRID  PubMed Two-hybrid 
    BioGRID:113403 BioGRID:114736 ZNHIT3    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    viral reproduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
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    General protein information

    Preferred Names
    zinc finger protein 24
    Names
    zinc finger protein 24
    zinc finger protein 191
    lacks zinc finger domain
    zinc finger protein KOX17
    zinc finger protein 24 (KOX 17)
    retinoic acid suppression protein A
    zinc finger and SCAN domain-containing protein 3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006965.2 → NP_008896.2  zinc finger protein 24

      Status: VALIDATED

      Source sequence(s)
      AC116447
      Consensus CDS
      CCDS11912.1
      UniProtKB/Swiss-Prot
      P17028
      Related
      ENSP00000261332, OTTHUMP00000163383, ENST00000261332, OTTHUMT00000255769
      Conserved Domains (3) summary
      cd07936
      Location:48 – 130
      Blast Score: 338
      SCAN; SCAN oligomerization domain
      pfam13465
      Location:294 – 318
      Blast Score: 103
      zf-H2C2_2; Zinc-finger double domain
      cl15478
      Location:252 – 273
      Blast Score: 77
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000018.9 Reference GRCh37.p5 Primary Assembly

      Range
      32912178..32924426, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000150.1 Alternate HuRef

      Range
      29771791..29784041, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC116447.10 (12282..24530) None
    genomic AF016052.1 AAB70216.1
    genomic CH471088.1 EAX01348.1
      EAX01349.1
      EAX01350.1
    mRNA AF038964.1 AAD19827.1
    mRNA AF542097.1 AAN40767.1
    mRNA AK021966.1 None
    mRNA AK291246.1 BAF83935.1
    mRNA BC003566.1 AAH03566.1
    mRNA BC016801.1 AAH16801.1
    mRNA BT006658.1 AAP35304.1
    mRNA CR450328.1 CAG29324.1
    mRNA U68536.1 AAB37275.1
    mRNA X52348.1 CAA36574.1
    other-genetic HQ257967.1 ADR82721.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17028.4 GenPept UniProtKB/Swiss-Prot:P17028
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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