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CNBP CCHC-type zinc finger nucleic acid binding protein [ Homo sapiens (human) ]

Gene ID: 7555, updated on 26-May-2016
Official Symbol
CNBPprovided by HGNC
Official Full Name
CCHC-type zinc finger nucleic acid binding proteinprovided by HGNC
Primary source
HGNC:HGNC:13164
See related
Ensembl:ENSG00000169714 HPRD:00311; MIM:116955
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DM2; ZNF9; CNBP1; PROMM; RNF163; ZCCHC22
Summary
This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Location:
3q21
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (129167815..129183967, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (128886658..128902810, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ISY1-RAB43 readthrough Neighboring gene RAB43, member RAS oncogene family Neighboring gene ISY1 splicing factor homolog Neighboring gene uncharacterized LOC105374101 Neighboring gene ribosomal protein S27 pseudogene 12

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ11631

Gene Ontology Provided by GOA

Function Evidence Code Pubs
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
single-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor activity, sequence-specific DNA binding TAS
Traceable Author Statement
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cholesterol biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
cellular nucleic acid-binding protein
Names
CCHC-type zinc finger, nucleic acid binding protein
cellular nucleic acid binding protein
erythroid differentiation-related
sterol regulatory element-binding protein
zinc finger protein 273
zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011902.1 RefSeqGene

    Range
    5001..21153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001127192.1NP_001120664.1  cellular nucleic acid-binding protein isoform 1

    See identical proteins and their annotated locations for NP_001120664.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC108673, AK292119, BU616793, DB027227
    Consensus CDS
    CCDS46906.1
    UniProtKB/Swiss-Prot
    P62633
    Related
    ENSP00000410769, OTTHUMP00000233225, ENST00000441626, OTTHUMT00000390200
    Conserved Domains (1) summary
    PTZ00368
    Location:54173
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
  2. NM_001127193.1NP_001120665.1  cellular nucleic acid-binding protein isoform 2

    See identical proteins and their annotated locations for NP_001120665.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant, also known as alpha variant 1, uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AC108673, BU616793, DB027227, DQ091187
    Consensus CDS
    CCDS46907.1
    UniProtKB/Swiss-Prot
    P62633
    Related
    ENSP00000399488, OTTHUMP00000233223, ENST00000451728, OTTHUMT00000390198
    Conserved Domains (1) summary
    PTZ00368
    Location:54172
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
  3. NM_001127194.1NP_001120666.1  cellular nucleic acid-binding protein isoform 4

    See identical proteins and their annotated locations for NP_001120666.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant, also known as beta variant 2, uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 4).
    Source sequence(s)
    AC108673, BU616793, DA606481, DB027227, DQ092367
    Consensus CDS
    CCDS46908.1
    UniProtKB/Swiss-Prot
    P62633
    Related
    ENSP00000400444, OTTHUMP00000233224, ENST00000446936, OTTHUMT00000390199
    Conserved Domains (1) summary
    PTZ00368
    Location:47166
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
  4. NM_001127195.1NP_001120667.1  cellular nucleic acid-binding protein isoform 5

    See identical proteins and their annotated locations for NP_001120667.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant, also known as beta variant 1, uses two alternate in-frame splice sites in the 5' and central coding regions, compared to variant 1, resulting in a shorter protein (isoform 5).
    Source sequence(s)
    AC108673, BU616793, DB027227, DQ092366
    UniProtKB/Swiss-Prot
    P62633
    Conserved Domains (1) summary
    PTZ00368
    Location:47165
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
  5. NM_001127196.1NP_001120668.1  cellular nucleic acid-binding protein isoform 6

    See identical proteins and their annotated locations for NP_001120668.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant uses two alternate in-frame splice sites in the 5' and central coding regions, compared to variant 1, resulting in a shorter protein (isoform 6).
    Source sequence(s)
    AC108673, BC014911, BU616793, DB027227
    Consensus CDS
    CCDS54637.1
    UniProtKB/Swiss-Prot
    P62633
    UniProtKB/TrEMBL
    A0A0S2Z4Q3
    Related
    ENSP00000421323, OTTHUMP00000217106, ENST00000502976, OTTHUMT00000358420
    Conserved Domains (1) summary
    PTZ00368
    Location:47164
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
  6. NM_003418.4NP_003409.1  cellular nucleic acid-binding protein isoform 3

    See identical proteins and their annotated locations for NP_003409.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in a shorter protein (isoform 3).
    Source sequence(s)
    AC108673, BC093058, BU616793, DB027227
    Consensus CDS
    CCDS3056.1
    UniProtKB/Swiss-Prot
    P62633
    UniProtKB/TrEMBL
    A0A0S2Z4K2
    Related
    ENSP00000410619, OTTHUMP00000217105, ENST00000422453, OTTHUMT00000358419
    Conserved Domains (1) summary
    PTZ00368
    Location:54171
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    129167815..129183967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    128850015..128866149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)