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ZNF3 zinc finger protein 3 [ Homo sapiens (human) ]

Gene ID: 7551, updated on 8-May-2016
Official Symbol
ZNF3provided by HGNC
Official Full Name
zinc finger protein 3provided by HGNC
Primary source
HGNC:HGNC:13089
See related
Ensembl:ENSG00000166526 HPRD:01911; MIM:194510; Vega:OTTHUMG00000154596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A8-51; HF.12; KOX25; PP838; Zfp113
Orthologs
Location:
7q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (100063847..100082548, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99661470..99680171, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375423 Neighboring gene zinc finger with KRAB and SCAN domains 1 Neighboring gene zinc finger and SCAN domain containing 21 Neighboring gene COP9 signalosome subunit 6 Neighboring gene microRNA 25 Neighboring gene minichromosome maintenance complex component 7

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ20216

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor activity, sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
leukocyte activation NAS
Non-traceable Author Statement
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IC
Inferred by Curator
more info
PubMed 
Preferred Names
zinc finger protein 3
Names
C2-H2 type zinc finger protein
zinc finger protein HF.12
zinc finger protein HZF3.1
zinc finger protein KOX25

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278284.1NP_001265213.1  zinc finger protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001265213.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes isoform 2. Variants 2, 3, 4, 5, and 8 all encode the same isoform (2).
    Source sequence(s)
    BC041695, CA439866
    Consensus CDS
    CCDS43619.1
    UniProtKB/Swiss-Prot
    P17036
    Conserved Domains (5) summary
    cd07765
    Location:5190
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:5196
    KRAB; krueppel associated box
    COG5048
    Location:175353
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:214239
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001278287.1NP_001265216.1  zinc finger protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001265216.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 2, 3, 4, 5, and 8 all encode the same isoform (2).
    Source sequence(s)
    BC041695, BQ071498, CA439866
    Consensus CDS
    CCDS43619.1
    UniProtKB/Swiss-Prot
    P17036
    Conserved Domains (5) summary
    cd07765
    Location:5190
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:5196
    KRAB; krueppel associated box
    COG5048
    Location:175353
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:214239
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001278290.1NP_001265219.1  zinc finger protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001265219.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. Variants 2, 3, 4, 5, and 8 all encode the same isoform (2).
    Source sequence(s)
    BC041695, CA439866, DC384519, HY096067
    Consensus CDS
    CCDS43619.1
    UniProtKB/Swiss-Prot
    P17036
    Related
    ENSP00000415358, ENST00000424697
    Conserved Domains (5) summary
    cd07765
    Location:5190
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:5196
    KRAB; krueppel associated box
    COG5048
    Location:175353
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:214239
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001278291.1NP_001265220.1  zinc finger protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001265220.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks the exon containing the translation start site, and initiates translation at an alternate start codon compared to variant 3. The resulting isoform (3) is shorter at the N-terminus compared to isoform 2. Variants 6 and 7 both encode the same isoform (3).
    Source sequence(s)
    BC041695, CA439866, DA443888, DC384519
    UniProtKB/TrEMBL
    Q86U76
    Conserved Domains (5) summary
    cd07765
    Location:1554
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:1560
    KRAB; krueppel associated box
    COG5048
    Location:139317
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:178203
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:250270
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001278292.1NP_001265221.1  zinc finger protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001265221.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks the exon containing the translation start site and initiates translation at an alternate start codon compared to variant 3. The resulting isoform (3) is shorter at the N-terminus compared to isoform 2. Variants 6 and 7 both encode the same isoform (3).
    Source sequence(s)
    BC041695, CA439866, DA623743, DC384519
    UniProtKB/TrEMBL
    Q86U76
    Conserved Domains (5) summary
    cd07765
    Location:1554
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:1560
    KRAB; krueppel associated box
    COG5048
    Location:139317
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:178203
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:250270
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_001318135.1NP_001305064.1  zinc finger protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 3. Variants 2, 3, 4, 5, and 8 all encode the same isoform (2).
    Source sequence(s)
    BC011887, BC025265, CA439866, DC347416
    UniProtKB/Swiss-Prot
    P17036
    Conserved Domains (5) summary
    cd07765
    Location:5190
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:5196
    KRAB; krueppel associated box
    COG5048
    Location:175353
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:214239
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. NM_001318136.1NP_001305065.1  zinc finger protein 3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks two exons in its 5' UTR, contains an alternate internal segment, and uses an alternate start codon, compared to variant 3. The encoded isoform (4) has a longer and distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    AK091984, BC013603, CA439866, CB988353, DC347416
    UniProtKB/Swiss-Prot
    P17036
    UniProtKB/TrEMBL
    B3KRP4
    Conserved Domains (5) summary
    cd07765
    Location:5897
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:58103
    KRAB; krueppel associated box
    COG5048
    Location:182360
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:221246
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:293313
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. NM_001318137.1NP_001305066.1  zinc finger protein 3 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) has multiple differences in the UTRs and coding region, one of which results in the use of a downstream in-frame start codon, compared to variant 3. The resulting isoform (5) has a shorter N-terminus and a distinct C-terminus compared to isoform 2.
    Source sequence(s)
    AF193057, AK000223, BC011887, CB129643, DC347416
    UniProtKB/Swiss-Prot
    P17036
    Conserved Domains (2) summary
    cd07765
    Location:1554
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:1555
    KRAB; krueppel associated box
  9. NM_017715.3NP_060185.2  zinc finger protein 3 isoform 1

    See identical proteins and their annotated locations for NP_060185.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 3. The resulting isoform (1) has a shorter and distinct C-terminus compared to isoform 2.
    Source sequence(s)
    AF217988, AK000223, DC384519
    Consensus CDS
    CCDS43618.1
    UniProtKB/Swiss-Prot
    P17036
    Related
    ENSP00000399951, OTTHUMP00000214592, ENST00000413658, OTTHUMT00000354216
    Conserved Domains (2) summary
    cd07765
    Location:5190
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:5191
    KRAB; krueppel associated box
  10. NM_032924.4NP_116313.3  zinc finger protein 3 isoform 2

    See identical proteins and their annotated locations for NP_116313.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 2, 3, 4, 5, and 8 all encode the same isoform (2).
    Source sequence(s)
    BC013603, CA439866, DC384519
    Consensus CDS
    CCDS43619.1
    UniProtKB/Swiss-Prot
    P17036
    Related
    ENSP00000299667, OTTHUMP00000206232, ENST00000299667, OTTHUMT00000336247
    Conserved Domains (5) summary
    cd07765
    Location:5190
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:5196
    KRAB; krueppel associated box
    COG5048
    Location:175353
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:214239
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    100063847..100082548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716110.2XP_006716173.1  

    Conserved Domains (5) summary
    cd07765
    Location:5897
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:58103
    KRAB; krueppel associated box
    COG5048
    Location:182360
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:221246
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:293313
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_006716111.1XP_006716174.1  

    See identical proteins and their annotated locations for XP_006716174.1

    UniProtKB/TrEMBL
    Q86U76
    Conserved Domains (5) summary
    cd07765
    Location:1554
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:1560
    KRAB; krueppel associated box
    COG5048
    Location:139317
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:178203
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:250270
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    99591633..99610334 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)