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ZFX zinc finger protein, X-linked [ Homo sapiens (human) ]

Gene ID: 7543, updated on 8-May-2016
Official Symbol
ZFXprovided by HGNC
Official Full Name
zinc finger protein, X-linkedprovided by HGNC
Primary source
HGNC:HGNC:12869
See related
Ensembl:ENSG00000005889 HPRD:02445; MIM:314980; Vega:OTTHUMG00000021264
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF926
Summary
This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]
Orthologs
Location:
Xp21.3
Exon count:
17
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (24148934..24216255)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (24167047..24234372)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene kelch like family member 15 Neighboring gene eukaryotic translation initiation factor 2 subunit gamma Neighboring gene ZFX antisense RNA 1 Neighboring gene SPT20 homolog, SAGA complex component-like 2 Neighboring gene SPT20 homolog, SAGA complex component-like 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
transcription factor activity, sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
zinc finger X-chromosomal protein
Names
X-linked zinc finger protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021253.1 RefSeqGene

    Range
    4909..71519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178084.1NP_001171555.1  zinc finger X-chromosomal protein isoform 1

    See identical proteins and their annotated locations for NP_001171555.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two exons in the 5' UTR, as compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AB209892, AC002404, DA995443, X59739
    Consensus CDS
    CCDS14211.1
    UniProtKB/Swiss-Prot
    P17010
    UniProtKB/TrEMBL
    A0A024RC04, Q59EB9
    Related
    ENSP00000343384, OTTHUMP00000023080, ENST00000338565, OTTHUMT00000056086
    Conserved Domains (5) summary
    pfam04704
    Location:69410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    COG5048
    Location:543805
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:562584
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:427447
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
    sd00017
    Location:490510
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001178085.1NP_001171556.1  zinc finger X-chromosomal protein isoform 1

    See identical proteins and their annotated locations for NP_001171556.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an additional exon in the 5' UTR, as compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AB209892, AC002404, M30608, X59740
    Consensus CDS
    CCDS14211.1
    UniProtKB/Swiss-Prot
    P17010
    UniProtKB/TrEMBL
    A0A024RC04, Q59EB9
    Related
    ENSP00000368475, OTTHUMP00000023078, ENST00000379177, OTTHUMT00000056084
    Conserved Domains (5) summary
    pfam04704
    Location:69410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    COG5048
    Location:543805
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:562584
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:427447
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
    sd00017
    Location:490510
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001178086.1NP_001171557.1  zinc finger X-chromosomal protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks several exons in the 5' region, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AB209892, AC002404, X59738
    Consensus CDS
    CCDS55390.1
    UniProtKB/Swiss-Prot
    P17010
    UniProtKB/TrEMBL
    Q59EB9
    Related
    ENSP00000438233, ENST00000539115
    Conserved Domains (5) summary
    pfam04704
    Location:1181
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    COG5048
    Location:314438
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:333355
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:198218
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
    sd00017
    Location:261281
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001178095.1NP_001171566.1  zinc finger X-chromosomal protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two exons in the 5' UTR and has an additional segment in the 3' CDS, as compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AB209892, AC002404
    UniProtKB/TrEMBL
    Q59EB9
    Conserved Domains (1) summary
    pfam04704
    Location:69410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
  5. NM_003410.3NP_003401.2  zinc finger X-chromosomal protein isoform 1

    See identical proteins and their annotated locations for NP_003401.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variants 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC002404, AF454950, DA848249, M30608
    Consensus CDS
    CCDS14211.1
    UniProtKB/Swiss-Prot
    P17010
    UniProtKB/TrEMBL
    A0A024RC04, Q8WXB7
    Related
    ENSP00000304985, OTTHUMP00000023079, ENST00000304543, OTTHUMT00000056085
    Conserved Domains (5) summary
    pfam04704
    Location:69410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    COG5048
    Location:543805
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:562584
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:427447
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
    sd00017
    Location:490510
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    24148934..24216255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274592.2XP_005274649.1  

    See identical proteins and their annotated locations for XP_005274649.1

    UniProtKB/Swiss-Prot
    P17010
    UniProtKB/TrEMBL
    A0A024RC04
    Conserved Domains (5) summary
    pfam04704
    Location:69410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    COG5048
    Location:543805
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:562584
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:427447
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
    sd00017
    Location:490510
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_011545578.1XP_011543880.1  

    See identical proteins and their annotated locations for XP_011543880.1

    UniProtKB/Swiss-Prot
    P17010
    Conserved Domains (5) summary
    pfam04704
    Location:108449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    COG5048
    Location:582719
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:601623
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:466486
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
    sd00017
    Location:529549
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_011545577.1XP_011543879.1  

    See identical proteins and their annotated locations for XP_011543879.1

    UniProtKB/Swiss-Prot
    P17010
    Conserved Domains (5) summary
    pfam04704
    Location:108449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    COG5048
    Location:582719
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:601623
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:466486
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
    sd00017
    Location:529549
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_011545581.1XP_011543883.1  

    See identical proteins and their annotated locations for XP_011543883.1

    UniProtKB/Swiss-Prot
    P17010
    UniProtKB/TrEMBL
    A0A024RC04
    Conserved Domains (5) summary
    pfam04704
    Location:69410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    COG5048
    Location:543805
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:562584
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:427447
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
    sd00017
    Location:490510
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_006724515.2XP_006724578.1  

    Conserved Domains (5) summary
    pfam04704
    Location:108396
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    COG5048
    Location:535672
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:554576
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:419439
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
    sd00017
    Location:482502
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_006724513.2XP_006724576.1  

    See identical proteins and their annotated locations for XP_006724576.1

    UniProtKB/Swiss-Prot
    P17010
    Related
    ENSP00000368486, ENST00000379188
    Conserved Domains (5) summary
    pfam04704
    Location:108449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    COG5048
    Location:582719
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:601623
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:466486
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
    sd00017
    Location:529549
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. XM_005274591.3XP_005274648.1  

    See identical proteins and their annotated locations for XP_005274648.1

    UniProtKB/Swiss-Prot
    P17010
    UniProtKB/TrEMBL
    A0A024RC04
    Conserved Domains (5) summary
    pfam04704
    Location:69410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    COG5048
    Location:543805
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:562584
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:427447
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
    sd00017
    Location:490510
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. XM_011545580.1XP_011543882.1  

    See identical proteins and their annotated locations for XP_011543882.1

    UniProtKB/Swiss-Prot
    P17010
    UniProtKB/TrEMBL
    A0A024RC04
    Conserved Domains (5) summary
    pfam04704
    Location:69410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    COG5048
    Location:543805
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:562584
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:427447
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
    sd00017
    Location:490510
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. XM_011545579.1XP_011543881.1  

    See identical proteins and their annotated locations for XP_011543881.1

    UniProtKB/Swiss-Prot
    P17010
    UniProtKB/TrEMBL
    A0A024RC04
    Conserved Domains (5) summary
    pfam04704
    Location:69410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    COG5048
    Location:543805
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:562584
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:427447
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
    sd00017
    Location:490510
    ZF_C2H2; C2H2 Zn finger [structural motif]
  10. XM_011545582.1XP_011543884.1  

    See identical proteins and their annotated locations for XP_011543884.1

    Conserved Domains (5) summary
    pfam04704
    Location:44385
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    COG5048
    Location:518655
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:537559
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:402422
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
    sd00017
    Location:465485
    ZF_C2H2; C2H2 Zn finger [structural motif]
  11. XM_011545583.1XP_011543885.1  

    See identical proteins and their annotated locations for XP_011543885.1

    Conserved Domains (5) summary
    pfam04704
    Location:44385
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    COG5048
    Location:518655
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:537559
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:402422
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
    sd00017
    Location:465485
    ZF_C2H2; C2H2 Zn finger [structural motif]
  12. XM_005274594.3XP_005274651.1  

    See identical proteins and their annotated locations for XP_005274651.1

    Conserved Domains (5) summary
    pfam04704
    Location:44385
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    COG5048
    Location:518655
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:537559
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:402422
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
    sd00017
    Location:465485
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    24199109..24265719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)