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    YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide [ Homo sapiens ]

    Gene ID: 7534, updated on 5-Feb-2012
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    Summary

    Official Symbol
    YWHAZprovided by HGNC
    Official Full Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptideprovided by HGNC
    Primary source
    HGNC:12855
    See related
    Ensembl:ENSG00000164924; HPRD:03183; MIM:601288; Vega:OTTHUMG00000134291
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    YWHAD; KCIP-1; 14-3-3-zeta
    Summary
    This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
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    Genomic context

    Location :
    8q23.1
    Sequence :
    Chromosome: 8; NC_000008.10 (101930804..101965623, complement)
    See YWHAZ in Epigenomics, MapViewer

    Chromosome 8 - NC_000008.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S20 pseudogene 23 Neighboring gene ribosomal protein S26 pseudogene 6 Neighboring gene uncharacterized LOC441374 Neighboring gene zinc finger protein 706

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. 14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. Andersen SD, et al. DNA Repair (Amst), 2012 Mar 1. PMID 22222486.
    2. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). Lopitz-Otsoa F, et al. J Proteomics, 2011 Dec 10. PMID 22178446.
    3. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    4. Properties of the monomeric form of human 14-3-3ζ protein and its interaction with tau and HspB6. Sluchanko NN, et al. Biochemistry, 2011 Nov 15. PMID 21978388.
    5. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Li S, et al. Immunity, 2011 Sep 23. PMID 21903422.

    See all (232) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Properties of the monomeric form of 14-3-3zeta protein and its interaction with tau and HspB6. This interaction requires phosphorylation of tau protein and HspB6.
      Title: Properties of the monomeric form of human 14-3-3ζ protein and its interaction with tau and HspB6.
    2. 14-3-3zeta is a key predictive marker for risk of failure on endocrine therapy and serves a pivotal role impacting growth factor signaling, and promoting cell survival and resistance to endocrine therapies.
      Title: Reversal of endocrine resistance in breast cancer: interrelationships among 14-3-3ζ, FOXM1, and a gene signature associated with mitosis.
    3. These findings suggest a previously unrecognized mechanism of integrin-induced Rac1 activation in which 14-3-3 dimers localize Tiam1 to integrin complexes, where it mediates integrin-dependent Rac1 activation, thus initiating motility-inducing pathways.
      Title: Tiam1 is recruited to β1-integrin complexes by 14-3-3ζ where it mediates integrin-induced Rac1 activation and motility.
    4. NMR spectroscopy revealed the presence of a flexible and unstructured C-terminal extension, 12 amino acids in length, which protrudes from the domain core of 14-3-3zeta and is similar in to the C-terminal extension of heat shock proteins.
      Title: NMR spectroscopy of 14-3-3ζ reveals a flexible C-terminal extension: differentiation of the chaperone and phosphoserine-binding activities of 14-3-3ζ.
    5. data support a model where both AKT and 14-3-3 zeta positively regulate FoxO3 in addition to their established negative roles and that 14-3-3 zeta availability could dictate the fate of phosphorylated FoxO3 toward degradation or recycling
      Title: Bimodal regulation of FoxO3 by AKT and 14-3-3.
    6. 14-3-3zeta proteins are shown as a negative regulator of autophagy through regulation of a key component of early stages of the autophagy pathway, such as hVps34.
      Title: Regulation of autophagic activity by 14-3-3ζ proteins associated with class III phosphatidylinositol-3-kinase.
    7. Data show that the expression of 14-3-3 zeta was associated with the degree of cancer peritoneal metastasis.
      Title: LC-MS/MS analysis of ovarian cancer metastasis-related proteins using a nude mouse model: 14-3-3 zeta as a candidate biomarker.
    8. 14-3-3zeta silencing in hepatocellular carcinoma inhibits tumor growth and enhances chemosensitivity to cis-diammined dichloridoplatium
      Title: Silencing of 14-3-3ζ over-expression in hepatocellular carcinoma inhibits tumor growth and enhances chemosensitivity to cis-diammined dichloridoplatium.
    9. Guggulsterone targets 14-3-3 zeta associated cellular pathways for reducing proliferation and inducing apoptosis in head and neck cancer cells.
      Title: 14-3-3 zeta is a molecular target in guggulsterone induced apoptosis in head and neck cancer cells.
    10. The 14-3-3 zeta mutation mimicking phosphorylation of Ser184 does not markedly affect interaction with tau protein and improves the interaction of 14-3-3 zeta with HspB6.
      Title: Phosphomimicking mutations of human 14-3-3ζ affect its interaction with tau protein and small heat shock protein HspB6.
    Submit: New GeneRIF Correction See all (62)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr Interaction of HIV-1 Vpr with human 14-3-3 protein is presumed based on homology to yeast DNA damage checkpoint protein rad25 which enhances HIV-1 Vpr-induced G2 arrest in vitro, most likely through the inhibition of Cdc25 PubMed
    vpr HIV-1 Vpr inhibits insulin-induced association of 14-3-3 and Foxo3a in HeLa cells PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_003397.1 NP_001079.1 AANAT    BIND  PubMed AANAT interacts with 14-3-3-zeta isoform. This interaction was modeled on a demonstrated interaction between sheep AANAT and human 14-3-3-zeta. 
    NP_003397.1 NP_005154.1 AKT1    BIND  PubMed Akt interaction with and phosphorylation of 14-3-3 zeta at the same residue as MAPKAPK2. 
    NP_003397.1 NP_005179.2 CBL    BIND  PubMed c-Cbl interacts with 14-3-3-zeta. 
    NP_003397.1 P30305 CDC25B    BIND  PubMed 14-3-3-zeta interacts with phosphorylated CDC25B. 
    NP_003397.1 NP_751919.1 HCVgp1    BIND  PubMed HCV core interacts with 14-3-3 zeta. This interaction was modeled on a demonstrated interaction between HCV core protein and yeast Bmh1(14-3-3). 
    NP_003397.1 NP_000866.1 IGF1R    BIND  PubMed IGFIR interacts with 14-3-3-zeta isoform. 
    NP_003397.1 NP_116584.2 MAPKAPK2    BIND  PubMed MAPKAPK2 interacts with and phosphorylates 14-3-3-zeta. 
    NP_003397.1 NP_058519.1 MAPT    BIND  PubMed Tau interacts with 14-3-3-zeta. 
    NP_003397.1 NP_002871.1 RAF1    BIND  PubMed Raf-1 interacts with 14-3-3 zeta. This interaction was modelled on a demonstrated interaction between human Raf-1 and murine 14-3-3-zeta. 
    NP_003397.1 BAB84115.1 SSH1    BIND  PubMed SSH-1S interacts with 14-3-3-zeta. 
    NP_003397.1 NP_061857.2 SSH1    BIND  PubMed SSH-1L interacts with 14-3-3-zeta. 
    NP_003397.1 SSH2    BIND  PubMed SSH-2S interacts with 14-3-3-zeta. 
    NP_003397.1 NP_060746.2 SSH3    BIND  PubMed SSH-3S interacts with 14-3-3-zeta. 
    NP_003397.1 NP_000539.1 TSC2    BIND  PubMed Tumor suppressor protein tuberin interacts with 14-3-3-zeta isoform. 
    NP_003397.1 NP_003346.2 UCP2    BIND  PubMed UCP2 interacts with 14.3.3-zeta. 
    NP_003397.1 NP_003347.1 UCP3    BIND  PubMed UCP3 interacts with 14.3.3-zeta. 
    NP_003397.1 NP_003397.1 YWHAZ    BIND  PubMed 14-3-3zeta homodimerizes. 
    NP_663723.1 NP_005154.1 AKT1    BIND  PubMed Akt interaction with and phosphorylation of 14-3-3 zeta at the same residue as MAPKAPK2. 
    NP_663723.1 EGFR    BIND  PubMed EGFR interacts with 14-3-3-zeta. 
    NP_663723.1 NP_116584.2 MAPKAPK2    BIND  PubMed MAPKAPK2 interacts with and phosphorylates 14-3-3-zeta. 
    NP_663723.1 NP_663723.1 YWHAZ    BIND  PubMed 14-3-3zeta homodimerizes. 
    P63104 Q16613 AANAT    HPRD  PubMed  
    P63104 P00519 ABL1    HPRD  PubMed  
    P63104 Q9P0K1 ADAM22    HPRD  PubMed  
    P63104 P08913 ADRA2A    HPRD  PubMed  
    P63104 P18089 ADRA2B    HPRD  PubMed  
    P63104 P18825 ADRA2C    HPRD  PubMed  
    P63104 Q12802 AKAP13    HPRD  PubMed  
    P63104 P31749 AKT1    HPRD  PubMed  
    P63104 Q92974 ARHGEF2    HPRD  PubMed  
    P63104 P25705 ATP5A1    HPRD  PubMed  
    P63104 P54253 ATXN1    HPRD  PubMed  
    P63104 Q92934 BAD    HPRD  PubMed  
    P63104 P56945 BCAR1    HPRD  PubMed  
    P63104 P11274 BCR    HPRD  PubMed  
    P63104 P15056 BRAF    HPRD  PubMed  
    P63104 Q5W0U4 BSPRY    HPRD  PubMed  
    P63104 P22681 CBL    HPRD  PubMed  
    P63104 P30304 CDC25A    HPRD  PubMed  
    P63104 P30305 CDC25B    HPRD  PubMed  
    P63104 P30307 CDC25C    HPRD  PubMed  
    P63104 Q00536 CDK16    HPRD  PubMed  
    P63104 Q00537 CDK17    HPRD  PubMed  
    P63104 Q9HC77 CENPJ    HPRD  PubMed  
    P63104 P23528 CFL1    HPRD  PubMed  
    P63104 Q9Y696 CLIC4    HPRD  PubMed  
    P63104 Transducer of regulated cAMP response element binding protein 2 CRTC2    HPRD  PubMed  
    P63104 P32927 CSF2RB    HPRD  PubMed  
    P63104 P48729 CSNK1A1    HPRD  PubMed  
    P63104 O00273 DFFA    HPRD  PubMed  
    P63104 P00533 EGFR    HPRD  PubMed  
    P63104 P06733 ENO1    HPRD  PubMed  
    P63104 Q9H4G0 EPB41L1    HPRD  PubMed  
    P63104 Q9Y2J2 EPB41L3    HPRD  PubMed  
    P63104 Q12778 FOXO1    HPRD  PubMed  
    P63104 O43524 FOXO3    HPRD  PubMed  
    P63104 P98177 FOXO4    HPRD  PubMed  
    P63104 Q9UBS5 GABBR1    HPRD  PubMed  
    P63104 P07359 GP1BA    HPRD  PubMed  
    P63104 P13224 GP1BB    HPRD  PubMed  
    P63104 P40197 GP5    HPRD  PubMed  
    P63104 P56524 HDAC4    HPRD  PubMed  
    P63104 P05114 HMGN1    HPRD  PubMed  
    P63104 Heat shock 70 KD protein 1A HSPA1A    HPRD  PubMed  
    P63104 P08107 HSPA1B    HPRD  PubMed  
    P63104 P08069 IGF1R    HPRD  PubMed  
    P63104 Q01113 IL9R    HPRD  PubMed  
    P63104 Q9UK53 ING1    HPRD  PubMed  
    P63104 Q14642 INPP5A    HPRD  PubMed  
    P63104 P35568 IRS1    HPRD  PubMed  
    P63104 Q9Y4H2 IRS2    HPRD  PubMed  
    P63104 Q9H427 KCNK15    HPRD  PubMed  
    P63104 O14649 KCNK3    HPRD  PubMed  
    P63104 Q9NPC2 KCNK9    HPRD  PubMed  
    P63104 Q6ICG6 KIAA0930    HPRD  PubMed  
    P63104 Q9P2H0 KIAA1377    HPRD  PubMed  
    P63104 O43896 KIF1C    HPRD  PubMed  
    P63104 P33176 KIF5B    HPRD  PubMed  
    P63104 Q9H0B6 KLC2    HPRD  PubMed  
    P63104 Q9NSK0 KLC4    HPRD  PubMed  
    P63104 P05783 KRT18    HPRD  PubMed  
    P63104 Q8IVT5 KSR1    HPRD  PubMed  
    P63104 Q6PKG0 LARP1    HPRD  PubMed  
    P63104 P53667 LIMK1    HPRD  PubMed  
    P63104 Q9Y2U5 MAP3K2    HPRD  PubMed  
    P63104 Q99759 MAP3K3    HPRD  PubMed  
    P63104 Q99683 MAP3K5    HPRD  PubMed  
    P63104 P45983 MAPK8    HPRD  PubMed  
    P63104 P49137 MAPKAPK2    HPRD  PubMed  
    P63104 P10636 MAPT    HPRD  PubMed  
    P63104 Q7KZI7 MARK2    HPRD  PubMed  
    P63104 P27448 MARK3    HPRD  PubMed  
    P63104 Q96L34 MARK4    HPRD  PubMed  
    P63104 O15151 MDM4    HPRD  PubMed  
    P63104 Q8N4C8 MINK1    HPRD  PubMed  
    P63104 P58340 MLF1    HPRD  PubMed  
    P63104 Q04912 MST1R    HPRD  PubMed  
    P63104 Q13469 NFATC2    HPRD  PubMed  
    P63104 Q14934 NFATC4    HPRD  PubMed  
    P63104 P22736 NR4A1    HPRD  PubMed  
    P63104 O96013 PAK4    HPRD  PubMed  
    P63104 Q8TEW0 PARD3    HPRD  PubMed  
    P63104 Q9NPB6 PARD6A    HPRD  PubMed  
    P63104 Q9BYG5 PARD6B    HPRD  PubMed  
    P63104 P20941 PDC    HPRD  PubMed  
    P63104 O60825 PFKFB2    HPRD  PubMed  
    P63104 P36873 PPP1CC    HPRD  PubMed  
    P63104 P17252 PRKCA    HPRD  PubMed  
    P63104 Q05655 PRKCD    HPRD  PubMed  
    P63104 P41743 PRKCI    HPRD  PubMed  
    P63104 P16471 PRLR    HPRD  PubMed  
    P63104 Q12923 PTPN13    HPRD  PubMed  
    P63104 P04049 RAF1    HPRD  PubMed  
    P63104 Ral GEF with PH domain and SH3 binding motif 2 RALGPS2    HPRD  PubMed  
    P63104 O75628 REM1    HPRD  PubMed  
    P63104 P49796 RGS3    HPRD  PubMed  
    P63104 Q13671 RIN1    HPRD  PubMed  
    P63104 P55042 RRAD    HPRD  PubMed  
    P63104 P57059 SIK1    HPRD  PubMed  
    P63104 KIAA0999 protein SIK3    HPRD  PubMed  
    P63104 Q9UPR5 SLC8A2    HPRD  PubMed  
    P63104 O00506 STK25    HPRD  PubMed  
    P63104 Q15208 STK38    HPRD  PubMed  
    P63104 P21731 TBXA2R    HPRD  PubMed  
    P63104 P07101 TH    HPRD  PubMed  
    P63104 Q9UDY2 TJP2    HPRD  PubMed  
    P63104 Q86UE8 TLK2    HPRD  PubMed  
    P63104 P21580 TNFAIP3    HPRD  PubMed  
    P63104 P04637 TP53    HPRD  PubMed  
    P63104 Q16890 TPD52L1    HPRD  PubMed  
    P63104 P17752 TPH1    HPRD  PubMed  
    P63104 P62995 TRA2B    HPRD  PubMed  
    P63104 P19474 TRIM21    HPRD  PubMed  
    P63104 Q92574 TSC1    HPRD  PubMed  
    P63104 P49815 TSC2    HPRD  PubMed  
    P63104 P07437 TUBB    HPRD  PubMed  
    P63104 P62988 UBB    HPRD  PubMed  
    P63104 P55851 UCP2    HPRD  PubMed  
    P63104 P55916 UCP3    HPRD  PubMed  
    P63104 P08670 VIM    HPRD  PubMed  
    P63104 P30291 WEE1    HPRD  PubMed  
    P63104 P12956 XRCC6    HPRD  PubMed  
    P63104 P62258 YWHAE    HPRD  PubMed  
    P63104 P63104 YWHAZ    HPRD  PubMed  
    BioGRID:113366 BioGRID:106533 AANAT    BioGRID  PubMed Co-crystal Structure; Co-purification 
    NP_005148.1 ABL1    BIND  PubMed c-Abl interacts with 14-3-3-delta. 
    BioGRID:113366 BioGRID:106650 ADORA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:106710 AKT1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113366 BioGRID:106864 ARAF    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:106987 ATP5A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:107048 BAD    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113366 BioGRID:114934 BCAR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113366 BioGRID:107141 BRAF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:117036 BRD4    BioGRID  PubMed Co-localization 
    BioGRID:113366 BioGRID:131981 C5orf25    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:107315 CBL    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:107428 CDC25A    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:107429 CDC25B    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113366 BioGRID:107424 CDC5L    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:111154 CDK16    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:107461 CDKN1B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113366 BioGRID:120939 CENPJ    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:124384 CGNL1    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:115349 CHAF1A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Two-hybrid 
    BioGRID:113366 BioGRID:116183 COPS5    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:107826 CSF2RB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113366 BioGRID:116800 CYFIP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:117945 CYFIP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:115532 DCAF7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:108040 DFFA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:118061 DISC1    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:124527 DOCK7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:123144 EDC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:108276 EGFR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:114210 EIF3A    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:108338 ENO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:108351 EPB41L2    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:116753 EPB41L3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:114602 EXO1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113366 BioGRID:119457 FAM13B    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:119458 FAM53C    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:115098 FAM65B    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:120476 FAM82A2    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:116573 FAN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:118877 FHOD1    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:108597 FOXO1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113366 BioGRID:108598 FOXO3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113366 BioGRID:116473 GABARAPL2    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:109073 GP1BA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113366 BioGRID:109074 GP1BB    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113366 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113366 BioGRID:115106 HDAC4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113366 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:119613 HDAC7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113366 BioGRID:115083 HDAC9    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:113946 HIST1H3A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex 
    BioGRID:113366 BioGRID:113955 HIST1H4A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113366 BioGRID:109344 HIVEP2    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:109393 HMGN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113366 BioGRID:109432 HNRNPL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:35980 HRR25    BioGRID  PubMed Biochemical Activity 
    BioGRID:113366 BioGRID:109536 HSPA1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:109795 IL9R    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113366 BioGRID:109833 ING1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113366 BioGRID:109844 INPP5A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113366 BioGRID:123914 KAT8    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:113366 BioGRID:115122 KIAA0232    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:116904 KIAA0930    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:121617 KIAA1377    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:114873 KIF23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:110000 KIF5B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:110029 KLC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:124648 KLC4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:116947 LARP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:110129 LCP2    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:110172 LIMK1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113366 BioGRID:110213 LRMP    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:107552 LYST    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113366 BioGRID:114136 MADD    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:111593 MAP2K5    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:110380 MAP3K4    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:110381 MAP3K5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113366 BioGRID:110308 MAPT    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113366 BioGRID:110309 MARK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:108326 MARK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:110310 MARK3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113366 BioGRID:110372 MEF2C    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:121122 MEPCE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:110411 MGMT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:115493 MPHOSPH9    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:120467 MSL2    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:110712 MYH9    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:204968 Mapk13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:208443 Mlxipl    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:122408 NADK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:116003 NCKAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:116915 NEDD4L    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:110849 NFATC4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113366 BioGRID:114654 NOLC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:115436 OPTN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:114296 PABPC4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:111095 PAK1    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:115586 PAK4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:121134 PARD3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113366 BioGRID:119157 PARD6A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:114667 PNMA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:115926 PNMA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:111549 PRKAA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:111564 PRKCA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113366 BioGRID:111566 PRKCD    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113366 BioGRID:111567 PRKCE    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113366 BioGRID:111570 PRKCI    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113366 BioGRID:111576 PRKCZ    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:113366 BioGRID:111573 PRKD1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113366 BioGRID:111764 PTPRO    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:111831 RAF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113366 BioGRID:117526 RAI14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:120413 RALGPS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:116732 RAP1GAP2    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:122348 RASAL3    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:118781 REM1    BioGRID  PubMed Affinity Capture-Western; Far Western; Reconstituted Complex 
    BioGRID:113366 BioGRID:122136 RFWD2    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:113366 BioGRID:111930 RGS3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113366 BioGRID:112079 RPL31    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:112150 RRAD    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113366 BioGRID:120407 SAMD4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:122054 SAMSN1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113366 BioGRID:117017 SF3B1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:112352 SH3GL1    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:127260 SIK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113366 BioGRID:116963 SIK3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113366 BioGRID:125635 SNRPD2P1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:118791 SNX24    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:112622 SSFA2    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:116457 STK38    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:112720 SYN2    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:116474 SYNPO    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:128105 SYNPO2    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:112786 TCEB3    BioGRID  PubMed Co-localization 
    BioGRID:113366 BioGRID:112874 TERT    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:114809 TJP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:112983 TNFAIP3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113366 BioGRID:112999 TNS1    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113366 BioGRID:113019 TPH1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113366 BioGRID:112332 TRA2B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:112615 TRIM21    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:113099 TSC1    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:113100 TSC2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113366 BioGRID:113129 TUBA3C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:128444 TUBB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:113134 TUBG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:113185 UBE3A    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:119509 UCHL5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113366 BioGRID:113198 UCP2    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:113199 UCP3    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:114555 USP8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:220000 Usp8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:113272 VIM    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113366 BioGRID:122403 WNK1    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:122423 WNK2    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:117434 WWTR1    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:108822 XRCC6    BioGRID  PubMed Two-hybrid 
    BioGRID:113366 BioGRID:113363 YWHAE    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113366 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113366 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113366 BioGRID:120893 ZNF839    BioGRID  PubMed Two-hybrid 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Clone Names

    • MGC111427, MGC126532, MGC138156

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    RNA metabolic process TAS
    Traceable Author Statement
    more info
    		  
    anti-apoptosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    histamine secretion by mast cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    mRNA metabolic process TAS
    Traceable Author Statement
    more info
    		  
    platelet activation TAS
    Traceable Author Statement
    more info
    		  
    protein targeting to mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to drug IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cell leading edge IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    melanosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    soluble fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    14-3-3 protein zeta/delta
    Names
    14-3-3 protein zeta/delta
    14-3-3 zeta
    14-3-3 delta
    phospholipase A2
    protein kinase C inhibitor protein 1
    protein kinase C inhibitor protein-1
    14-3-3 protein/cytosolic phospholipase A2
    tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135699.1 → NP_001129171.1  14-3-3 protein zeta/delta

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. All six transcripts encode the same protein.
      Source sequence(s)
      AA830489, BC072426, BM783874
      Consensus CDS
      CCDS6290.1
      UniProtKB/TrEMBL
      D0PNI1
      UniProtKB/Swiss-Prot
      P63104
      Related
      ENSP00000398599, ENST00000457309
      Conserved Domains (1) summary
      cd10022
      Location:2 – 230
      Blast Score: 1051
      14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

    2. NM_001135700.1 → NP_001129172.1  14-3-3 protein zeta/delta

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. All six transcripts encode the same protein.
      Source sequence(s)
      BC072426, BM783874, CR996247
      Consensus CDS
      CCDS6290.1
      UniProtKB/TrEMBL
      D0PNI1
      UniProtKB/Swiss-Prot
      P63104
      Related
      ENSP00000379286, OTTHUMP00000165854, ENST00000395956, OTTHUMT00000259020
      Conserved Domains (1) summary
      cd10022
      Location:2 – 230
      Blast Score: 1051
      14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

    3. NM_001135701.1 → NP_001129173.1  14-3-3 protein zeta/delta

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 2. All six transcripts encode the same protein.
      Source sequence(s)
      BC072426, BM783874, CN276627, CR996247
      Consensus CDS
      CCDS6290.1
      UniProtKB/TrEMBL
      D0PNI1
      UniProtKB/Swiss-Prot
      P63104
      Related
      ENSP00000395114, OTTHUMP00000165859, ENST00000419477, OTTHUMT00000259026
      Conserved Domains (1) summary
      cd10022
      Location:2 – 230
      Blast Score: 1051
      14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

    4. NM_001135702.1 → NP_001129174.1  14-3-3 protein zeta/delta

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 2. All six transcripts encode the same protein.
      Source sequence(s)
      BC072426, BM783874, BQ605329, DB472116
      Consensus CDS
      CCDS6290.1
      UniProtKB/TrEMBL
      D0PNI1
      UniProtKB/Swiss-Prot
      P63104
      Related
      ENSP00000379281, OTTHUMP00000165860, ENST00000395951, OTTHUMT00000259027
      Conserved Domains (1) summary
      cd10022
      Location:2 – 230
      Blast Score: 1051
      14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

    5. NM_003406.3 → NP_003397.1  14-3-3 protein zeta/delta

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. All six transcripts encode the same protein.
      Source sequence(s)
      BC072426, BM783874, DC298291
      Consensus CDS
      CCDS6290.1
      UniProtKB/TrEMBL
      D0PNI1
      UniProtKB/Swiss-Prot
      P63104
      Related
      ENSP00000309503, OTTHUMP00000165852, ENST00000353245, OTTHUMT00000259018
      Conserved Domains (1) summary
      cd10022
      Location:2 – 230
      Blast Score: 1051
      14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

    6. NM_145690.2 → NP_663723.1  14-3-3 protein zeta/delta

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. All six transcripts encode the same protein.
      Source sequence(s)
      BC072426, BM783874, CN276619
      Consensus CDS
      CCDS6290.1
      UniProtKB/TrEMBL
      D0PNI1
      UniProtKB/Swiss-Prot
      P63104
      Related
      ENSP00000379288, ENST00000395958
      Conserved Domains (1) summary
      cd10022
      Location:2 – 230
      Blast Score: 1051
      14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000008.10 Reference GRCh37.p5 Primary Assembly

      Range
      101930804..101965623, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000140.1 Alternate HuRef

      Range
      97128746..97163575, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC018781.9 (161040..186054) None
    genomic AC027373.11 None
    genomic CH471060.1 EAW91823.1
      EAW91824.1
      EAW91825.1
      EAW91826.1
      EAW91827.1
      EAW91828.1
      EAW91829.1
    genomic EF094937.1 ABO15003.1
    mRNA AA830489.1 None
    mRNA AK289945.1 BAF82634.1
    mRNA AK294647.1 BAH11832.1
    mRNA AK296902.1 BAH12451.1
    mRNA AK307506.1 None
    mRNA AK315867.1 BAF98758.1
    mRNA BC003623.2 AAH03623.3
    mRNA BC013265.1 None
    mRNA BC051814.1 AAH51814.1
    mRNA BC063824.1 AAH63824.2
    mRNA BC068456.1 AAH68456.2
    mRNA BC070389.1 None
    mRNA BC072426.1 AAH72426.2
    mRNA BC073141.1 AAH73141.1
    mRNA BC083508.1 AAH83508.2
    mRNA BC099904.1 AAH99904.1
    mRNA BC101483.1 AAI01484.1
    mRNA BC108281.1 AAI08282.1
    mRNA BC111951.1 AAI11952.1
    mRNA BM783874.1 None
    mRNA BQ605329.1 None
    mRNA CN276619.1 None
    mRNA CN276627.1 None
    mRNA CR996247.1 None
    mRNA DB472116.1 None
    mRNA DC298291.1 None
    mRNA DQ185048.1 ABD14427.1
    mRNA M86400.1 AAA36446.1
    mRNA S79449.1 AAD14300.1
    mRNA U28964.1 AAC52052.1
    other-genetic DQ891706.2 ABM82632.1
    other-genetic DQ894884.2 ABM85810.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P63104.1 GenPept UniProtKB/Swiss-Prot:P63104
    Q2F831 GenPept UniProtKB/TrEMBL:Q2F831
    Q6LD62 GenPept UniProtKB/TrEMBL:Q6LD62
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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