YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: YES1provided by HGNC
Official Full Name: v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1provided by HGNC
Primary source: HGNC:12841
See related: Ensembl:ENSG00000176105; HPRD:01285; MIM:164880; Vega:OTTHUMG00000131472
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Yes; c-yes; HsT441; P61-YES
Summary: This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 18p11.31-p11.21

Sequence :: Chromosome: 18; NC_000018.9 (721592..812327, complement)

See YES1 in Epigenomics, MapViewer

Chromosome 18 - NC_000018.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Taken together, our findings demonstrate that Yes and Lyn phosphorylate EGFR at Y1101, which influences EGFR nuclear translocation in this model of cetuximab resistance.
Title: Yes and Lyn play a role in nuclear translocation of the epidermal growth factor receptor.
study concludes that Yes is a central mediator for malignant mesothelioma cell growth that is not shared with other Src family kinases such as c-Src
Title: Yes is a central mediator of cell growth in malignant mesothelioma cells.
c-Yes regulates specific oncogenic signalling pathways important for colon cancer progression that is not shared with c-Src.
Title: Specific oncogenic activity of the Src-family tyrosine kinase c-Yes in colon carcinoma cells.
Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3.
Title: Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3.
Yes-associated protein may play important roles in different pathways in distinct lung tumor subtypes.
Title: Differential expression of Yes-associated protein is correlated with expression of cell cycle markers and pathologic TNM staging in non-small-cell lung carcinoma.
c-Yes was expressed in malignant melanoma, and squamous cell carcinoma type skin neoplasms.
Title: Elevated c-Src and c-Yes expression in malignant skin cancers.
Cloning of the complete coding sequence of the cDNA of the Csk and Yes tyrosine kinases genes of the human lymphocytes and retina have been carried out.
Title: Role of the Yes and Csk tyrosine kinases in the development of a pathological state in the human retina.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
Both YES and STAT1 were verified as direct miR-145 targets
Title: MicroRNA-145 targets YES and STAT1 in colon cancer cells.
Study identified the previously reported pathogenic mutation of NTRK3 in a KRAS/BRAF wild-type tumor and 2 somatic mutations in the Src family of kinases (YES1 and LYN) that would be expected to cause structural changes.
Title: Resequencing analysis of the human tyrosine kinase gene family in pancreatic cancer.

Submit: New GeneRIF Correction See all (28)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
P07947	O43184	ADAM12	HPRD	PubMed
P07947	Q13444	ADAM15	HPRD	PubMed
P07947	Q9Y5K6	CD2AP	HPRD	PubMed
P07947	P16671	CD36	HPRD	PubMed
P07947	P15529	CD46	HPRD	PubMed
P07947	P46527	CDKN1B	HPRD	PubMed
P07947	P07333	CSF1R	HPRD	PubMed
P07947	P78352	DLG4	HPRD	PubMed
P07947	Q99704	DOK1	HPRD	PubMed
P07947	P17948	FLT1	HPRD	PubMed
P07947	Q9HCN6	GP6	HPRD	PubMed
P07947	P16144	ITGB4	HPRD	PubMed
P07947	O60674	JAK2	HPRD	PubMed
P07947	P35968	KDR	HPRD	PubMed
P07947	P10721	KIT	HPRD	PubMed
P07947	Q04912	MST1R	HPRD	PubMed
P07947	O60500	NPHS1	HPRD	PubMed
P07947	Q16625	OCLN	HPRD	PubMed
P07947	Q13177	PAK2	HPRD	PubMed
P07947	Q8WUM4	PDCD6IP	HPRD	PubMed
P07947	P09619	PDGFRB	HPRD	PubMed
P07947	P16284	PECAM1	HPRD	PubMed
P07947	P23469	PTPRE	HPRD	PubMed
P07947	P20936	RASA1	HPRD	PubMed
P07947	P27635	RPL10	HPRD	PubMed
P07947	Q13625	TP53BP2	HPRD	PubMed
P07947	Q9HBA0	TRPV4	HPRD	PubMed
P07947	Q06418	TYRO3	HPRD	PubMed
P07947	P07947	YES1	HPRD	PubMed
BioGRID:113357	BioGRID:114287	ADAM15	BioGRID	PubMed	Reconstituted Complex
BioGRID:113357	BioGRID:106901	ARRB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113357	BioGRID:107012	ATP6V1E1	BioGRID	PubMed	Co-fractionation
BioGRID:113357	BioGRID:107315	CBL	BioGRID	PubMed	Reconstituted Complex
BioGRID:113357	BioGRID:107386	CD36	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113357	BioGRID:110346	CD46	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113357	BioGRID:107434	CDH1	BioGRID	PubMed	Reconstituted Complex
BioGRID:113357	BioGRID:107823	CSF1R	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113357	BioGRID:107881	CTNND1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113357	BioGRID:108131	DOK1	BioGRID	PubMed	Reconstituted Complex
BioGRID:113357	BioGRID:112853	DYNLT1	BioGRID	PubMed	Co-fractionation
BioGRID:113357	BioGRID:108309	ELAVL1	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:113357	BioGRID:108362	EPHB2	BioGRID	PubMed	Reconstituted Complex
BioGRID:113357	BioGRID:116806	FAF2	BioGRID	PubMed	Co-fractionation
BioGRID:113357	BioGRID:106852	FASLG	BioGRID	PubMed	Protein-peptide
BioGRID:113357	BioGRID:115506	FLOT1	BioGRID	PubMed	Co-fractionation
BioGRID:113357	BioGRID:108621	FN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113357	BioGRID:108810	FYN	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113357	BioGRID:109428	HNRNPH1	BioGRID	PubMed	Co-fractionation
BioGRID:113357	BioGRID:109552	HSP90AA1	BioGRID	PubMed	Affinity Capture-Luminescence
BioGRID:113357	BioGRID:109821	ILF2	BioGRID	PubMed	Co-fractionation
BioGRID:113357	BioGRID:109920	JAK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113357	BioGRID:115900	KHDRBS1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; FRET; Protein-peptide
BioGRID:113357	BioGRID:110015	KIT	BioGRID	PubMed	Reconstituted Complex
BioGRID:113357	BioGRID:123219	MED28	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113357	BioGRID:110694	MYC	BioGRID	PubMed	Dosage Lethality
BioGRID:113357	BioGRID:201336	Mbp	BioGRID	PubMed	Protein-peptide
BioGRID:113357	BioGRID:110811	NEDD4	BioGRID	PubMed	Reconstituted Complex
BioGRID:113357	BioGRID:110928	NPHS1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113357	BioGRID:111004	OCLN	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113357	BioGRID:114049	OGT	BioGRID	PubMed	Biochemical Activity
BioGRID:113357	BioGRID:115332	PDCD6IP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113357	BioGRID:111201	PECAM1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113357	BioGRID:111719	PTK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113357	BioGRID:111856	RASA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113357	BioGRID:971427	RL2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113357	BioGRID:112054	RPL10	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:113357	BioGRID:114769	SLC9A3R1	BioGRID	PubMed	Reconstituted Complex
BioGRID:113357	BioGRID:114303	SNAP23	BioGRID	PubMed	Co-fractionation
BioGRID:113357	BioGRID:115485	TNK2	BioGRID	PubMed	Reconstituted Complex
BioGRID:113357	BioGRID:121883	TRPV4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113357	BioGRID:120842	TSR1	BioGRID	PubMed	Co-fractionation
BioGRID:113357	BioGRID:214351	Trim69	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113357	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113357	BioGRID:121543	ZNF512B	BioGRID	PubMed	Two-hybrid
BioGRID:113357	BioGRID:1205545	nef	BioGRID	PubMed	Reconstituted Complex

Pathways from BioSystems

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Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
Adherens junction, organism-specific biosystem (from KEGG)
Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
Adherens junction, conserved biosystem (from KEGG)
Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
Alpha-synuclein signaling, organism-specific biosystem (from Pathway Interaction Database)
Alpha-synuclein signaling, organism-specific biosystem
Alpha-synuclein signaling
Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem"Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligand...
CD28 co-stimulation, organism-specific biosystem (from REACTOME)
CD28 co-stimulation, organism-specific biosystemIn naive T cells, CD28 costimulation enhances cell cycle entry, potently stimulates expression of both the mitogenic lymphokine interleukin-2 (IL-2) and its receptor, and stimulates the activation o...
CDC42 signaling events, organism-specific biosystem (from Pathway Interaction Database)
CDC42 signaling events, organism-specific biosystem
CDC42 signaling events
CTLA4 inhibitory signaling, organism-specific biosystem (from REACTOME)
CTLA4 inhibitory signaling, organism-specific biosystemCTLA4 is one of the best studied inhibitory receptors of the CD28 superfamily. CTLA4 inhibits Tcell activation by reducing IL2 production and IL2 expression, and by arresting T cells at the G1 phase ...
CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
CXCR4-mediated signaling events, organism-specific biosystem
CXCR4-mediated signaling events
Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
Class I PI3K signaling events, organism-specific biosystem (from Pathway Interaction Database)
Class I PI3K signaling events, organism-specific biosystem
Class I PI3K signaling events
Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
EPHA forward signaling, organism-specific biosystem (from Pathway Interaction Database)
EPHA forward signaling, organism-specific biosystem
EPHA forward signaling
Ephrin B reverse signaling, organism-specific biosystem (from Pathway Interaction Database)
Ephrin B reverse signaling, organism-specific biosystem
Ephrin B reverse signaling
FCGR activation, organism-specific biosystem (from REACTOME)
FCGR activation, organism-specific biosystemCross-linking of FCGRs with IgG coated immune complexes results in tyrosine phosphorylation of the immuno tyrosine activation motif (ITAMs) of the rececptor by membrane-bound tyrosine kinases of the ...
Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemPhagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phag...
Glypican 1 network, organism-specific biosystem (from Pathway Interaction Database)
Glypican 1 network, organism-specific biosystem
Glypican 1 network
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Interleukin-11 Signaling Pathway, organism-specific biosystem (from WikiPathways)
Interleukin-11 Signaling Pathway, organism-specific biosystemIL-11 is a multifunctional cytokine that belongs to the gp130 family. It was first isolated from a primate bone marrow derived cell line, PU-34 for its ability to stimulate the proliferation of a pla...
Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemThe Interleukin-3 (IL-3), IL-5 and Granulocyte-macrophage colony stimulating factor (GM-CSF) receptors form a family of heterodimeric receptors that have specific alpha chains but share a common beta...
Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
Noncanonical Wnt signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
Noncanonical Wnt signaling pathway, organism-specific biosystem
Noncanonical Wnt signaling pathway
PDGFR-beta signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
PDGFR-beta signaling pathway, organism-specific biosystem
PDGFR-beta signaling pathway
PECAM1 interactions, organism-specific biosystem (from REACTOME)
PECAM1 interactions, organism-specific biosystemPECAM-1/CD31 is a member of the immunoglobulin superfamily (IgSF) and has been implicated to mediate the adhesion and trans-endothelial migration of T-lymphocytes into the vascular wall, T cell activ...
Regulation of KIT signaling, organism-specific biosystem (from REACTOME)
Regulation of KIT signaling, organism-specific biosystemSCF induced proliferation is negatively regulated by various proteins including SHP1, PKC, CBL, SOCS1, SOCS6 and LNK.
Regulation of p38-alpha and p38-beta, organism-specific biosystem (from Pathway Interaction Database)
Regulation of p38-alpha and p38-beta, organism-specific biosystem
Regulation of p38-alpha and p38-beta
Regulation of signaling by CBL, organism-specific biosystem (from REACTOME)
Regulation of signaling by CBL, organism-specific biosystemCbl is an E3 ubiquitin-protein ligase that negatively regulates signaling pathways by targeting proteins for ubiquitination and proteasomal degradation (Rao et al. 2002). Cbl negatively regulates PI3...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by ERBB2, organism-specific biosystem (from REACTOME)
Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
Signaling by Interleukins, organism-specific biosystem (from REACTOME)
Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
Signaling events mediated by PTP1B, organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by PTP1B, organism-specific biosystem
Signaling events mediated by PTP1B
Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
Signaling events mediated by VEGFR1 and VEGFR2
Signaling events mediated by focal adhesion kinase, organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by focal adhesion kinase, organism-specific biosystem
Signaling events mediated by focal adhesion kinase
Thromboxane A2 receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
Thromboxane A2 receptor signaling, organism-specific biosystem
Thromboxane A2 receptor signaling
Tight junction, organism-specific biosystem (from KEGG)
Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
Tight junction, conserved biosystem (from KEGG)
Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
amb2 Integrin signaling, organism-specific biosystem
amb2 Integrin signaling

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

RH68784 (e-PCR)
- UniSTS:49173

STS-R69158 (e-PCR)
- UniSTS:25901

PMC156606P1 (e-PCR)
- UniSTS:271408

D8S2279 (e-PCR)
- UniSTS:473907

L18426 (e-PCR)
- UniSTS:34648

D22S1032 (e-PCR)
- UniSTS:58713

STS-M15990 (e-PCR)
- UniSTS:32861

RH65978 (e-PCR)
- UniSTS:19297

D1S1423 (e-PCR)
- UniSTS:149619

RH69573 (e-PCR)
- UniSTS:86460

GDB:196598 (e-PCR)
- UniSTS:155870

D18S1274 (e-PCR)
- UniSTS:37607

RH69080 (e-PCR)
- UniSTS:76525

Homology

Homologs of the YES1 gene: The YES1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
enzyme binding	IPI Inferred from Physical Interaction more info
epidermal growth factor receptor binding	IEA Inferred from Electronic Annotation more info
ion channel binding	IPI Inferred from Physical Interaction more info	PubMed
non-membrane spanning protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
protein tyrosine kinase activity	EXP Inferred from Experiment more info
protein tyrosine kinase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis	TAS Traceable Author Statement more info
T cell costimulation	TAS Traceable Author Statement more info
blood coagulation	TAS Traceable Author Statement more info
cellular protein modification process	TAS Traceable Author Statement more info	PubMed
glucose transport	IEA Inferred from Electronic Annotation more info
innate immune response	TAS Traceable Author Statement more info
leukocyte migration	TAS Traceable Author Statement more info
protein autophosphorylation	IEA Inferred from Electronic Annotation more info
regulation of vascular permeability	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info
cytoplasm	IDA Inferred from Direct Assay more info
cytosol	TAS Traceable Author Statement more info
microtubule organizing center	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: tyrosine-protein kinase Yes

Names: tyrosine-protein kinase Yes; proto-oncogene c-Yes; cellular yes-1 protein; Yamaguchi sarcoma oncogene; proto-oncogene tyrosine-protein kinase YES

NP_005424.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005433.3 → NP_005424.1 tyrosine-protein kinase Yes

Status: REVIEWED

Source sequence(s)

AU123956, BC031080, BC048960, BU753688, H80401, M15990

Consensus CDS

CCDS11824.1

UniProtKB/Swiss-Prot

P07947

Related

ENSP00000324740, OTTHUMP00000259023, ENST00000314574, OTTHUMT00000441337

Conserved Domains (4) summary

cd05034
Location:270 – 529
Blast Score: 1483

PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases

cd10366
Location:154 – 254
Blast Score: 556

SH2_Src_Yes; Src homology 2 (SH2) domain found in Yes

pfam07714
Location:277 – 526
Blast Score: 1042

Pkinase_Tyr; Protein tyrosine kinase

cd12007
Location:94 – 151
Blast Score: 317

SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000018.9 Reference GRCh37.p10 Primary Assembly

Range

721592..812327, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000150.1 Alternate HuRef

Range

681901..721946, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018929.1 Alternate CHM1_1.0

Range

713493..804196, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01049818.1 (24973..65018)	None
genomic	AMYH01008773.1 (64687..155390)	None
genomic	AP000894.6 (3409..17129)	None
genomic	AP001020.4 (2696..76275)	None
genomic	AP001178.4 (149277..152711)	None
genomic	CH471113.2	EAX01709.1
		EAX01710.1
mRNA	AK314063.1	BAG36767.1
mRNA	AU123956.1	None
mRNA	BC031080.1	None
mRNA	BC048960.1	AAH48960.1
mRNA	BM969640.1	None
mRNA	BU753688.1	None
mRNA	H80401.1	None
mRNA	M15990.1	AAA35735.1