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mhc1uka major histocompatibility complex class I UKA [ Danio rerio (zebrafish) ]

Gene ID: 751750, updated on 27-Mar-2024

Summary

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Official Symbol
mhc1ukaprovided by ZNC
Official Full Name
major histocompatibility complex class I UKAprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060825-152
See related
Ensembl:ENSDARG00000092731 AllianceGenome:ZFIN:ZDB-GENE-060825-152
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
UCA; mhc1uca; Dare-UCA; zgc:153728; si:ch73-213j4.4
Summary
Predicted to be involved in immune response. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: 19
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (7043620..7051403)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (7124693..7132571)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene death-domain associated protein Neighboring gene TAP binding protein (tapasin), tandem duplicate 1 Neighboring gene TAP binding protein (tapasin), tandem duplicate 2 Neighboring gene major histocompatibility complex class I UBA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A contig map of the Mhc class I genomic region in the zebrafish reveals ancient synteny. Michalová V, et al. J Immunol, 2000 May 15. PMID 10799891
  2. Role of zebrafish NLRC5 in antiviral response and transcriptional regulation of MHC related genes. Wu XM, et al. Dev Comp Immunol, 2017 Mar. PMID 27876605
  3. Characterization of the Z lineage Major histocompatability complex class I genes in zebrafish. Dirscherl H, et al. Immunogenetics, 2014 Mar. PMID 24287892, Free PMC Article
  4. Multiple divergent haplotypes express completely distinct sets of class I MHC genes in zebrafish. McConnell SC, et al. Immunogenetics, 2014 Mar. PMID 24291825, Free PMC Article
  5. A nonclassical MHC class I U lineage locus in zebrafish with a null haplotypic variant. Dirscherl H, et al. Immunogenetics, 2015 Sep. PMID 26254596, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC153728

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
major histocompatibility complex class I UKA; uncharacterized protein LOC751750
Names
MHC class I antigen UKA
major histocompatibility complex class I UCA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045460.1 → NP_001038925.1  major histocompatibility complex class I UKA isoform 2 precursor

    See identical proteins and their annotated locations for NP_001038925.1

    Status: PROVISIONAL

    Source sequence(s)
    BC122401
    UniProtKB/TrEMBL
    Q0P3X2
    Conserved Domains (2) summary
    cd07698
    Location:197 → 293
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:19 → 193
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

  2. NM_001423392.1 → NP_001410321.1  major histocompatibility complex class I UKA isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    FP085393
    UniProtKB/TrEMBL
    A0A8M2B625

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    7043620..7051403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159469.4 → XP_005159526.1  uncharacterized protein LOC751750

    Related
    ENSDARP00000117273.2, ENSDART00000133954.4
    Conserved Domains (2) summary
    cd07698
    Location:207 → 300
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:29 → 203
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
Nucleotide Protein
Heading Accession and Version

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