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WNT7B Wnt family member 7B [ Homo sapiens (human) ]

Gene ID: 7477, updated on 8-May-2016
Official Symbol
WNT7Bprovided by HGNC
Official Full Name
Wnt family member 7Bprovided by HGNC
Primary source
HGNC:HGNC:12787
See related
Ensembl:ENSG00000188064 HPRD:03573; MIM:601967; Vega:OTTHUMG00000154636
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008]
Orthologs
Location:
22q13
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 22 NC_000022.11 (45920362..45977128, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (46316246..46373008, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ataxin 10 Neighboring gene tRNA nucleotidyl transferase, CCA-adding, 1 pseudogene Neighboring gene uncharacterized LOC105373071 Neighboring gene uncharacterized LOC105373072 Neighboring gene dynein heavy chain -like pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Basal cell carcinoma, organism-specific biosystem (from KEGG)
    Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • Basal cell carcinoma, conserved biosystem (from KEGG)
    Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
    Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
  • DNA damage response (only ATM dependent), organism-specific biosystem (from WikiPathways)
    DNA damage response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Hedgehog signaling pathway, organism-specific biosystem (from KEGG)
    Hedgehog signaling pathway, organism-specific biosystemThe Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and or...
  • Hedgehog signaling pathway, conserved biosystem (from KEGG)
    Hedgehog signaling pathway, conserved biosystemThe Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and or...
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Melanogenesis, organism-specific biosystem (from KEGG)
    Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
  • Melanogenesis, conserved biosystem (from KEGG)
    Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Signaling by Wnt, organism-specific biosystem (from REACTOME)
    Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
  • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • WNT ligand biogenesis and trafficking, organism-specific biosystem (from REACTOME)
    WNT ligand biogenesis and trafficking, organism-specific biosystem19 WNT proteins have been identified in human cells. The WNTs are members of a conserved metazoan family of secreted morphogens that activate several signaling pathways in the responding cell: the c...
  • Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
  • Wnt signaling, organism-specific biosystem (from KEGG)
    Wnt signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • Wnt signaling, conserved biosystem (from KEGG)
    Wnt signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Wnt signaling network, organism-specific biosystem (from Pathway Interaction Database)
    Wnt signaling network, organism-specific biosystem
    Wnt signaling network
  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
central nervous system vasculogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
chorio-allantoic fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
developmental growth involved in morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic organ development ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic placenta morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
establishment or maintenance of polarity of embryonic epithelium ISS
Inferred from Sequence or Structural Similarity
more info
 
fibroblast proliferation IEP
Inferred from Expression Pattern
more info
PubMed 
forebrain regionalization IEP
Inferred from Expression Pattern
more info
PubMed 
homeostatic process ISS
Inferred from Sequence or Structural Similarity
more info
 
in utero embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
inner medullary collecting duct development ISS
Inferred from Sequence or Structural Similarity
more info
 
lens fiber cell development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
lobar bronchus development ISS
Inferred from Sequence or Structural Similarity
more info
 
lung development ISS
Inferred from Sequence or Structural Similarity
more info
 
lung epithelium development ISS
Inferred from Sequence or Structural Similarity
more info
 
lung morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
mammary gland epithelium development IEP
Inferred from Expression Pattern
more info
PubMed 
metanephric collecting duct development ISS
Inferred from Sequence or Structural Similarity
more info
 
metanephric epithelium development ISS
Inferred from Sequence or Structural Similarity
more info
 
metanephric loop of Henle development ISS
Inferred from Sequence or Structural Similarity
more info
 
metanephros morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
outer medullary collecting duct development ISS
Inferred from Sequence or Structural Similarity
more info
 
oxygen homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
renal inner medulla development ISS
Inferred from Sequence or Structural Similarity
more info
 
renal outer medulla development ISS
Inferred from Sequence or Structural Similarity
more info
 
stem cell proliferation IEP
Inferred from Expression Pattern
more info
PubMed 
synapse organization ISS
Inferred from Sequence or Structural Similarity
more info
 
trachea cartilage morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi lumen TAS
Traceable Author Statement
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein Wnt-7b
Names
wingless-type MMTV integration site family member 7B
wingless-type MMTV integration site family, member 7B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_058238.2NP_478679.1  protein Wnt-7b precursor

    See identical proteins and their annotated locations for NP_478679.1

    Status: REVIEWED

    Source sequence(s)
    AB062766, AF416743, BX511035, CB853639, CR536603
    Consensus CDS
    CCDS33667.1
    UniProtKB/Swiss-Prot
    P56706
    Related
    ENSP00000341032, OTTHUMP00000206327, ENST00000339464, OTTHUMT00000336418
    Conserved Domains (1) summary
    pfam00110
    Location:37349
    wnt; wnt family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p2 Primary Assembly

    Range
    45920362..45977128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530366.1XP_011528668.1  

    See identical proteins and their annotated locations for XP_011528668.1

    UniProtKB/TrEMBL
    A8K0G1
    Related
    ENSP00000386546, OTTHUMP00000206329, ENST00000409496, OTTHUMT00000336420
    Conserved Domains (1) summary
    pfam00110
    Location:41353
    wnt; wnt family

Alternate CHM1_1.1

Genomic

  1. NC_018933.2 Alternate CHM1_1.1

    Range
    46275362..46332075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)