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WNT7A Wnt family member 7A [ Homo sapiens (human) ]

Gene ID: 7476, updated on 12-May-2016
Official Symbol
WNT7Aprovided by HGNC
Official Full Name
Wnt family member 7Aprovided by HGNC
Primary source
HGNC:HGNC:12786
See related
Ensembl:ENSG00000154764 HPRD:03341; MIM:601570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008]
Orthologs
Location:
3p25
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (13818217..13880121, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (13860082..13921618, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100293612 Neighboring gene long intergenic non-protein coding RNA 620 Neighboring gene transfer RNA suppressor (CTA) 2-1 Neighboring gene uncharacterized LOC105376957 Neighboring gene vomeronasal 1 receptor 20 pseudogene Neighboring gene FYVE, RhoGEF and PH domain containing 5 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Fuhrmann syndrome
MedGen: C1856728 OMIM: 228930 GeneReviews: Not available
Compare labs
Ulna and fibula absence of with severe limb deficiency
MedGen: C1848651 OMIM: 276820 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
NHGRI GWA Catalog
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor agonist activity IC
Inferred by Curator
more info
PubMed 
receptor agonist activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway involved in wound healing, spreading of epidermal cells IDA
Inferred from Direct Assay
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
asymmetric protein localization IEA
Inferred from Electronic Annotation
more info
 
axonogenesis TAS
Traceable Author Statement
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cartilage condensation IDA
Inferred from Direct Assay
more info
PubMed 
cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
 
cell proliferation in forebrain IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to transforming growth factor beta stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
central nervous system vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
cerebellar granule cell differentiation IEA
Inferred from Electronic Annotation
more info
 
chondrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
dorsal/ventral pattern formation IEA
Inferred from Electronic Annotation
more info
 
embryonic axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic forelimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic hindlimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 
excitatory synapse assembly TAS
Traceable Author Statement
more info
PubMed 
lens fiber cell development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
 
non-canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
oviduct development IEA
Inferred from Electronic Annotation
more info
 
palate development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell proliferation involved in wound healing IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of excitatory postsynaptic potential IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of excitatory synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein localization to synapse TAS
Traceable Author Statement
more info
PubMed 
positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of axon diameter IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
sex differentiation TAS
Traceable Author Statement
more info
PubMed 
skeletal muscle satellite cell activation IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA
Inferred from Electronic Annotation
more info
 
somatic stem cell division IEA
Inferred from Electronic Annotation
more info
 
somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
stem cell development IDA
Inferred from Direct Assay
more info
PubMed 
synapse assembly TAS
Traceable Author Statement
more info
PubMed 
synaptic vesicle recycling TAS
Traceable Author Statement
more info
PubMed 
uterus morphogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi lumen TAS
Traceable Author Statement
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
presynapse IEA
Inferred from Electronic Annotation
more info
 
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein Wnt-7a
Names
proto-oncogene Wnt7a protein
wingless-type MMTV integration site family member 7A
wingless-type MMTV integration site family, member 7A

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008088.1 RefSeqGene

    Range
    5001..66537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004625.3NP_004616.2  protein Wnt-7a precursor

    See identical proteins and their annotated locations for NP_004616.2

    Status: REVIEWED

    Source sequence(s)
    BC008811
    Consensus CDS
    CCDS2616.1
    UniProtKB/Swiss-Prot
    O00755
    Related
    ENSP00000285018, OTTHUMP00000160234, ENST00000285018, OTTHUMT00000252031
    Conserved Domains (1) summary
    pfam00110
    Location:37349
    wnt; wnt family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    13818217..13880121 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534091.1XP_011532393.1  

    See identical proteins and their annotated locations for XP_011532393.1

    Conserved Domains (1) summary
    pfam00110
    Location:1282
    wnt; wnt family
  2. XM_011534090.1XP_011532392.1  

    See identical proteins and their annotated locations for XP_011532392.1

    Conserved Domains (1) summary
    pfam00110
    Location:1282
    wnt; wnt family

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    13810090..13871973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)