WNT5A wingless-type MMTV integration site family, member 5A [ Homo sapiens ]

Gene ID: 7474, updated on 5-Feb-2012

Help top of page

Summary

Official Symbol: WNT5Aprovided by HGNC
Official Full Name: wingless-type MMTV integration site family, member 5Aprovided by HGNC
Primary source: HGNC:12784
See related: Ensembl:ENSG00000114251; HPRD:01293; MIM:164975; Vega:OTTHUMG00000158361
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: hWNT5A
Summary: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Help top of page

Genomic context

Location :: 3p21-p14

Sequence :: Chromosome: 3; NC_000003.11 (55499743..55521331, complement)

See WNT5A in Epigenomics, MapViewer

Chromosome 3 - NC_000003.11 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Differentiation paralleled the activation of Wnt5/Calmodulin signalling by autocrine/paracrine intense secretion of Wnt5a and Wnt5b
Title: Mesodermal progenitor cells (MPCs) differentiate into mesenchymal stromal cells (MSCs) by activation of Wnt5/calmodulin signalling pathway.
GPC6 promotes invasive migration by inhibition of canonical beta-catenin and Wnt signalling, and up-regulation of non-canonical Wnt5A signalling leading to the activation of JNK and p38 MAPK.
Title: NFAT promotes carcinoma invasive migration through glypican-6.
loss of Wnt5a predicts poor outcome in Epithelial ovarian cancer patients and Wnt5a suppresses the growth of cancer cells by triggering cellular senescence
Title: Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence.
under high levels of Wnt5a monocytes could differentiate into unconventional dendritic cells with tolerogenic features.
Title: Wnt5a skews dendritic cell differentiation to an unconventional phenotype with tolerogenic features.
Wnt5a plays an important role in human hindgut and anorectal morphogenesis.
Title: Spatiotemporal expression of Wnt5a during the development of the hindgut and anorectum in human embryos.
The loss of Wnt-5 may indicate the invasiveness of extramammary Paget's disease.
Title: Loss of Wnt-5α is associated with an invasive phenotype of extramammary Paget's disease.
Several members of the WNT pathway, including WNT5A, FZD5, and DKK1 were highly up-regulated in PCa tissue from patients with advanced PCa.
Title: Expression profile of WNT molecules in prostate cancer and its regulation by aminobisphosphonates.
The expression of Wnt5A is significantly increased in chronic rhinosinusitis with nasal polyps compared with controls.
Title: [Up-regulation of Wnt5A in chronic rhinosinusitis with nasal polyps].
Wnt5a methylation was strongly associated with tumour microsatellite instability tumours after adjustment for age, sex, and tumour location
Title: Promoter methylation of Wnt5a is associated with microsatellite instability and BRAF V600E mutation in two large populations of colorectal cancer patients.
Wnt5a was prominently expressed in human primary cytotrophoblast cells, but absent in the human choriocarcinoma cell line JAR.
Title: Effects of Wnt5a protein on proliferation and apoptosis in JAR choriocarcinoma cells.

Submit: New GeneRIF Correction See all (110)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Robinow syndrome, autosomal dominant

MIM: 180700

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
P41221	Q9UP38	FZD1	HPRD	PubMed
P41221	Q13467	FZD5	HPRD	PubMed
P41221	Q01974	ROR2	HPRD	PubMed
BioGRID:113311	BioGRID:113917	FZD1	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
cytokine activity	IEA Inferred from Electronic Annotation more info
frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
frizzled-2 binding	IBA Inferred from Biological aspect of Ancestor more info
protein domain specific binding	IEA Inferred from Electronic Annotation more info
receptor agonist activity	IC Inferred by Curator more info	PubMed
receptor binding	IEA Inferred from Electronic Annotation more info
receptor tyrosine kinase-like orphan receptor binding	IPI Inferred from Physical Interaction more info	PubMed
sequence-specific DNA binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
Wnt receptor signaling pathway	IDA Inferred from Direct Assay more info
Wnt receptor signaling pathway	IEA Inferred from Electronic Annotation more info
Wnt receptor signaling pathway, calcium modulating pathway	IDA Inferred from Direct Assay more info	PubMed
Wnt receptor signaling pathway, calcium modulating pathway	IMP Inferred from Mutant Phenotype more info	PubMed
Wnt receptor signaling pathway, planar cell polarity pathway	IBA Inferred from Biological aspect of Ancestor more info
activation of JUN kinase activity	IDA Inferred from Direct Assay more info
activation of JUN kinase activity	IMP Inferred from Mutant Phenotype more info
activation of MAPK activity	IDA Inferred from Direct Assay more info
activation of protein kinase B activity	IDA Inferred from Direct Assay more info
ameboidal cell migration	IEA Inferred from Electronic Annotation more info
anterior/posterior axis specification, embryo	IEA Inferred from Electronic Annotation more info
axis elongation	IEA Inferred from Electronic Annotation more info
axon guidance	ISS Inferred from Sequence or Structural Similarity more info
cellular protein localization	IDA Inferred from Direct Assay more info	PubMed
cellular response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
cellular response to interferon-gamma	IEP Inferred from Expression Pattern more info	PubMed
cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
cellular response to retinoic acid	ISS Inferred from Sequence or Structural Similarity more info
cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
cervix development	IBA Inferred from Biological aspect of Ancestor more info
cochlea morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
convergent extension involved in organogenesis	IBA Inferred from Biological aspect of Ancestor more info
digestive tract morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
dopaminergic neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
dorsal/ventral axis specification	IBA Inferred from Biological aspect of Ancestor more info
embryo development	IEA Inferred from Electronic Annotation more info
embryonic digit morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
embryonic skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
epithelial cell proliferation involved in mammary gland duct elongation	IBA Inferred from Biological aspect of Ancestor more info
epithelial to mesenchymal transition	IEP Inferred from Expression Pattern more info	PubMed
establishment of planar polarity	IEA Inferred from Electronic Annotation more info
face development	IMP Inferred from Mutant Phenotype more info	PubMed
genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
heart looping	IBA Inferred from Biological aspect of Ancestor more info
hemopoietic stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
hindgut morphogenesis	IEA Inferred from Electronic Annotation more info
hypophysis morphogenesis	IEA Inferred from Electronic Annotation more info
keratinocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
lateral sprouting involved in mammary gland duct morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
lens development in camera-type eye	ISS Inferred from Sequence or Structural Similarity more info	PubMed
lung alveolus development	IEA Inferred from Electronic Annotation more info
male gonad development	IEP Inferred from Expression Pattern more info	PubMed
mammary gland branching involved in thelarche	IBA Inferred from Biological aspect of Ancestor more info
mesenchymal-epithelial cell signaling	IEA Inferred from Electronic Annotation more info
metestrus	IEA Inferred from Electronic Annotation more info
midgut development	IEA Inferred from Electronic Annotation more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
negative chemotaxis	IEA Inferred from Electronic Annotation more info
negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of axon extension involved in axon guidance	IEA Inferred from Electronic Annotation more info
negative regulation of canonical Wnt receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of canonical Wnt receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
negative regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info
negative regulation of fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
negative regulation of mesenchymal cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of prostatic bud formation	IEA Inferred from Electronic Annotation more info
negative regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
neural tube closure	IBA Inferred from Biological aspect of Ancestor more info
neural tube development	IEA Inferred from Electronic Annotation more info
neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
neuron projection morphogenesis	IEA Inferred from Electronic Annotation more info
olfactory bulb interneuron development	ISS Inferred from Sequence or Structural Similarity more info
optic cup formation involved in camera-type eye development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
palate development	IMP Inferred from Mutant Phenotype more info	PubMed
pericardium morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	IEA Inferred from Electronic Annotation more info
planar cell polarity pathway involved in cardiac right atrium morphogenesis	IEA Inferred from Electronic Annotation more info
planar cell polarity pathway involved in neural tube closure	IEA Inferred from Electronic Annotation more info
planar cell polarity pathway involved in outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
planar cell polarity pathway involved in pericardium morphogenesis	IEA Inferred from Electronic Annotation more info
planar cell polarity pathway involved in ventricular septum morphogenesis	IEA Inferred from Electronic Annotation more info
positive regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of T cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cGMP metabolic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cartilage development	IBA Inferred from Biological aspect of Ancestor more info
positive regulation of cell-cell adhesion mediated by cadherin	IEA Inferred from Electronic Annotation more info
positive regulation of chemokine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cytokine secretion involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of fibroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of interferon-gamma production	IEA Inferred from Electronic Annotation more info
positive regulation of interleukin-1 beta secretion	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of interleukin-8 secretion	IEA Inferred from Electronic Annotation more info
positive regulation of macrophage activation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of meiosis	IEA Inferred from Electronic Annotation more info
positive regulation of mesenchymal cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of ossification	IMP Inferred from Mutant Phenotype more info
positive regulation of peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of peptidyl-threonine phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of protein kinase C signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of response to cytokine stimulus	IDA Inferred from Direct Assay more info	PubMed
positive regulation of thymocyte apoptosis	IBA Inferred from Biological aspect of Ancestor more info
positive regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of type I interferon-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
primitive streak formation	IBA Inferred from Biological aspect of Ancestor more info
prostate gland development	IEA Inferred from Electronic Annotation more info
regulation of branching involved in mammary gland duct morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
respiratory system development	IBA Inferred from Biological aspect of Ancestor more info
response to estradiol stimulus	IEA Inferred from Electronic Annotation more info
response to glucocorticoid stimulus	IEA Inferred from Electronic Annotation more info
response to hyperoxia	IEA Inferred from Electronic Annotation more info
response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
response to testosterone stimulus	IEA Inferred from Electronic Annotation more info
signal transduction	IC Inferred by Curator more info	PubMed
somitogenesis	IBA Inferred from Biological aspect of Ancestor more info
tail morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
type B pancreatic cell development	IBA Inferred from Biological aspect of Ancestor more info
urinary bladder development	IBA Inferred from Biological aspect of Ancestor more info
uterus development	IBA Inferred from Biological aspect of Ancestor more info
vagina development	IBA Inferred from Biological aspect of Ancestor more info
wound healing	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
cell surface	IEA Inferred from Electronic Annotation more info
cytoplasm	IEA Inferred from Electronic Annotation more info
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	IDA Inferred from Direct Assay more info
membrane fraction	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
proteinaceous extracellular matrix	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: protein Wnt-5a

Names: protein Wnt-5a; WNT-5A protein

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_031992.1 RefSeqGene

Range

5001..26928

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001256105.1 → NP_001243034.1 protein Wnt-5a isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC121764, AK290869, BU742635, DB224740

UniProtKB/Swiss-Prot

P41221

Conserved Domains (2) summary

smart00097
Location:56 – 365
Blast Score: 1318

WNT1; found in Wnt-1

pfam00110
Location:53 – 365
Blast Score: 1300

wnt; wnt family
NM_003392.4 → NP_003383.2 protein Wnt-5a isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC121764, AK090582, BC064694, BU742635

Consensus CDS

CCDS46850.1

UniProtKB/TrEMBL

B3KQX9

UniProtKB/Swiss-Prot

P41221

Related

ENSP00000264634, ENST00000264634

Conserved Domains (2) summary

smart00097
Location:71 – 380
Blast Score: 1327

WNT1; found in Wnt-1

pfam00110
Location:68 – 380
Blast Score: 1308

wnt; wnt family

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000003.11 Reference GRCh37.p5 Primary Assembly

Range

55499743..55521331, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000135.1 Alternate HuRef

Range

55548623..55570141, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC121764.2 (138337..159925)	None
genomic	CH471055.1	EAW65310.1
		EAW65311.1
genomic	CQ970116.1	CAI38645.1
genomic	GN095169.1	CAY02596.1
genomic	GN368162.1	CAY86018.1
genomic	U39837.1	None
mRNA	AI634753.1	None
mRNA	AK021503.1	None
mRNA	AK090582.1	BAG52191.1
mRNA	AK290375.1	BAF83064.1
mRNA	AK290869.1	BAF83558.1
mRNA	AU118341.2	None
mRNA	BC064694.1	AAH64694.1
mRNA	BC074783.2	AAH74783.2
mRNA	BF218039.1	None
mRNA	BM728706.1	None
mRNA	BU742635.1	None
mRNA	DB224740.1	None
mRNA	EF028086.1	ABK20872.1
mRNA	L20861.1	AAA16842.1
other-genetic	JF432410.1	ADZ15627.1

Protein Accession	Links
Protein Accession	GenePept Link	UniProtKB Link
A0FKN4	GenPept	UniProtKB/TrEMBL:A0FKN4
P41221.2	GenPept	UniProtKB/Swiss-Prot:P41221
Q6DK41	GenPept	UniProtKB/TrEMBL:Q6DK41