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VRK1 vaccinia related kinase 1 [ Homo sapiens (human) ]

Gene ID: 7443, updated on 8-Feb-2015
Official Symbol
VRK1provided by HGNC
Official Full Name
vaccinia related kinase 1provided by HGNC
Primary source
HGNC:HGNC:12718
See related
Ensembl:ENSG00000100749; HPRD:03701; MIM:602168; Vega:OTTHUMG00000171459
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCH1; PCH1A
Summary
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]
Orthologs
See VRK1 in MapViewer
Location:
14q32
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 14 NC_000014.9 (96797347..96881614)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (97263684..97347951)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene poly(A) polymerase alpha Neighboring gene uncharacterized LOC102724667 Neighboring gene long intergenic non-protein coding RNA 618 Neighboring gene uncharacterized LOC101929241

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Pontocerebellar hypoplasia type 1
MedGen: C1843504 OMIM: 607596 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.
NHGRI GWA Catalog
Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections.
NHGRI GWA Catalog
Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
NHGRI GWA Catalog
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Clearance of Nuclear Envelope Membranes from Chromatin, organism-specific biosystem (from REACTOME)
    Clearance of Nuclear Envelope Membranes from Chromatin, organism-specific biosystemIn mitotic prophase, chromatin detaches from the nuclear envelope, and this contributes to the nuclear envelope breakdown. VRK1 (and possibly VRK2) mediated phosphorylation of BANF1 (BAF), a protein ...
  • Initiation of Nuclear Envelope Reformation, organism-specific biosystem (from REACTOME)
    Initiation of Nuclear Envelope Reformation, organism-specific biosystemReassembly of the nuclear envelope is initiated at late anaphase/early telophase when BANF1 (BAF) accumulates on the decondensing chromosome mass close to the spindle ('core' region), together with E...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
  • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
  • Mitotic Prophase, organism-specific biosystem (from REACTOME)
    Mitotic Prophase, organism-specific biosystemDuring prophase, the chromatin in the nucleus condenses, and the nucleolus disappears. Centrioles begin moving to the opposite poles or sides of the cell. Some of the fibers that extend from the cen...
  • Nuclear Envelope Breakdown, organism-specific biosystem (from REACTOME)
    Nuclear Envelope Breakdown, organism-specific biosystemThe nuclear envelope breakdown (NEBD) happens in late prophase of mitosis and involves disassembly of the nuclear pore complex, depolymerization of the nuclear lamina, and clearance of nuclear envelo...
  • Nuclear Envelope Reassembly, organism-specific biosystem (from REACTOME)
    Nuclear Envelope Reassembly, organism-specific biosystemThe reassembly of the nuclear envelope (NE) around separated sister chromatids begins in late anaphase and is completed in telophase. Nuclear pore complexes (NPCs) reassemble and insert into the refo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC117401, MGC138280, MGC142070

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
histone kinase activity (H3-S10 specific) IDA
Inferred from Direct Assay
more info
PubMed 
histone kinase activity (H3-T3 specific) IDA
Inferred from Direct Assay
more info
PubMed 
nucleosomal histone binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Golgi disassembly IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
histone H3-S10 phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H3-T3 phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
mitotic cell cycle TAS
Traceable Author Statement
more info
 
mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
mitotic nuclear envelope disassembly TAS
Traceable Author Statement
more info
 
mitotic nuclear envelope reassembly TAS
Traceable Author Statement
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
Golgi stack IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
spindle IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
serine/threonine-protein kinase VRK1
Names
serine/threonine-protein kinase VRK1
vaccinia virus B1R-related kinase 1
vaccinia-related kinase 1
NP_003375.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016293.1 RefSeqGene

    Range
    5001..89268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003384.2NP_003375.1  serine/threonine-protein kinase VRK1

    See proteins identical to NP_003375.1

    Status: REVIEWED

    Source sequence(s)
    AL133168, BU535261, CA436761
    Consensus CDS
    CCDS9947.1
    UniProtKB/Swiss-Prot
    Q99986
    Related
    ENSP00000216639, OTTHUMP00000246088, ENST00000216639, OTTHUMT00000413520
    Conserved Domains (2) summary
    smart00220
    Location:37293
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14122
    Location:26326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38 Primary Assembly

    Range
    96797347..96881614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720247.1XP_006720310.1  

    See proteins identical to XP_006720310.1

    Conserved Domains (2) summary
    smart00220
    Location:37293
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14122
    Location:26326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
  2. XM_005268041.2XP_005268098.2  

    Conserved Domains (2) summary
    smart00220
    Location:37293
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14122
    Location:26326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 Alternate CHM1_1.1

    Range
    97202026..97286310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000146.1 Alternate HuRef

    Range
    77447214..77531474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)