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VBP1 VHL binding protein 1 [ Homo sapiens (human) ]

Gene ID: 7411, updated on 26-May-2016
Official Symbol
VBP1provided by HGNC
Official Full Name
VHL binding protein 1provided by HGNC
Primary source
HGNC:HGNC:12662
See related
Ensembl:ENSG00000155959 HPRD:02135; MIM:300133; Vega:OTTHUMG00000022666
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PFD3; PFDN3; VBP-1; HIBBJ46
Summary
The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Jan 2015]
Orthologs
Location:
Xq28
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (155197007..155239841)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (154425290..154468098)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene mature T-cell proliferation 1 Neighboring gene C-x(9)-C motif containing 4 Neighboring gene BRCA1/BRCA2-containing complex subunit 3 Neighboring gene RAB39B, member RAS oncogene family Neighboring gene chloride intracellular channel 2 Neighboring gene twinfilin 1 pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Systematic yeast two-hybrid screenings identify von Hippel-Lindau binding protein 1 (VBP1) as cellular binding partners of HIV-1 integrase PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with von Hippel-Lindau binding protein 1 (VBP1; PFD3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
 
protein folding IEA
Inferred from Electronic Annotation
more info
 
tubulin complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
polysome IBA
Inferred from Biological aspect of Ancestor
more info
 
prefoldin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
prefoldin subunit 3
Names
VHL binding protein-1
von Hippel-Lindau binding protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013269.2 RefSeqGene

    Range
    24418..47835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001303543.1NP_001290472.1  prefoldin subunit 3 isoform 2

    See identical proteins and their annotated locations for NP_001290472.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) initiates transcription at an alternate position and has a longer 5' terminal exon than variant 1. It initiates translation at an alternate start codon and the encoded isoform (2) has a longer N-terminus than isoform 1.
    Source sequence(s)
    AA626259, BC009570, BX682237, U96759
    UniProtKB/Swiss-Prot
    P61758
    UniProtKB/TrEMBL
    D3DWY7
    Conserved Domains (1) summary
    cd00584
    Location:86217
    Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...
  2. NM_001303544.1NP_001290473.1  prefoldin subunit 3 isoform 3

    See identical proteins and their annotated locations for NP_001290473.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA626259, AK301646, BC009570
    Consensus CDS
    CCDS78525.1
    UniProtKB/TrEMBL
    B4DWR3
    Related
    ENSP00000438694, OTTHUMP00000276301, ENST00000535916, OTTHUMT00000058807
    Conserved Domains (1) summary
    cd00584
    Location:45176
    Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...
  3. NM_001303545.1NP_001290474.1  prefoldin subunit 3 isoform 4

    See identical proteins and their annotated locations for NP_001290474.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AA626259, BC009570, BC040002, DA610631
    UniProtKB/Swiss-Prot
    P61758
    UniProtKB/TrEMBL
    Q6FH24
    Conserved Domains (1) summary
    cd00584
    Location:13144
    Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...
  4. NM_003372.6NP_003363.1  prefoldin subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_003363.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AA626259, BC009570, BC046094, DA610631
    Consensus CDS
    CCDS14765.1
    UniProtKB/Swiss-Prot
    P61758
    Related
    ENSP00000286428, OTTHUMP00000024252, ENST00000286428, OTTHUMT00000058806
    Conserved Domains (1) summary
    cd00584
    Location:50181
    Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    155197007..155239841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    154336974..154379789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)