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    VASP vasodilator-stimulated phosphoprotein [ Homo sapiens (human) ]

    Gene ID: 7408, updated on 11-May-2013
    Official Symbol
    VASPprovided by HGNC
    Official Full Name
    vasodilator-stimulated phosphoproteinprovided by HGNC
    Primary source
    HGNC:12652
    See related
    Ensembl:ENSG00000125753; HPRD:03415; MIM:601703; Vega:OTTHUMG00000182124
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]
    Location :
    19q13.32
    Sequence :
    Chromosome: 19; NC_000019.9 (46010688..46030241)
    See VASP in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene reticulon 2 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) Neighboring gene optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) Neighboring gene G protein-coupled receptor 4

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description
    NP_003361.1 NP_061916.3 APBB1IP    BIND  PubMed RIAM interacts with VASP. 
    NP_003361.1 NP_056456.1 TES    BIND  PubMed TES interacts with VASP. 
    P50552 Q8IZP0 ABI1    HPRD  PubMed  
    P50552 P68133 ACTA1    HPRD  PubMed  
    P50552 P63261 ACTG1    HPRD  PubMed  
    P50552 O00213 APBB1    HPRD  PubMed  
    P50552 Q7Z5R6 APBB1IP    HPRD  PubMed  
    P50552 DMRTB1 DMRTB1    HPRD  PubMed  
    P50552 Q96PL5 ERMAP    HPRD  PubMed  
    P50552 O15117 FYB    HPRD  PubMed  
    P50552 P06396 GSN    HPRD  PubMed  
    P50552 Q93052 LPP    HPRD  PubMed  
    P50552 O60936 NOL3    HPRD  PubMed  
    P50552 P07737 PFN1    HPRD  PubMed  
    P50552 P35080 PFN2    HPRD  PubMed  
    P50552 O15162 PLSCR1    HPRD  PubMed  
    P50552 P17612 PRKACA    HPRD  PubMed  
    P50552 P14619 PRKG1    HPRD  PubMed  
    P50552 P02549 SPTA1    HPRD  PubMed  
    P50552 Q9UGI8 TES    HPRD  PubMed  
    P50552 Q9C026 TRIM9    HPRD  PubMed  
    P50552 P50552 VASP    HPRD  PubMed  
    P50552 P18206 VCL    HPRD  PubMed  
    P50552 P42768 WAS    HPRD  PubMed  
    P50552 O00308 WWP2    HPRD  PubMed  
    P50552 Q96QU8 XPO6    HPRD  PubMed  
    P50552 Q15942 ZYX    HPRD  PubMed  
    BioGRID:113251 BioGRID:106557 ACAT2    BioGRID  PubMed Co-fractionation 
    BioGRID:113251 BioGRID:127557 AMOT    BioGRID  PubMed Co-fractionation 
    BioGRID:113251 BioGRID:106819 APBB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113251 BioGRID:107011 ATP6V1C1    BioGRID  PubMed Co-fractionation 
    BioGRID:113251 BioGRID:114710 ATP6V1F    BioGRID  PubMed Co-fractionation 
    BioGRID:113251 BioGRID:114412 CPNE3    BioGRID  PubMed Co-fractionation 
    BioGRID:113251 BioGRID:114028 CUL4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113251 BioGRID:108009 DDB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113251 BioGRID:108019 DDX1    BioGRID  PubMed Co-fractionation 
    BioGRID:113251 BioGRID:122012 DMRTB1    BioGRID  PubMed Two-hybrid 
    BioGRID:113251 BioGRID:116869 DNMBP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113251 BioGRID:108489 FAT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113251 BioGRID:108621 FN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113251 BioGRID:128769 FOXK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113251 BioGRID:108809 FYB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113251 BioGRID:109142 GRB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113251 BioGRID:109863 IRAK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113251 BioGRID:109883 ITGA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113251 BioGRID:114477 NOL3    BioGRID  PubMed Two-hybrid 
    BioGRID:113251 BioGRID:109407 NR4A1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113251 BioGRID:114019 NSMAF    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113251 BioGRID:123191 PAAF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113251 BioGRID:111237 PFN1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113251 BioGRID:111238 PFN2    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid 
    BioGRID:113251 BioGRID:111373 PLSCR1    BioGRID  PubMed Two-hybrid 
    BioGRID:113251 BioGRID:115542 POP7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113251 BioGRID:127414 PPP4R2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113251 BioGRID:115688 PRMT5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113251 BioGRID:120792 PRPF40A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113251 BioGRID:111659 PSMA5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113251 BioGRID:122380 RAPH1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113251 BioGRID:115808 RPP38    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113251 BioGRID:112210 SAT1    BioGRID  PubMed Two-hybrid 
    BioGRID:113251 BioGRID:116146 SF3A3    BioGRID  PubMed Co-fractionation 
    BioGRID:113251 BioGRID:116188 SF3B2    BioGRID  PubMed Co-fractionation 
    BioGRID:113251 BioGRID:114231 SRSF9    BioGRID  PubMed Co-fractionation 
    BioGRID:113251 BioGRID:117572 TES    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113251 BioGRID:125280 TRIM9    BioGRID  PubMed Two-hybrid 
    BioGRID:113251 BioGRID:113102 TSG101    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113251 BioGRID:112557 UAP1    BioGRID  PubMed Co-fractionation 
    BioGRID:113251 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113251 BioGRID:113182 UBE2N    BioGRID  PubMed Co-fractionation 
    BioGRID:113251 BioGRID:113251 VASP    BioGRID  PubMed Co-purification; Reconstituted Complex 
    BioGRID:113251 BioGRID:113255 VCAM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113251 BioGRID:113257 VCL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113251 BioGRID:113293 WAS    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113251 BioGRID:116244 WWP2    BioGRID  PubMed Two-hybrid 
    BioGRID:113251 BioGRID:116821 XPO6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113251 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113251 BioGRID:113569 ZYX    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Cell junction organization, organism-specific biosystem (from REACTOME)
      Cell junction organization, organism-specific biosystem
      Cell junction organization
    • Cell-Cell communication, organism-specific biosystem (from REACTOME)
      Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
    • Cell-extracellular matrix interactions, organism-specific biosystem (from REACTOME)
      Cell-extracellular matrix interactions, organism-specific biosystemCellâ??extracellular matrix (ECM) interactions play a critical role in regulating a variety of cellular processes in multicellular organisms including motility, shape change, survival, proliferation ...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • E-cadherin signaling in keratinocytes, organism-specific biosystem (from Pathway Interaction Database)
      E-cadherin signaling in keratinocytes, organism-specific biosystem
      E-cadherin signaling in keratinocytes
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Generation of second messenger molecules, organism-specific biosystem (from REACTOME)
      Generation of second messenger molecules, organism-specific biosystemIn addition to serving as a scaffold via auto-phosphorylation, ZAP-70 also phosphorylates a restricted set of substrates following TCR stimulation - including LAT and SLP-76. These substrates have be...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Signaling by Robo receptor, organism-specific biosystem (from REACTOME)
      Signaling by Robo receptor, organism-specific biosystemThe Roundabout (Robo) family encodes transmembrane receptors that regulate axonal guidance and cell migration. The major function of the Robo receptors is to mediate repulsion of the navigating growt...
    • Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem (from Pathway Interaction Database)
      Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem
      Stabilization and expansion of the E-cadherin adherens junction
    • TCR signaling, organism-specific biosystem (from REACTOME)
      TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    profilin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    actin polymerization or depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    axon guidance TAS
    Traceable Author Statement
    more info
     
    cell junction assembly TAS
    Traceable Author Statement
    more info
     
    neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    actin cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    filopodium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion IDA
    Inferred from Direct Assay
    more info
     
    lamellipodium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    vasodilator-stimulated phosphoprotein
    Names
    vasodilator-stimulated phosphoprotein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003370.3NP_003361.1  vasodilator-stimulated phosphoprotein

      Status: REVIEWED

      Source sequence(s)
      BC038224, BG751094, BG825983, Z46389
      Consensus CDS
      CCDS33051.1
      UniProtKB/Swiss-Prot
      P50552
      Related
      ENSP00000245932, OTTHUMP00000268455, ENST00000245932, OTTHUMT00000459589
      Conserved Domains (1) summary
      cd01207
      Location:3108
      Blast Score: 514
      Ena-Vasp; Enabled-VASP-type homology (EVH1) domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p10 Primary Assembly

      Range
      46010688..46030241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      42440143..42459463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018930.1 Alternate CHM1_1.0

      Range
      46200329..46219974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001008736.1: Suppressed sequence

      Description
      NM_001008736.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

      Supplemental Content

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