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Plce1 phospholipase C, epsilon 1 [ Mus musculus (house mouse) ]

Gene ID: 74055, updated on 3-May-2016
Official Symbol
Plce1provided by MGI
Official Full Name
phospholipase C, epsilon 1provided by MGI
Primary source
MGI:MGI:1921305
See related
Ensembl:ENSMUSG00000024998 Vega:OTTMUSG00000043393
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Plce; mKIAA1516; PLCepsilon; 4933403A21Rik
Orthologs
Location:
19; 19 D1
Exon count:
36
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 19 NC_000085.6 (38481114..38785105)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (38598687..38859595)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4E pseudogene Neighboring gene solute carrier family 35, member G1 Neighboring gene adaptor protein complex AP-2, mu1 pseudogene Neighboring gene NOC3 like DNA replication regulator Neighboring gene TBC1D12: TBC1 domain family, member 12

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Ras GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
glomerulus development ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
phospholipase C-activating G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of G-protein coupled receptor protein signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
Names
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1
PLC-epsilon-1
phosphoinositide phospholipase C-epsilon-1
phospholipase C-epsilon-1
NP_062534.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019588.2NP_062534.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

    See identical proteins and their annotated locations for NP_062534.2

    Status: VALIDATED

    Source sequence(s)
    AB076247, AC158905, AK122521, AK162236, BF466343, CD803532, CF537630, CN535034
    Consensus CDS
    CCDS37973.1
    UniProtKB/Swiss-Prot
    Q8K4S1
    Related
    ENSMUSP00000130604, OTTMUSP00000063603, ENSMUST00000169713, OTTMUST00000113855
    Conserved Domains (6) summary
    cd00275
    Location:18481964
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd01780
    Location:21172216
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:13721813
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:12991963
    PLN02952; phosphoinositide phospholipase C
    cl02485
    Location:528826
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cl08538
    Location:13091360
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p3 C57BL/6J

    Range
    38481114..38785105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247378.1XP_011245680.1  

    See identical proteins and their annotated locations for XP_011245680.1

    Conserved Domains (6) summary
    cd00275
    Location:18641980
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd01780
    Location:21332232
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:13881829
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:13151979
    PLN02952; phosphoinositide phospholipase C
    cl02485
    Location:528826
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cl08538
    Location:13251376
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
  2. XM_011247379.1XP_011245681.1  

    See identical proteins and their annotated locations for XP_011245681.1

    Conserved Domains (6) summary
    cd00275
    Location:18641980
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd01780
    Location:21332232
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:13881829
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:13151979
    PLN02952; phosphoinositide phospholipase C
    cl02485
    Location:528826
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cl08538
    Location:13251376
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
  3. XM_006527394.2XP_006527457.1  

    See identical proteins and their annotated locations for XP_006527457.1

    Conserved Domains (6) summary
    cd00275
    Location:18641980
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd01780
    Location:21332232
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:13881829
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:13151979
    PLN02952; phosphoinositide phospholipase C
    cl02485
    Location:528826
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cl08538
    Location:13251376
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
  4. XM_011247380.1XP_011245682.1  

    See identical proteins and their annotated locations for XP_011245682.1

    UniProtKB/Swiss-Prot
    Q8K4S1
    Related
    ENSMUSP00000138360, OTTMUSP00000063608, ENSMUST00000182481, OTTMUST00000113863
    Conserved Domains (6) summary
    cd00275
    Location:18481964
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd01780
    Location:21172216
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:13721813
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:12991963
    PLN02952; phosphoinositide phospholipase C
    cl02485
    Location:528826
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cl08538
    Location:13091360
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
  5. XM_006527395.2XP_006527458.1  

    Conserved Domains (6) summary
    cd00275
    Location:14831599
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd01780
    Location:17521851
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:10071448
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:9341598
    PLN02952; phosphoinositide phospholipase C
    pfam00617
    Location:148329
    RasGEF; RasGEF domain
    cl08538
    Location:944995
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

Alternate Mm_Celera

Genomic

  1. AC_000041.1 Alternate Mm_Celera

    Range
    39314226..39575892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)