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Irak3 interleukin-1 receptor-associated kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 73914, updated on 22-May-2016
Official Symbol
Irak3provided by MGI
Official Full Name
interleukin-1 receptor-associated kinase 3provided by MGI
Primary source
MGI:MGI:1921164
See related
Ensembl:ENSMUSG00000020227 Vega:OTTMUSG00000034096
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IRAK-M; AI563835; 4833428C18Rik
Orthologs
Location:
10; 10 D2
Exon count:
14
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (120141648..120201597, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (119578710..119638593, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene glutamate receptor interacting protein 1 Neighboring gene glutamate receptor interacting protein 1, opposite strand 1 Neighboring gene helicase (DNA) B Neighboring gene predicted gene, 34545 Neighboring gene predicted gene, 40781 Neighboring gene predicted gene, 38500 Neighboring gene predicted gene, 40782 Neighboring gene transmembrane BAX inhibitor motif containing 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-1-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cytokine-mediated signaling pathway IC
Inferred by Curator
more info
PubMed 
negative regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein complex disassembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of macrophage tolerance induction IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
regulation of protein complex disassembly IDA
Inferred from Direct Assay
more info
PubMed 
response to exogenous dsRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to peptidoglycan IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to virus IC
Inferred by Curator
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
interleukin-1 receptor-associated kinase 3
Names
IL-1 receptor-associated kinase M
IRAK-3
irak3
NP_082955.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028679.3NP_082955.2  interleukin-1 receptor-associated kinase 3

    See identical proteins and their annotated locations for NP_082955.2

    Status: PROVISIONAL

    Source sequence(s)
    AK029057
    Consensus CDS
    CCDS24204.1
    UniProtKB/Swiss-Prot
    Q8K4B2
    UniProtKB/TrEMBL
    Q0VB14
    Related
    ENSMUSP00000020448, OTTMUSP00000046651, ENSMUST00000020448, OTTMUST00000086213
    Conserved Domains (3) summary
    pfam00069
    Location:178455
    Pkinase; Protein kinase domain
    cd08796
    Location:16102
    Death_IRAK-M; Death domain of Interleukin 1 Receptor Associated Kinase-M
    cd14160
    Location:184459
    PK_IRAK3; Pseudokinase domain of Interleukin-1 Receptor Associated Kinase 3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

    Range
    120141648..120201597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514228.2XP_006514291.1  

    See identical proteins and their annotated locations for XP_006514291.1

    Conserved Domains (1) summary
    cl21453
    Location:1247
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006514227.2XP_006514290.1  

    See identical proteins and their annotated locations for XP_006514290.1

    Conserved Domains (1) summary
    cl21453
    Location:1247
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_380448.1 RNA Sequence

    Related
    ENSMUST00000135106, OTTMUST00000086216

Alternate Mm_Celera

Genomic

  1. AC_000032.1 Alternate Mm_Celera

    Range
    122502683..122562840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)