Format

Send to:

Choose Destination

COL14A1 collagen type XIV alpha 1 [ Homo sapiens (human) ]

Gene ID: 7373, updated on 8-May-2016
Official Symbol
COL14A1provided by HGNC
Official Full Name
collagen type XIV alpha 1provided by HGNC
Primary source
HGNC:HGNC:2191
See related
Ensembl:ENSG00000187955 HPRD:00379; MIM:120324; Vega:OTTHUMG00000149877
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UND
Summary
This gene encodes the alpha chain of type XIV collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XIV collagen interacts with the fibril surface and is involved in the regulation of fibrillogenesis. [provided by RefSeq, Jan 2013]
Orthologs
Location:
8q23
Exon count:
50
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (120125108..120373573)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (121137347..121384273)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 277 Neighboring gene DEP domain containing MTOR-interacting protein Neighboring gene uncharacterized LOC105375730 Neighboring gene uncharacterized LOC105375729 Neighboring gene mitochondrial ribosomal protein L13 Neighboring gene MDM2 binding protein Neighboring gene syntrophin beta 1 Neighboring gene non-SMC condensin I complex subunit G pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Epidemiological and genome-wide association study of gastritis or gastric ulcer in korean populations.
NHGRI GWA Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog
  • Collagen biosynthesis and modifying enzymes, organism-specific biosystem (from REACTOME)
    Collagen biosynthesis and modifying enzymes, organism-specific biosystemThe biosynthesis of collagen is a multistep process. Collagen propeptides are cotranslationally translocated into the ER lumen. Propeptides undergo a number of post-translational modifications. Proli...
  • Collagen degradation, organism-specific biosystem (from REACTOME)
    Collagen degradation, organism-specific biosystemCollagen fibril diameter and spatial organisation are dependent on the species, tissue type and stage of development (Parry 1988). The lengths of collagen fibrils in mature tissues are largely unknow...
  • Collagen formation, organism-specific biosystem (from REACTOME)
    Collagen formation, organism-specific biosystemCollagen is a family of at least 29 structural proteins derived from over 40 human genes (Myllyharju & Kivirikko 2004). It is the main component of connective tissue, and the most abundant protein in...
  • Degradation of the extracellular matrix, organism-specific biosystem (from REACTOME)
    Degradation of the extracellular matrix, organism-specific biosystemMatrix metalloproteinases (MMPs), previously referred to as matrixins because of their role in degradation of the extracellular matrix (ECM), are zinc and calcium dependent proteases belonging to the...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
  • Protein digestion and absorption, organism-specific biosystem (from KEGG)
    Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
  • Protein digestion and absorption, conserved biosystem (from KEGG)
    Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
collagen binding NAS
Non-traceable Author Statement
more info
PubMed 
extracellular matrix structural constituent NAS
Non-traceable Author Statement
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding, bridging NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
collagen fibril organization NAS
Non-traceable Author Statement
more info
PubMed 
extracellular matrix organization NAS
Non-traceable Author Statement
more info
PubMed 
single organismal cell-cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
collagen trimer NAS
Non-traceable Author Statement
more info
PubMed 
collagen type XIV trimer NAS
Non-traceable Author Statement
more info
PubMed 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
proteinaceous extracellular matrix NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
collagen alpha-1(XIV) chain
Names
undulin (fibronectin-tenascin-related)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033107.1 RefSeqGene

    Range
    5001..253468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021110.3NP_066933.1  collagen alpha-1(XIV) chain precursor

    See identical proteins and their annotated locations for NP_066933.1

    Status: REVIEWED

    Source sequence(s)
    AC107877, AK307716, BC140893, CF529353, DA373565, DB286127
    Consensus CDS
    CCDS34938.1
    UniProtKB/Swiss-Prot
    Q05707
    Related
    ENSP00000297848, OTTHUMP00000194886, ENST00000297848, OTTHUMT00000313657
    Conserved Domains (5) summary
    pfam01391
    Location:14781553
    Collagen; Collagen triple helix repeat (20 copies)
    smart00060
    Location:739817
    FN3; Fibronectin type 3 domain
    smart00210
    Location:12291424
    TSPN; Thrombospondin N-terminal -like domains
    cd00063
    Location:536621
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd01482
    Location:10311195
    vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    120125108..120373573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251059.2XP_005251116.1  

    UniProtKB/Swiss-Prot
    Q05707
    Related
    ENSP00000311809, OTTHUMP00000194889, ENST00000309791, OTTHUMT00000313659
    Conserved Domains (5) summary
    pfam01391
    Location:14781553
    Collagen; Collagen triple helix repeat (20 copies)
    smart00060
    Location:739817
    FN3; Fibronectin type 3 domain
    smart00210
    Location:12291424
    TSPN; Thrombospondin N-terminal -like domains
    cd00063
    Location:536621
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd01482
    Location:10311195
    vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...
  2. XM_006716651.2XP_006716714.1  

    See identical proteins and their annotated locations for XP_006716714.1

    UniProtKB/Swiss-Prot
    Q05707
    Conserved Domains (5) summary
    pfam01391
    Location:14781553
    Collagen; Collagen triple helix repeat (20 copies)
    smart00060
    Location:739817
    FN3; Fibronectin type 3 domain
    smart00210
    Location:12291424
    TSPN; Thrombospondin N-terminal -like domains
    cd00063
    Location:536621
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd01482
    Location:10311195
    vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    121177769..121424764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)