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UMPS uridine monophosphate synthetase [ Homo sapiens (human) ]

Gene ID: 7372, updated on 18-Oct-2014
Official Symbol
UMPSprovided by HGNC
Official Full Name
uridine monophosphate synthetaseprovided by HGNC
Primary source
HGNC:HGNC:12563
Locus tag
OK/SW-cl.21
See related
HPRD:02022; MIM:613891
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OPRT
Summary
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
See UMPS in Epigenomics, MapViewer
Location:
3q13
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 3 NC_000003.12 (124730366..124749273)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (124449213..124468120)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene kalirin, RhoGEF kinase Neighboring gene microRNA 6083 Neighboring gene mediator of cell motility 1 pseudogene Neighboring gene ribosomal protein S26 pseudogene 22 Neighboring gene microRNA 544b Neighboring gene integrin, beta 5 Neighboring gene enolase 1, (alpha) pseudogene 3 Neighboring gene mucin 13, cell surface associated

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of uridine monophosphate synthetase (UMPS) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
'de novo' UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
UMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to drug IEA
Inferred from Electronic Annotation
more info
 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
lactation IEA
Inferred from Electronic Annotation
more info
 
nucleobase-containing small molecule metabolic process TAS
Traceable Author Statement
more info
 
pyrimidine nucleobase metabolic process TAS
Traceable Author Statement
more info
 
pyrimidine nucleoside biosynthetic process TAS
Traceable Author Statement
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
uridine 5'-monophosphate synthase
Names
uridine 5'-monophosphate synthase
OPRTase
OMPdecase
UMP synthase
orotate phosphoribosyltransferase
orotidine 5'-phosphate decarboxylase
NP_000364.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017037.1 

    Range
    5001..23908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000373.3NP_000364.1  uridine 5'-monophosphate synthase

    See proteins identical to NP_000364.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC022336, BC007511
    Consensus CDS
    CCDS3029.1
    UniProtKB/TrEMBL
    A8K5J1
    UniProtKB/Swiss-Prot
    P11172
    Conserved Domains (2) summary
    cd06223
    Location:53175
    PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain
    cd04725
    Location:254466
    OMP_decarboxylase_like; Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase ...

RNA

  1. NR_033434.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC022336, EU921887
  2. NR_033437.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC022336, EU921891

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000003.12 

    Range
    124730366..124749273
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000135.1 

    Range
    121823485..121842386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 

    Range
    124412201..124431088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)