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UGT2B15 UDP glucuronosyltransferase family 2 member B15 [ Homo sapiens (human) ]

Gene ID: 7366, updated on 8-May-2016
Official Symbol
UGT2B15provided by HGNC
Official Full Name
UDP glucuronosyltransferase family 2 member B15provided by HGNC
Primary source
HGNC:HGNC:12546
See related
Ensembl:ENSG00000196620 HPRD:07192; MIM:600069; Vega:OTTHUMG00000161507
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HLUG4; UGT2B8; UDPGTH3; UDPGT 2B8; UDPGT2B15
Summary
This gene encodes a member of the UDP-glycosyltransferase (UDPGT) family. The UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein displays activity towards several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens. [provided by RefSeq, Oct 2011]
Orthologs
Location:
4q13
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (68646597..68670776, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (69512315..69536494, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene UBX domain protein 2A pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member B15 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member B15 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member A3 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT retinoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular glucuronidation IDA
Inferred from Direct Assay
more info
PubMed 
flavonoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
flavonoid glucuronidation IBA
Inferred from Biological aspect of Ancestor
more info
 
steroid metabolic process TAS
Traceable Author Statement
more info
PubMed 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
UDP-glucuronosyltransferase 2B15
Names
UDP glucuronosyltransferase 2 family, polypeptide B15
UDP glycosyltransferase 2B15
UDP-glucuronosyltransferase 2B8
UDP-glucuronosyltransferase UGT2B15
UDP-glucuronyltransferase, family 2, beta-15
UDPGT 2B15
UDPGTh-3
NP_001067.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076.3NP_001067.2  UDP-glucuronosyltransferase 2B15 precursor

    See identical proteins and their annotated locations for NP_001067.2

    Status: REVIEWED

    Source sequence(s)
    AF180322, BC171879, U06641
    Consensus CDS
    CCDS3524.1
    UniProtKB/Swiss-Prot
    P54855
    UniProtKB/TrEMBL
    B7ZW53
    Related
    ENSP00000341045, OTTHUMP00000220326, ENST00000338206, OTTHUMT00000365172
    Conserved Domains (2) summary
    cd03784
    Location:45449
    GT1_Gtf_like; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the ...
    pfam00201
    Location:24518
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    68646597..68670776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_1

Genomic

  1. NT_167250.2 Reference GRCh38.p2 ALT_REF_LOCI_1

    Range
    222964..247131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    69549031..69573207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)