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UGP2 UDP-glucose pyrophosphorylase 2 [ Homo sapiens (human) ]

Gene ID: 7360, updated on 29-Jul-2014
Official Symbol
UGP2provided by HGNC
Official Full Name
UDP-glucose pyrophosphorylase 2provided by HGNC
Primary source
HGNC:12527
See related
Ensembl:ENSG00000169764; HPRD:08934; MIM:191760; Vega:OTTHUMG00000129513
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UDPG; UGP1; UDPGP; UGPP1; UGPP2; UDPGP2; pHC379
Summary
The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
See UGP2 in Epigenomics, MapViewer
Location:
2p14-p13
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 2 NC_000002.12 (63840950..63891562)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (64068084..64118696)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene citrate synthase pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 66 Neighboring gene vacuolar protein sorting 54 homolog (S. cerevisiae) Neighboring gene pellino E3 ubiquitin protein ligase 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
UTP:glucose-1-phosphate uridylyltransferase activity EXP
Inferred from Experiment
more info
 
UTP:glucose-1-phosphate uridylyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
glucose binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
pyrimidine ribonucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
UDP-glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
UDP-glucuronate biosynthetic process TAS
Traceable Author Statement
more info
 
carbohydrate metabolic process TAS
Traceable Author Statement
more info
 
cellular glucuronidation TAS
Traceable Author Statement
more info
 
glucose 1-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 
glucose metabolic process TAS
Traceable Author Statement
more info
 
glycogen biosynthetic process TAS
Traceable Author Statement
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
UTP--glucose-1-phosphate uridylyltransferase
Names
UTP--glucose-1-phosphate uridylyltransferase
UGPase 2
UDP-glucose diphosphorylase
UDP-glucose pyrophosphorylase 1
UTP-glucose-1-phosphate uridyltransferase
UTP--glucose-1-phosphate uridylyltransferase 2
Uridyl diphosphate glucose pyrophosphorylase-1
uridyl diphosphate glucose pyrophosphorylase 2
NP_001001521.1
NP_006750.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001521.1NP_001001521.1  UTP--glucose-1-phosphate uridylyltransferase isoform b

    See proteins identical to NP_001001521.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    BC002954, CD516624
    Consensus CDS
    CCDS42690.1
    UniProtKB/Swiss-Prot
    Q16851
    Related
    ENSP00000377939, OTTHUMP00000214361, ENST00000394417, OTTHUMT00000353858
    Conserved Domains (1) summary
    cd00897
    Location:94400
    Blast Score: 1582
    UGPase_euk; Eukaryotic UGPase catalyses the synthesis of UDP-Glucose
  2. NM_006759.3NP_006750.3  UTP--glucose-1-phosphate uridylyltransferase isoform a

    See proteins identical to NP_006750.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC000173, BC002954, CA389301
    Consensus CDS
    CCDS1875.1
    UniProtKB/Swiss-Prot
    Q16851
    Related
    ENSP00000338703, OTTHUMP00000159899, ENST00000337130, OTTHUMT00000251688
    Conserved Domains (1) summary
    cd00897
    Location:105411
    Blast Score: 1583
    UGPase_euk; Eukaryotic UGPase catalyses the synthesis of UDP-Glucose

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000002.12 

    Range
    63840950..63891562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264538.1XP_005264595.1  

    See proteins identical to XP_005264595.1

    UniProtKB/Swiss-Prot
    Q16851
    Related
    ENSP00000420793, OTTHUMP00000214363, ENST00000467648, OTTHUMT00000353861
    Conserved Domains (1) summary
    cd00897
    Location:94400
    Blast Score: 1582
    UGPase_euk; Eukaryotic UGPase catalyses the synthesis of UDP-Glucose
  2. XM_006712088.1XP_006712151.1  

    See proteins identical to XP_006712151.1

    Conserved Domains (1) summary
    cd00897
    Location:1291
    Blast Score: 1481
    UGPase_euk; Eukaryotic UGPase catalyses the synthesis of UDP-Glucose
  3. XM_005264537.2XP_005264594.1  

    See proteins identical to XP_005264594.1

    UniProtKB/Swiss-Prot
    Q16851
    Conserved Domains (1) summary
    cd00897
    Location:94400
    Blast Score: 1582
    UGPase_euk; Eukaryotic UGPase catalyses the synthesis of UDP-Glucose
  4. XM_006712089.1XP_006712152.1  

    See proteins identical to XP_006712152.1

    Conserved Domains (1) summary
    cd00897
    Location:1291
    Blast Score: 1481
    UGPase_euk; Eukaryotic UGPase catalyses the synthesis of UDP-Glucose

RNA

  1. XR_426996.1 RNA Sequence

Alternate HuRef

Genomic

  1. AC_000134.1 

    Range
    63807585..63858409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 

    Range
    63998438..64048971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)