HPRT1 hypoxanthine phosphoribosyltransferase 1 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: HPRT1provided by VGNC
Official Full Name: hypoxanthine phosphoribosyltransferase 1provided by VGNC
Primary source: VGNC:VGNC:55715
Locus tag: CK820_G0044829
See related: Ensembl:ENSPTRG00000022287
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: X

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	X	NC_072421.2 (131932773..131973644)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	X	NC_072421.1 (131928842..131969713)

Chromosome X - NC_072421.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

G67215 (e-PCR)
- UniSTS:186368

Hprt (e-PCR), detects polymorphism
- UniSTS:265222

G42837 (e-PCR)
- UniSTS:94746

PMC313988P1 (e-PCR)
- UniSTS:272927

HPRT (e-PCR)
- UniSTS:99359

PMC313988P2 (e-PCR)
- UniSTS:272928

STS-V00530 (e-PCR)
- UniSTS:8754

GDB:185506 (e-PCR)
- UniSTS:155452

HPRT1_1621 (e-PCR)
- UniSTS:277325

GDB:181411 (e-PCR)
- UniSTS:155241

GDB:192504 (e-PCR)
- UniSTS:98989

STS-N33128 (e-PCR)
- UniSTS:6845

DXS909 (e-PCR)
- UniSTS:147155

GDB:190000 (e-PCR)
- UniSTS:155604

GDB:371809 (e-PCR)
- UniSTS:156889

DXS10107A8 (e-PCR)
- UniSTS:477404

PMC22513P1 (e-PCR)
- UniSTS:272116

GDB:177372 (e-PCR)
- UniSTS:154869

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables hypoxanthine phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in GMP salvage	IEA Inferred from Electronic Annotation more info	PubMed
involved_in IMP salvage	IEA Inferred from Electronic Annotation more info	PubMed
involved_in guanine salvage	IEA Inferred from Electronic Annotation more info	PubMed
involved_in hypoxanthine metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in purine ribonucleoside salvage	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: hypoxanthine-guanine phosphoribosyltransferase

Names: HGPRT; HGPRTase; hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome)

NP_001104287.1

EC 2.4.2.8

XP_016798152.1

EC 2.4.2.8

XP_016798153.1

EC 2.4.2.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110817.1 → NP_001104287.1 hypoxanthine-guanine phosphoribosyltransferase

See identical proteins and their annotated locations for NP_001104287.1

Status: PROVISIONAL

Source sequence(s)

AB222109

UniProtKB/Swiss-Prot

A5A6I1

UniProtKB/TrEMBL

A0A2I3SAZ9

Related

ENSPTRP00000086770.1, ENSPTRT00000092477.1

Conserved Domains (1) summary

cl00309
Location:8 → 218

PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072421.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

131932773..131973644

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_016942663.3 → XP_016798152.1 hypoxanthine-guanine phosphoribosyltransferase isoform X1

UniProtKB/TrEMBL

A0A2I3SAZ9

Conserved Domains (1) summary

cl00309
Location:32 → 250

PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain
XM_016942664.2 → XP_016798153.1 hypoxanthine-guanine phosphoribosyltransferase isoform X2

UniProtKB/TrEMBL

H2QZ50

Related

ENSPTRP00000038394.6