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UBP1 upstream binding protein 1 (LBP-1a) [ Homo sapiens (human) ]

Gene ID: 7342, updated on 8-May-2016
Official Symbol
UBP1provided by HGNC
Official Full Name
upstream binding protein 1 (LBP-1a)provided by HGNC
Primary source
HGNC:HGNC:12507
See related
Ensembl:ENSG00000153560 HPRD:10291; MIM:609784; Vega:OTTHUMG00000130749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LBP1A; LBP1B; LBP-1B; LBP-1a
Orthologs
Location:
3p22.3
Exon count:
19
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (33388336..33440813, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (33429828..33481897, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene cartilage associated protein Neighboring gene sushi domain containing 5 Neighboring gene F-box and leucine-rich repeat protein 2 Neighboring gene RNA, 5S ribosomal pseudogene 128 Neighboring gene cytoplasmic linker associated protein 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat Combination of LBP-1 and Oct1 cellular transcription activators represses transcription initiation at the HIV-1 LTR promoter by HIV-1 Tat PubMed
tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation, is suppressed by HIV-1 Tat PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp686L1745

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
transcription factor activity, sequence-specific DNA binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
viral genome replication TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
upstream-binding protein 1
Names
transcription factor LBP-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128160.1NP_001121632.1  upstream-binding protein 1 isoform LBP-1a

    See identical proteins and their annotated locations for NP_001121632.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the mid-coding region compared to variant 1. The resulting isoform (LBP-1a) is shorter than isoform a.
    Source sequence(s)
    AK023274, AL831847, BC047235
    Consensus CDS
    CCDS46788.1
    UniProtKB/Swiss-Prot
    Q9NZI7
    UniProtKB/TrEMBL
    A0A024R2J0
    Related
    ENSP00000395558, OTTHUMP00000209005, ENST00000447368, OTTHUMT00000342561
    Conserved Domains (2) summary
    cd09588
    Location:333399
    SAM_LBP1; SAM domain of LBP1 (UBP1) transcription factors
    pfam04516
    Location:34259
    CP2; CP2 transcription factor
  2. NM_001128161.1NP_001121633.1  upstream-binding protein 1 isoform LBP-1b

    See identical proteins and their annotated locations for NP_001121633.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (LBP-1b).
    Source sequence(s)
    AK293100, AL831847, BC047235, DB131031
    Consensus CDS
    CCDS2659.1
    UniProtKB/Swiss-Prot
    Q9NZI7
    UniProtKB/TrEMBL
    A0A024R2L0, A8KAN5
    Related
    ENSP00000283628, OTTHUMP00000209006, ENST00000283628, OTTHUMT00000342562
    Conserved Domains (2) summary
    cd09588
    Location:369435
    SAM_LBP1; SAM domain of LBP1 (UBP1) transcription factors
    pfam04516
    Location:34259
    CP2; CP2 transcription factor
  3. NM_014517.4NP_055332.3  upstream-binding protein 1 isoform LBP-1b

    See identical proteins and their annotated locations for NP_055332.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (LBP-1b). Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AF198487, AK023274, AL831847, BC047235
    Consensus CDS
    CCDS2659.1
    UniProtKB/Swiss-Prot
    Q9NZI7
    UniProtKB/TrEMBL
    A0A024R2L0
    Related
    ENSP00000283629, OTTHUMP00000161314, ENST00000283629, OTTHUMT00000253249
    Conserved Domains (2) summary
    cd09588
    Location:369435
    SAM_LBP1; SAM domain of LBP1 (UBP1) transcription factors
    pfam04516
    Location:34259
    CP2; CP2 transcription factor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    33388336..33440813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534077.1XP_011532379.1  

    Conserved Domains (2) summary
    cd09588
    Location:336402
    SAM_LBP1; SAM domain of LBP1 (UBP1) transcription factors
    pfam04516
    Location:41262
    CP2; CP2 transcription factor

RNA

  1. XR_940498.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    33379810..33431856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)