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UBE2I ubiquitin-conjugating enzyme E2I [ Homo sapiens (human) ]

Gene ID: 7329, updated on 27-Apr-2015
Official Symbol
UBE2Iprovided by HGNC
Official Full Name
ubiquitin-conjugating enzyme E2Iprovided by HGNC
Primary source
HGNC:HGNC:12485
See related
Ensembl:ENSG00000103275; HPRD:09045; MIM:601661; Vega:OTTHUMG00000186701
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P18; UBC9; C358B7.1
Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
See UBE2I in MapViewer
Location:
16p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (1309153..1327018)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1357420..1377019)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene tryptase pseudogene 1 Neighboring gene tryptase pseudogene 2 Neighboring gene ribosomal protein S20 pseudogene 2 Neighboring gene BAI1-associated protein 3 Neighboring gene TSR3, 20S rRNA accumulation, homolog (S. cerevisiae)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Levels of HIV-1 gp120 and Endo Hf-resistant gp120 are reduced in the absence of UBC9 expression. Degradation of gp120 occurs before transport to the plasma membrane and the lipid rafts in the UBC9 knockdown cells PubMed
env UBC9 contributes to viral glycoproteins gp120/gp41 stability in the presence of Gag expression and affects incorporation of the gp120/gp41 into virions PubMed
Envelope transmembrane glycoprotein gp41 env UBC9 contributes to viral glycoproteins gp120/gp41 stability in the presence of Gag expression and affects incorporation of the gp120/gp41 into released virions PubMed
Pr55(Gag) gag HIV-1 Gag trafficking and association with the plasma membrane is altered in the absebce of UBC9 PubMed
gag UBC9 contributes to viral glycoproteins gp120/gp41 stability in the presence of Gag expression and affects incorporation of the gp120/gp41 into released virions PubMed
gag Disrupting the function of KIF4 leads Gag transient accumulation in discrete, perinuclear, nonendocytic clusters that co-localize with endogenous KIF4, Ubc9, and SUMO PubMed
gag Coimmunoprecipitation shows that HIV-1 Gag and human UBC9 interact in vivo. HIV-1 Gag and human UBC9 colocalize in HIV-1-expressing cells PubMed
integrase gag-pol HIV-1 IN interacts with SUMO1/SUMO2 and Ubc9 in cells. Upregulations of SUMO1/SUMO2 and Ubc9 inhibit HIV-1 integration, while downregulations of SUMO1/SUMO2 and Ubc9 increase HIV-1 integration PubMed
p6 gag HIV-1 p6 interacts with Ubc9 in a yeast two-hybrid system PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
HLH domain binding IEA
Inferred from Electronic Annotation
more info
 
RING-like zinc finger domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
SUMO conjugating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
SUMO transferase activity EXP
Inferred from Experiment
more info
 
bHLH transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of SUMO transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of intracellular steroid hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
protein sumoylation IEA
Inferred from Electronic Annotation
more info
 
protein sumoylation TAS
Traceable Author Statement
more info
 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of receptor activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PML body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
fibrillar center IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
sumoylated E2 ligase complex IC
Inferred by Curator
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 
synaptonemal complex TAS
Traceable Author Statement
more info
PubMed 
transferase complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
SUMO-conjugating enzyme UBC9
Names
SUMO-conjugating enzyme UBC9
SUMO-1-protein ligase
SUMO-protein ligase
ubiquitin carrier protein 9
ubiquitin carrier protein I
ubiquitin conjugating enzyme 9
ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9)
ubiquitin-conjugating enzyme UbcE2A
ubiquitin-like protein SUMO-1 conjugating enzyme
ubiquitin-protein ligase E2I
ubiquitin-protein ligase I
NP_003336.1
NP_919235.1
NP_919236.1
NP_919237.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003345.4NP_003336.1  SUMO-conjugating enzyme UBC9

    See identical proteins and their annotated locations for NP_003336.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK291118, AL031714, BC000427, BG530957, BI793063
    Consensus CDS
    CCDS10433.1
    UniProtKB/TrEMBL
    A8K503
    UniProtKB/Swiss-Prot
    P63279
    Related
    ENSP00000380649, OTTHUMP00000045512, ENST00000397514, OTTHUMT00000109068
    Conserved Domains (2) summary
    COG5078
    Location:1156
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:7152
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  2. NM_194259.2NP_919235.1  SUMO-conjugating enzyme UBC9

    See identical proteins and their annotated locations for NP_919235.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional exon in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AK291118, AL031714, BF315618, BG530957, BI793063, D45050
    Consensus CDS
    CCDS10433.1
    UniProtKB/TrEMBL
    A8K503
    UniProtKB/Swiss-Prot
    P63279
    Related
    ENSP00000380650, OTTHUMP00000158629, ENST00000397515, OTTHUMT00000250319
    Conserved Domains (2) summary
    COG5078
    Location:1156
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:7152
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  3. NM_194260.2NP_919236.1  SUMO-conjugating enzyme UBC9

    See identical proteins and their annotated locations for NP_919236.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AC120498, AL031714, BI793063, CX788607
    Consensus CDS
    CCDS10433.1
    UniProtKB/Swiss-Prot
    P63279
    Related
    ENSP00000348056, OTTHUMP00000158627, ENST00000355803, OTTHUMT00000250317
    Conserved Domains (2) summary
    COG5078
    Location:1156
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:7152
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  4. NM_194261.2NP_919237.1  SUMO-conjugating enzyme UBC9

    See identical proteins and their annotated locations for NP_919237.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AB208988, AC120498, AL031714, BI793063
    Consensus CDS
    CCDS10433.1
    UniProtKB/Swiss-Prot
    P63279
    Related
    ENSP00000324897, OTTHUMP00000158628, ENST00000325437, OTTHUMT00000250318
    Conserved Domains (2) summary
    COG5078
    Location:1156
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:7152
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    1309153..1327018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522645.1XP_011520947.1  

    See identical proteins and their annotated locations for XP_011520947.1

    Conserved Domains (2) summary
    COG5078
    Location:1137
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:7137
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  2. XM_005255540.2XP_005255597.1  

    See identical proteins and their annotated locations for XP_005255597.1

    UniProtKB/TrEMBL
    B0QYN7
    Conserved Domains (2) summary
    COG5078
    Location:1137
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:7137
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  3. XM_011522644.1XP_011520946.1  

    See identical proteins and their annotated locations for XP_011520946.1

    Conserved Domains (2) summary
    COG5078
    Location:1137
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:7137
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  4. XM_005255541.3XP_005255598.1  

    See identical proteins and their annotated locations for XP_005255598.1

    UniProtKB/TrEMBL
    B0QYN7
    Conserved Domains (2) summary
    COG5078
    Location:1137
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    cd00195
    Location:7137
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    1359074..1376964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)