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    UBE2I ubiquitin-conjugating enzyme E2I [ Homo sapiens ]

    Gene ID: 7329, updated on 19-May-2012
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    Summary

    Official Symbol
    UBE2Iprovided by HGNC
    Official Full Name
    ubiquitin-conjugating enzyme E2Iprovided by HGNC
    Primary source
    HGNC:12485
    See related
    Ensembl:ENSG00000103275; HPRD:09045; MIM:601661; Vega:OTTHUMG00000047845
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P18; UBC9; C358B7.1
    Summary
    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    16p13.3
    Sequence :
    Chromosome: 16; NC_000016.9 (1359180..1375390)
    See UBE2I in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene tryptase pseudogene 1 Neighboring gene tryptase pseudogene 2 Neighboring gene ribosomal protein S20 pseudogene 2 Neighboring gene BAI1-associated protein 3 Neighboring gene chromosome 16 open reading frame 42

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. GLUT4 and UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance. Kampmann U, et al. PLoS One, 2011. PMID 22114711.
    2. Correlations among ERCC1, XPB, UBE2I, EGF, TAL2 and ILF3 revealed by gene signatures of histological subtypes of patients with epithelial ovarian cancer. Guo Y, et al. Oncol Rep, 2012 Jan. PMID 21971700.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators. García-Gutiérrez P, et al. EMBO Rep, 2011 Sep 30. PMID 21836637.

    See all (218) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance.
      Title: GLUT4 and UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance.
    2. There was no statistical association of UBE2I expression between human epithelial ovarian cancer tumor and normal tissues
      Title: Correlations among ERCC1, XPB, UBE2I, EGF, TAL2 and ILF3 revealed by gene signatures of histological subtypes of patients with epithelial ovarian cancer.
    3. Ubc9 and PIAS1 potentiated SF-1-mediated transactivation of human CYP17, CYP11A1, and CYP11B1 but not CYP11B2 promoters.
      Title: Coactivation of SF-1-mediated transcription of steroidogenic enzymes by Ubc9 and PIAS1.
    4. Binding of BRCA1 proteins to nuclear chaperone Ubc9 provides a novel mechanism for nuclear import and control of tumor growth.
      Title: Ubc9 mediates nuclear localization and growth suppression of BRCA1 and BRCA1a proteins.
    5. The authors propose that LMP1, by interaction with Ubc9, modulates sumoylation processes, which regulate signal transduction pathways that affect phenotypic changes associated with oncogenesis.
      Title: Epstein-Barr virus latent membrane protein 1 (LMP1) C-terminal-activating region 3 contributes to LMP1-mediated cellular migration via its interaction with Ubc9.
    6. The authors report that the high risk human papillomavirus E6 proteins reduce the intracellular quantity of the sole SUMO conjugation enzyme, Ubc9, concomitant with decreased host sumoylation.
      Title: HPV E6 proteins target Ubc9, the SUMO conjugating enzyme.
    7. Analysis of the dynamics of E2(Ubc9)-SUMO-Target(RanGAP1) in the absence and presence of E3(RanBP2) revealed that two different allosteric sites regulate the ligase activity.
      Title: Alternative allosteric mechanisms can regulate the substrate and E2 in SUMO conjugation.
    8. In this study they compared nIGF-1R accumulation in neoplastic and normal cells in relation to expression of IGF-1R and Ubc9.
      Title: Over-accumulation of nuclear IGF-1 receptor in tumor cells requires elevated expression of the receptor and the SUMO-conjugating enzyme Ubc9.
    9. the c.73G>A polymorphism of the UBC9 gene may affect DNA DSBs repair efficacy in breast cancer patients
      Title: Efficacy of DNA double-strand breaks repair in breast cancer is decreased in carriers of the variant allele of the UBC9 gene c.73G>A polymorphism.
    10. The authors demonstrate that NS1 of the highly pathogenic avian influenza A/Duck/Hubei/L-1/2004 (H5N1) virus interacts with human Ubc9 and SUMO1 is conjugated to H5N1 NS1 in both transfected and infected cells.
      Title: Modification of nonstructural protein 1 of influenza A virus by SUMO1.
    Submit: New GeneRIF Correction See all (64)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    p6 gag HIV-1 p6 interacts with Ubc9 in a yeast two-hybrid system PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_003336.1 AAB80718.1 CBX4    BIND  PubMed Ubc9 interacts with Pc2. 
    NP_003336.1 AAC51130.1 CEBPE    BIND  PubMed C/EBP-epsilon interacts with UBE2I. 
    NP_003336.1 AAB87383.1 CHD3    BIND  PubMed Ubc9 interacts with CHD3. 
    NP_003336.1 NP_001341.1 DAXX    BIND  PubMed Daxx interacts with Ubc9. 
    NP_003336.1 NP_008823.1 DNMT3B    BIND  PubMed Dnmt3b interacts with Ubc9. 
    NP_003336.1 NP_041327.1 E1    BIND  PubMed HPV16 E1 interacts with hUBC9. 
    NP_003336.1 NP_073577.2 HIPK2    BIND  PubMed Ubc9 with HIPK2. 
    NP_003336.1 NP_941977.1 HTNVsSgp1    BIND  PubMed Hantaan virus nucleocapsid protein interacts with Ubc9. 
    NP_003336.1 NP_002236.1 KCNK1    BIND  PubMed K2P1 interacts with Ubc-9. 
    NP_003336.1 NP_057250.1 PIAS1    BIND  PubMed Ubc9 interacts with PIAS1. 
    NP_003336.1 NP_004662.1 PIAS2    BIND  PubMed Ubc9 interacts with PIASxb-eta. 
    NP_003336.1 NP_006258.2 RANBP2    BIND  PubMed RanBP2 interacts with Ubc9. 
    NP_003336.1 NP_002959.1 SALL1    BIND  PubMed SALL1 interacts with UBE2I. 
    NP_003336.1 NP_003022.2 SIAH1    BIND  PubMed Ubc9 interacts with Siah-1. 
    NP_003336.1 NP_003022.2 SIAH1    BIND  PubMed hSiah1 interacts with Ubc9. 
    NP_003336.1 NP_005058.3 SIAH2    BIND  PubMed Ubc9 interacts with Siah-2. 
    NP_003336.1 NP_005058.3 SIAH2    BIND  PubMed hSiah2 interacts with Ubc9. 
    NP_003336.1 NP_003343.1 SUMO1    BIND  PubMed Ubc9 interacts with SUMO1. 
    NP_003336.1 NP_003343.1 SUMO1    BIND  PubMed hUbc9 interacts with SUMO-1. 
    NP_003336.1 NP_057698.2 TDP2    BIND  PubMed Ubc9 interacts with TTRAP. 
    NP_003336.1 NP_000537.2 TP53    BIND  PubMed UBE2I interacts with TP53. This interaction was modelled on a demonstrated interaction between D. melanogaster Lwr (DmUbc9) and p53 from an unspecified species. 
    NP_003336.1 NP_000537.2 TP53    BIND  PubMed p53 interacts with Ubc9. This interaction was modelled on a demonstrated interaction between p53 from human and Ubc9 from an unspecified species. 
    NP_003336.1 P17881     BIND  PubMed SEOV NP interacts with Ubc9. 
    NP_919237.1 NP_004286.2 TRAF4    BIND  PubMed TRAF4 interacts with UBC9. 
    P63279 P27695 APEX1    HPRD  PubMed  
    P63279 P10275 AR    HPRD  PubMed  
    P63279 P27540 ARNT    HPRD  PubMed  
    P63279 P15336 ATF2    HPRD  PubMed  
    P63279 P54253 ATXN1    HPRD  PubMed  
    P63279 Q13867 BLMH    HPRD  PubMed  
    P63279 Q96B23 C18orf25    HPRD  PubMed  
    P63279 O00257 CBX4    HPRD  PubMed  
    P63279 Q15744 CEBPE    HPRD  PubMed  
    P63279 Q12873 CHD3    HPRD  PubMed  
    P63279 Q9HD42 CHMP1A    HPRD  PubMed  
    P63279 Q9H444 CHMP4B    HPRD  PubMed  
    P63279 Q9UI36 DACH1    HPRD  PubMed  
    P63279 Q9UER7 DAXX    HPRD  PubMed  
    P63279 Q9Y6K1 DNMT3A    HPRD  PubMed  
    P63279 Q9UBC3 DNMT3B    HPRD  PubMed  
    P63279 P19419 ELK1    HPRD  PubMed  
    P63279 Q09472 EP300    HPRD  PubMed  
    P63279 P03372 ESR1    HPRD  PubMed  
    P63279 P14921 ETS1    HPRD  PubMed  
    P63279 P41212 ETV6    HPRD  PubMed  
    P63279 P25445 FAS    HPRD  PubMed  
    P63279 P49789 FHIT    HPRD  PubMed  
    P63279 Q06787 FMR1    HPRD  PubMed  
    P63279 Q9Y692 GMEB1    HPRD  PubMed  
    P63279 Q9UKD1 GMEB2    HPRD  PubMed  
    P63279 Q5JVS0 HABP4    HPRD  PubMed  
    P63279 Q13547 HDAC1    HPRD  PubMed  
    P63279 O14964 HGS    HPRD  PubMed  
    P63279 Q9H2X6 HIPK2    HPRD  PubMed  
    P63279 P62805 HIST2H4A    HPRD  PubMed  
    P63279 P41235 HNF4A    HPRD  PubMed  
    P63279 Q14103 HNRNPD    HPRD  PubMed  
    P63279 P61978 HNRNPK    HPRD  PubMed  
    P63279 Q03933 HSF2    HPRD  PubMed  
    P63279 Q13422 IKZF1    HPRD  PubMed  
    P63279 Q9UKT9 IKZF3    HPRD  PubMed  
    P63279 O94829 IPO13    HPRD  PubMed  
    P63279 P05412 JUN    HPRD  PubMed  
    P63279 O00180 KCNK1    HPRD  PubMed  
    P63279 P02545 LMNA    HPRD  PubMed  
    P63279 Q8NDC0 MAPK1IP1L    HPRD  PubMed  
    P63279 O75030 MITF    HPRD  PubMed  
    P63279 Q969V6 MKL1    HPRD  PubMed  
    P63279 P10242 MYB    HPRD  PubMed  
    P63279 Q8N4C6 NIN    HPRD  PubMed  
    P63279 Q14995 NR1D2    HPRD  PubMed  
    P63279 P55055 NR1H2    HPRD  PubMed  
    P63279 P04150 NR3C1    HPRD  PubMed  
    P63279 Q8IVD9 NUDCD3    HPRD  PubMed  
    P63279 Q9NR12 PDLIM7    HPRD  PubMed  
    P63279 P78364 PHC1    HPRD  PubMed  
    P63279 O75925 PIAS1    HPRD  PubMed  
    P63279 O75928 PIAS2    HPRD  PubMed  
    P63279 Protein phosphatase 2C zeta PPM1J    HPRD  PubMed  
    P63279 O75400 PRPF40A    HPRD  PubMed  
    P63279 P60484 PTEN    HPRD  PubMed  
    P63279 Q06609 RAD51    HPRD  PubMed  
    P63279 P43351 RAD52    HPRD  PubMed  
    P63279 Q9Y620 RAD54B    HPRD  PubMed  
    P63279 P49792 RANBP2    HPRD  PubMed  
    P63279 P46060 RANGAP1    HPRD  PubMed  
    P63279 O43353 RIPK2    HPRD  PubMed  
    P63279 Q92753 RORB    HPRD  PubMed  
    P63279 Q9NSC2 SALL1    HPRD  PubMed  
    P63279 Q01826 SATB1    HPRD  PubMed  
    P63279 P37088 SCNN1A    HPRD  PubMed  
    P63279 P12757 SKIL    HPRD  PubMed  
    P63279 P11166 SLC2A1    HPRD  PubMed  
    P63279 P14672 SLC2A4    HPRD  PubMed  
    P63279 Q13485 SMAD4    HPRD  PubMed  
    P63279 Q8TAD8 SNIP1    HPRD  PubMed  
    P63279 P56693 SOX10    HPRD  PubMed  
    P63279 Q06945 SOX4    HPRD  PubMed  
    P63279 P23497 SP100    HPRD  PubMed  
    P63279 Q02447 SP3    HPRD  PubMed  
    P63279 P36956 SREBF1    HPRD  PubMed  
    P63279 Q12772 SREBF2    HPRD  PubMed  
    P63279 P42224 STAT1    HPRD  PubMed  
    P63279 Stimulated by retinoic acid 13 homolog STRA13    HPRD  PubMed  
    P63279 P63165 SUMO1    HPRD  PubMed  
    P63279 P61956 SUMO2    HPRD  PubMed  
    P63279 P55854 SUMO3    HPRD  PubMed  
    P63279 P15923 TCF3    HPRD  PubMed  
    P63279 O95551 TDP2    HPRD  PubMed  
    P63279 Q92481 TFAP2B    HPRD  PubMed  
    P63279 Q92754 TFAP2C    HPRD  PubMed  
    P63279 P19438 TNFRSF1A    HPRD  PubMed  
    P63279 P11387 TOP1    HPRD  PubMed  
    P63279 Q9NS56 TOPORS    HPRD  PubMed  
    P63279 P04637 TP53    HPRD  PubMed  
    P63279 Q9BUZ4 TRAF4    HPRD  PubMed  
    P63279 Q14134 TRIM29    HPRD  PubMed  
    P63279 Q969Q1 TRIM63    HPRD  PubMed  
    P63279 Q9UBT2 UBA2    HPRD  PubMed  
    P63279 P63279 UBE2I    HPRD  PubMed  
    P63279 P09936 UCHL1    HPRD  PubMed  
    P63279 Q13432 UNC119    HPRD  PubMed  
    P63279 P19544 WT1    HPRD  PubMed  
    P63279 O96006 ZBED1    HPRD  PubMed  
    P63279 Q9Y4E5 ZNF451    HPRD  PubMed  
    P63279 O15015 ZNF646    HPRD  PubMed  
    BioGRID:113177 BioGRID:106798 ANXA1    BioGRID  PubMed Biochemical Activity 
    BioGRID:113177 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement; Two-hybrid 
    BioGRID:113177 BioGRID:107776 ATF2    BioGRID  PubMed Far Western; Two-hybrid 
    BioGRID:113177 BioGRID:120849 ATF7IP    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:106827 BIRC3    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:122670 BIRC7    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:107110 BLM    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113177 BioGRID:107111 BLMH    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:107116 BMI1    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:107140 BRCA1    BioGRID  PubMed Biochemical Activity; FRET 
    BioGRID:113177 BioGRID:127053 C18orf25    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:115315 CASP8AP2    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:117156 CBLC    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:120446 CDCA8    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:107532 CHD3    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:126170 CHMP4B    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:107569 CHUK    BioGRID  PubMed Biochemical Activity 
    BioGRID:113177 BioGRID:107775 CREB1    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:107869 CTBP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113177 BioGRID:107972 DACH1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:107985 DAXX    BioGRID  PubMed Biochemical Activity; Two-hybrid 
    BioGRID:113177 BioGRID:108025 DHX9    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:108125 DNMT3A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:108126 DNMT3B    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:127392 DTX3L    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:115021 DZIP3    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:108279 EGR2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    NP_000116.2 ESR1    BIND  PubMed ER-alpha interacts with an unspecified isoform of Ubc9. 
    BioGRID:113177 BioGRID:108403 ESR1    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:108414 ETS1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:108421 ETV6    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:111402 EXOSC9    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:106851 FAS    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113177 BioGRID:108563 FHIT    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:108619 FMR1    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:114093 GCM1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113177 BioGRID:109014 GLUL    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:109066 GOLGB1    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:246582 Grm4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113177 BioGRID:246584 Grm6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113177 BioGRID:249569 Grm7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113177 BioGRID:248875 Grm8    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113177 BioGRID:116587 HABP4    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:115106 HDAC4    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Two-hybrid 
    BioGRID:113177 BioGRID:115331 HDAC5    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:119613 HDAC7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113177 BioGRID:114593 HGS    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:109337 HIC1    BioGRID  PubMed Biochemical Activity 
    BioGRID:113177 BioGRID:128490 HIPK1    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:118815 HIPK2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:115420 HIPK3    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:113955 HIST1H4A    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:113177 BioGRID:109414 HNF4A    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:109424 HNRNPC    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:109431 HNRNPK    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:109531 HSF2    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:109547 HSPB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113177 BioGRID:109548 HSPB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113177 BioGRID:115604 IKZF1    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:116484 IKZF3    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:115025 IPO13    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113177 BioGRID:109928 JUN    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:119042 KCNIP3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113177 BioGRID:128798 LNX2    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:110378 MAP3K1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:125030 MAPK1IP1L    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:120105 MARCH5    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113177 BioGRID:116890 MGRN1    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:110432 MITF    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:113479 MKRN3    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:110687 MYB    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:114973 NCOR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:114974 NCOR2    BioGRID  PubMed Biochemical Activity 
    BioGRID:113177 BioGRID:113222 NR1H2    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:116962 NUDCD3    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:114682 PDLIM7    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:111200 PDZK1    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:121418 PELI1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:111215 PEX10    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:108233 PHC1    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:114124 PIAS1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:114523 PIAS2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:115673 PIAS3    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:119624 PIAS4    BioGRID  PubMed Biochemical Activity 
    BioGRID:113177 BioGRID:111384 PML    BioGRID  PubMed Biochemical Activity 
    BioGRID:113177 BioGRID:111461 PPARA    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:113177 BioGRID:130612 PPM1J    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113177 BioGRID:111700 PTEN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113177 BioGRID:121212 RAD18    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:111825 RAD51    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:111830 RAD52    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:117321 RAD54B    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:116750 RAD54L2    BioGRID  PubMed Two-hybrid 
    NP_006258.2 RANBP2    BIND  PubMed Ubc9 interacts with RanBP2. 
    BioGRID:113177 BioGRID:111839 RANBP2    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex; Two-hybrid 
    NP_002874.1 RANGAP1    BIND  PubMed Unspecified isoform of UBC9 conjugated with SUMO-1 sumoylates RanGAP1. This interaction was modeled on a demonstrated interaction between UBC9 from an unspecified species and RanGAP1 from an unspecified species. 
    BioGRID:113177 BioGRID:111840 RANGAP1    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity; Reconstituted Complex 
    BioGRID:113177 BioGRID:111855 RARRES3    BioGRID  PubMed Affinity Capture-Western 
    NP_000312.1 RB1    BIND  PubMed RB1 (pRb) interacts with, and is sumoylated by, an unspecified isoform of UBE2I (Ubc9). 
    BioGRID:113177 BioGRID:111865 RBBP6    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:120029 RC3H2    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:114300 RIPK2    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:115249 RNF10    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:120146 RNF111    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:122731 RNF128    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:127962 RNF133    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:129106 RNF144B    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:124834 RNF185    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:111974 RNF4    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:112023 RORB    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:114166 RUVBL1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113177 BioGRID:202582 Ranbp2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113177 BioGRID:202583 Rangap1    BioGRID  PubMed Biochemical Activity; Co-crystal Structure; Reconstituted Complex 
    BioGRID:113177 BioGRID:115366 SAE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113177 BioGRID:112206 SALL1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:112211 SATB1    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:112241 SCNN1A    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:132490 SETD8    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:115202 SETDB1    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:116699 SETX    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:112372 SIAH1    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:112373 SIAH2    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:110264 SMAD4    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:112555 SP100    BioGRID  PubMed Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:116960 SPECC1L    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:112598 SREBF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113177 BioGRID:112599 SREBF2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113177 BioGRID:128376 STRA13    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113177 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS; FRET; Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113177 BioGRID:112496 SUMO3    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:113177 BioGRID:117059 SUZ12    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113177 BioGRID:246892 Scnn1g    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113177 BioGRID:112791 TCF3    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:112855 TDG    BioGRID  PubMed Biochemical Activity 
    BioGRID:113177 BioGRID:119615 TDP2    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:112986 TNFRSF1A    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:113003 TOP1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:115505 TOPORS    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Two-hybrid 
    BioGRID:113177 BioGRID:113011 TP53BP1    BioGRID  PubMed Co-localization 
    BioGRID:113177 BioGRID:113014 TP73    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:106868 TRIM23    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:111919 TRIM27    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113177 BioGRID:117177 TRIM29    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:124780 TRIM41    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:121415 TRIM54    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:124194 TRIM55    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:124195 TRIM63    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:138920 TRIM72    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:108165 TSC22D3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113177 BioGRID:115365 UBA2    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity 
    BioGRID:113177 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113177 BioGRID:113177 UBE2I    BioGRID  PubMed Biochemical Activity; Two-hybrid 
    BioGRID:113177 BioGRID:109340 UBE2K    BioGRID  PubMed Biochemical Activity 
    BioGRID:113177 BioGRID:113192 UCHL1    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:114548 UNC119    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:113327 WT1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113177 BioGRID:106828 XIAP    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:114626 ZBED1    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:122154 ZFP106    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:113534 ZMYM2    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:117502 ZNF451    BioGRID  PubMed Two-hybrid 
    BioGRID:113177 BioGRID:115075 ZNF646    BioGRID  PubMed Two-hybrid 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the UBE2I gene: The UBE2I gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, rice, and P.falciparum.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    HLH domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to SUMO ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acid-amino acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    bHLH transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein C-terminus binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ubiquitin-protein ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of intracellular steroid hormone receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein modification process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein sumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein ubiquitination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    PML body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    synaptonemal complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    SUMO-conjugating enzyme UBC9
    Names
    SUMO-conjugating enzyme UBC9
    SUMO-protein ligase
    SUMO-1-protein ligase
    ubiquitin-protein ligase I
    ubiquitin carrier protein 9
    ubiquitin carrier protein I
    ubiquitin-protein ligase E2I
    ubiquitin conjugating enzyme 9
    ubiquitin-conjugating enzyme UbcE2A
    ubiquitin-like protein SUMO-1 conjugating enzyme
    ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
    ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9)
    NP_003336.1
    NP_919235.1
    NP_919236.1
    NP_919237.1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003345.4 → NP_003336.1  SUMO-conjugating enzyme UBC9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK291118, AL031714, BC000427, BG530957, BI793063
      Consensus CDS
      CCDS10433.1
      UniProtKB/TrEMBL
      A8K503
      UniProtKB/Swiss-Prot
      P63279
      Related
      ENSP00000380649, OTTHUMP00000045512, ENST00000397514, OTTHUMT00000109068
      Conserved Domains (1) summary
      cd00195
      Location:7 – 152
      Blast Score: 403
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. NM_194259.2 → NP_919235.1  SUMO-conjugating enzyme UBC9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional exon in the 5' UTR, as compared to variant 1.
      Source sequence(s)
      AK291118, AL031714, BF315618, BG530957, BI793063, D45050
      Consensus CDS
      CCDS10433.1
      UniProtKB/TrEMBL
      A8K503
      UniProtKB/Swiss-Prot
      P63279
      Related
      ENSP00000380650, OTTHUMP00000158629, ENST00000397515, OTTHUMT00000250319
      Conserved Domains (1) summary
      cd00195
      Location:7 – 152
      Blast Score: 403
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. NM_194260.2 → NP_919236.1  SUMO-conjugating enzyme UBC9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, as compared to variant 1.
      Source sequence(s)
      AC120498, AL031714, BI793063, CX788607
      Consensus CDS
      CCDS10433.1
      UniProtKB/Swiss-Prot
      P63279
      Related
      ENSP00000348056, OTTHUMP00000158627, ENST00000355803, OTTHUMT00000250317
      Conserved Domains (1) summary
      cd00195
      Location:7 – 152
      Blast Score: 403
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    4. NM_194261.2 → NP_919237.1  SUMO-conjugating enzyme UBC9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, as compared to variant 1.
      Source sequence(s)
      AB208988, AC120498, AL031714, BI793063
      Consensus CDS
      CCDS10433.1
      UniProtKB/Swiss-Prot
      P63279
      Related
      ENSP00000324897, OTTHUMP00000158628, ENST00000325437, OTTHUMT00000250318
      Conserved Domains (1) summary
      cd00195
      Location:7 – 152
      Blast Score: 403
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p5 Primary Assembly

      Range
      1359180..1375390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      1287987..1303737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC120498.2 (188081..195679) None
    genomic AE006466.1 AAK61274.1
    genomic AL031714.8 CAB45853.1
    genomic CH471112.2 EAW85673.1
      EAW85674.1
      EAW85675.1
      EAW85676.1
      EAW85677.1
      EAW85678.1
      EAW85679.1
    genomic HC437980.1 CBJ93564.1
    genomic HC449951.1 CBK25700.1
    mRNA AB208988.1 BAD92225.1
    mRNA AJ002385.1 CAA05359.1
    mRNA AK024172.1 None
    mRNA AK093616.1 None
    mRNA AK291118.1 BAF83807.1
    mRNA AL833737.1 None
    mRNA BC000427.2 AAH00427.1
    mRNA BC000744.2 None
    mRNA BC004429.1 AAH04429.1
    mRNA BC004437.1 None
    mRNA BC014997.1 None
    mRNA BC051289.1 AAH51289.3
    mRNA BC064492.1 None
    mRNA BC069256.1 None
    mRNA BE262845.1 None
    mRNA BF315618.1 None
    mRNA BG530957.1 None
    mRNA BI523501.1 None
    mRNA BI793063.1 None
    mRNA BQ230918.1 None
    mRNA BQ358820.1 None
    mRNA BT006932.1 AAP35578.1
    mRNA BT007010.1 AAP35656.1
    mRNA BU146357.1 None
    mRNA BU543455.1 None
    mRNA CD249028.1 None
    mRNA CX788607.1 None
    mRNA D45050.1 BAA08091.1
    mRNA U29092.1 AAC51361.1
    mRNA U31882.1 AAC50603.1
    mRNA U31933.1 AAB02181.1
    mRNA U38785.1 AAB09410.1
    mRNA U45328.1 AAA86662.1
    mRNA U66818.1 AAC50715.1
    mRNA U66867.1 AAC50716.1
    mRNA X96427.1 CAA65287.1
    other-genetic DQ891373.2 ABM82299.1
    other-genetic DQ894552.2 ABM85478.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63279.1 GenPept UniProtKB/Swiss-Prot:P63279
    Q7KZS0 GenPept UniProtKB/TrEMBL:Q7KZS0
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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