GeneRIFs: Gene References Into Functions What's a GeneRIF?

1. Studies indicate that signaling controlled by ubiquitin or ubiquitin-like proteins has recently emerged as key regulator of the cellular DNA damage response, and viruses can reveal key convergence points in this important cellular pathway.
   Title: Changing the ubiquitin landscape during viral manipulation of the DNA damage response.
2. Studies indicate that Ku80 is removed from DNA through a ubiquitin-mediated process.
   Title: Destroying the ring: Freeing DNA from Ku with ubiquitin.
3. Studies indicate that Non-proteolytic ubiquitylation of chromatin surrounding DSBs, mediated by the RNF8/RNF168 ubiquitin ligase cascade, has emerged as a key mechanism for restoration of genome integrity.
   Title: The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks.
4. Studies suggest that DNA damage-induced ubiquitination or sumoylation of PCNA prevents CRL4Cdt2-dependent degradation by inhibiting binding of Cdt1 to PCNA.
   Title: Ub-family modifications at the replication fork: Regulating PCNA-interacting components.
5. Studies indicate that monoubiquitylation of PCNA allows mutagenic translesion synthesis by damage-tolerant DNA polymerases, polyubiquitylation is required mainly for an error-free pathway that likely involves template switching.
   Title: Timing and spacing of ubiquitin-dependent DNA damage bypass.
6. Studies indicate that All the Y-family polymerases have ubiquitin binding domains that bind to mono-ubiquitinated PCNA to effect the switching from replicative to Y-family polymerase.
   Title: Ubiquitin-family modifications in the replication of DNA damage.
7. Studies indicate that Mdm2 has the ability to catalyze both mono- and poly-ubiquitination of p53.
   Title: p53 regulation by ubiquitin.
8. Studies indicate that Ubiquitin- and SUMO-mediated modification pathways have emerged as key players in regulating damage-induced template switching.
   Title: Ubiquitin family modifications and template switching.
9. Studies indicate that the involvement of the degradation-linked K48-ubiquitin signal and the proteasome at the sites of DSBs.
   Title: Degradation-linked ubiquitin signal and proteasome are integral components of DNA double strand break repair: New perspectives for anti-cancer therapy.
10. The positive rates of ubiquitin and cul-1 were significantly higher in lung cancer than those in benign lesion tissues of the lung.
    Title: Expression of ubiquitin and cullin-1 and its clinicopathological significance in benign and malignant lesions of the lung.