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Larp1 La ribonucleoprotein 1, translational regulator [ Mus musculus (house mouse) ]

Gene ID: 73158, updated on 11-Apr-2024

Summary

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Official Symbol
Larp1provided by MGI
Official Full Name
La ribonucleoprotein 1, translational regulatorprovided by MGI
Primary source
MGI:MGI:1890165
See related
Ensembl:ENSMUSG00000037331 AllianceGenome:MGI:1890165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Larp; mKIAA0731; 1810024J12Rik; 3110040D16Rik
Summary
Predicted to enable eukaryotic initiation factor 4E binding activity; nucleic acid binding activity; and ribosomal small subunit binding activity. Predicted to be involved in several processes, including TORC1 signaling; cellular response to rapamycin; and posttranscriptional regulation of gene expression. Predicted to act upstream of or within regulation of translation. Predicted to be located in cytoplasm. Predicted to be part of TORC1 complex and polysome. Predicted to be active in cytoplasmic stress granule and cytosol. Predicted to colocalize with polysomal ribosome. Is expressed in several structures, including branchial arch; cranial ganglion; epithelium; future spinal cord; and limb bud. Orthologous to human LARP1 (La ribonucleoprotein 1, translational regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 51.6), genital fat pad adult (RPKM 17.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Larp1 in Genome Data Viewer
Location:
11 B1.3; 11 35.55 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (57899711..57952860)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (57973418..58062034)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33078 Neighboring gene VISTA enhancer mm849 Neighboring gene STARR-positive B cell enhancer ABC_E6988 Neighboring gene STARR-seq mESC enhancer starr_29589 Neighboring gene STARR-positive B cell enhancer ABC_E8407 Neighboring gene STARR-positive B cell enhancer ABC_E10676 Neighboring gene reduced expression 3 (Rex3) pseudogene Neighboring gene STARR-seq mESC enhancer starr_29598 Neighboring gene predicted gene, 51897 Neighboring gene fatty acid hydroxylase domain containing 2 Neighboring gene predicted gene 12247 Neighboring gene CCR4-NOT transcription complex, subunit 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lysophosphatidic acid stimulates pericyte migration via LPA receptor 1. Yonezu Y, et al. Biochem Biophys Res Commun, 2022 Aug 27. PMID 35716596
  2. The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1). Farooq Z, et al. J Biol Chem, 2022 Sep. PMID 35863436, Free PMC Article
  3. The RNA-binding protein LARP1 is dispensable for pancreatic β-cell function and mass. Werneck-de-Castro JP, et al. Sci Rep, 2021 Jan 22. PMID 33483593, Free PMC Article
  4. dlarp, a new candidate Hox target in Drosophila whose orthologue in mouse is expressed at sites of epithelium/mesenchymal interactions. Chauvet S, et al. Dev Dyn, 2000 Jul. PMID 10878606
  5. Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function. Vincentz JW, et al. Circ Res, 2019 Aug 30. PMID 31366290, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1).
    Title: The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1).
  2. Lysophosphatidic acid stimulates pericyte migration via LPA receptor 1.
    Title: Lysophosphatidic acid stimulates pericyte migration via LPA receptor 1.
  3. The RNA-binding protein LARP1 is dispensable for pancreatic beta-cell function and mass.
    Title: The RNA-binding protein LARP1 is dispensable for pancreatic β-cell function and mass.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA 7-methylguanosine cap binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA cap binding ISO
Inferred from Sequence Orthology
more info
  
enables eukaryotic initiation factor 4E binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 5'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables ribosomal small subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables translation activator activity ISO
Inferred from Sequence Orthology
more info
  
enables translation initiation factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to rapamycin ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of TORC1 complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
la-related protein 1
Names
La ribonucleoprotein domain family, member 1
la related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028451.1 → NP_082727.1  la-related protein 1

    See identical proteins and their annotated locations for NP_082727.1

    Status: VALIDATED

    Source sequence(s)
    AL672182
    Consensus CDS
    CCDS56771.1
    UniProtKB/Swiss-Prot
    A2AFQ8, J3QNB1, Q6ZQ58, Q7TSF7
    UniProtKB/TrEMBL
    Z4YJT3
    Related
    ENSMUSP00000136673.2, ENSMUST00000178636.2
    Conserved Domains (2) summary
    smart00684
    Location:903 → 941
    DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
    cd08034
    Location:379 → 451
    LARP_1_2; La RNA-binding domain proteins similar to La-related proteins 1 and 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    57899711..57952860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157022.1 → XP_036012915.1  la-related protein 1 isoform X2

    UniProtKB/TrEMBL
    Z4YJT3
    Conserved Domains (4) summary
    smart00684
    Location:725 → 763
    DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
    PTZ00449
    Location:2 → 111
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    COG5193
    Location:171 → 355
    LHP1; La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]
    cl02755
    Location:201 → 273
    LAM; LA motif RNA-binding domain

  2. XM_006534334.4 → XP_006534397.2  la-related protein 1 isoform X1

    UniProtKB/TrEMBL
    Z4YJT3
    Conserved Domains (4) summary
    smart00684
    Location:795 → 833
    DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
    PTZ00449
    Location:62 → 181
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    COG5193
    Location:241 → 425
    LHP1; La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]
    cl02755
    Location:271 → 343
    LAM; LA motif RNA-binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZQ58.3 GenPept UniProtKB/Swiss-Prot:Q6ZQ58

Gene LinkOut

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