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1. |
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) |
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2. |
TYR haplotype carrying only the Arg402Gln variant allele was significantly associated with squamous cell carcinoma. |
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3. |
This study examined an alternative molecular approach using TYR-small interfering RNA (siRNA) to control melanogenesis in the human melanocytes. |
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4. |
activation of p38 MAPK plays an important role in LPS-induced melanogenesis by up-regulating MITF and tyrosinase expression |
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5. |
glycosylation alters the selectivity of tyrosinase processing by the proteasome, enhancing the production or survival of Tyr(369)(D) |
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6. |
Observational study and genome-wide association study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
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7. |
The R402Q tyrosinase variant does not cause autosomal recessive ocular albinism. |
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8. |
TYR is the major OCA (oculocutaneous albinism) gene in Denmark, but several patients do not have mutations in the investigated genes. |
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9. |
Four novel mutations of tyrosinase (TYR) gene have been reported in Chinese oculocutaneous albinism patients. |
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10. |
Endothelin-1 increased tyrosinase levels in melanocytes but suppressed enzyme activity. |
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11. |
Elevated serum tyrosinase is associated with malignant melanoma. |
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12. |
Results describe a series of new mutations in the OCA genes, and their role in the molecular diagnosis of oculocutaneous albinism |
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13. |
tyrosinase overexpression promotes an ataxia telangiectasia mutated-dependent p53 phosphorylation by quercetin treatment and sensitizes melanoma cells to dacarbazine. |
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14. |
plays a critical role in regulation of melanogenesis. |
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15. |
Tyrosinase-, gp100-, or TRP-2-specific CD8(+) T cells could not be identified in the peripheral blood of individuals with vitiligo. |
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16. |
alpha-synuclein reacts with tyrosinase and may have a role in Parkinson disease |
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17. |
ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma. |
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18. |
The absence of evidence for projection abnormalities in human OCA1a carriers contrasts with the previously reported evidence for abnormalities in cat-carriers of tyrosinase-related albinism. |
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19. |
Results describe the molecular detection of circulating melanoma cells by reverse transcription-polymerase chain reaction (RT-PCR) in human blood samples and in a xenograft mouse model. |
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20. |
Most patients with AROA (autosomal recessive ocular albinism) represent phenotypically mild variants of oculocutaneous albinism , well over half of which is OCA1. |
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21. |
Measurement of Melan-A, gp100, MAGE-3, MIA and tyrosinase represents a prognostic factor and a method for early detection of metastasis and treatment response of melanoma patients. |
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22. |
Observational study of genotype prevalence. (HuGE Navigator) |
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23. |
Observational study of gene-disease association. (HuGE Navigator) |
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24. |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
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25. |
Anemonin, an active compound of C. crassifolia, inhibits melanin synthesis by inhibiting the transcription of the genes encoding TYR, TRP1, and TRP2. |
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26. |
data show that chloride ion inhibited tyrosinase in a competitive manner |
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27. |
analysis of the mammalian tyrosinase active site with loss of function mutations |
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28. |
induction of retention in the early secretory pathway by abnormal acidification of melanoma cells |
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29. |
results shows that organellar pH, proteasome activity, and down-regulation of tyrosinase-related protein 1(TYRP1) expression all contribute to the lack of pigmentation in tyrosinase-positive amelanotic melanoma cells |
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30. |
Missense mutations in the tyrosinase gene is asociated with oculocutaneous albinism type 1 |
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31. |
Sequensce databases contribute to demonstrating novel mutations in tyrosinase of albinism in Indians and Japanese. |
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32. |
Data reveal DCoH/HNF-1 alpha expression and transcriptional activity in human epidermal melanocytes in vitro and in situ and identified tyrosinase, the key enzyme for pigmentation, as a new transcriptional target. |
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33. |
DNA variations - mutations and polymorphisms - in about 150 patients with Oculocutaneous albinism |
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34. |
This melanoma-associated marker was detected in melanoma cell lines. |
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35. |
fibroblasts in vitro, particularly when deliberately stressed, have the ability to increase dopa oxidase(tyrosinase) activity in melanocytes of the hair, the skin and the eye |
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36. |
The expression levels of tyrosinase mRNA and protein were also reduced by paeonol. |
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37. |
the tyrosinase autoantigen was immunorecognized with the same molecular pattern by sera from vitiligo and melanoma patients |
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38. |
no mutations in oculocutaneou albinism |
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39. |
We report a novel missense substitution, R239W(CGG --> TGG) of the tyrosinase gene in a patient with tyrosinase-negative OCA. |
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40. |
demonstrated that these cells possess tyrosinase as well as L-tyrosine hydroxylase (TH) activity and synthesize melanosomes |
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41. |
These results suggest that phosphorylation of tyrosinase by PKC-beta induces a complex formation between tyrosinase and TRP-1. |
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42. |
Antigen-specific T lymphocyte reactivity to MelanA/MART-1 and tyrosinase peptides was not observed ex vivo in our patients, and only one patient demonstrated responses to MelanA/MART-1 and tyrosinase peptides following in vitro re-stimulation. |
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43. |
OCA1 in the Tili population is due to the occurrence of a founder mutation in the TYR as indicated by haplotype analysis. Higher prevalence of the mutation in the population group is due to marriage within the same community. |
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44. |
Human Placental protein/peptide fraction mediated increase in tyrosinase expression occurred through transcriptional upregulation to stimulate melanogenesis in primary melanocyte. |
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45. |
the transmembrane anchor of a protein may crucially, albeit indirectly, control the folding pathway of the ectodomain, as shown with tyrosinase |
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46. |
IVS2-10deltt-7t-a was present in 3 out of 18 alleles in three families (16%), P310insC was present in three alleles in three families (16%) and R278X was found in three alleles (16%), and G97V (290 G-T) was found in 1 out of 18 alleles |
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47. |
Our study reports the distribution of two novel frameshift and a previously reported nonsense mutations in four OCA1 families from the Indian population. |
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48. |
We show that TYR has measurable effects on skin pigmentation differences between the west African and west European parental populations |
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49. |
A candidate gene for pigmentation. |
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50. |
tyrosinase and membrane associated transporter protein polymorphisms may have roles in oculocutaneous albinism type 1 and type 4 in the German population |
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51. |
Data suggest that maintenance of a chronically hyperpigmented phenotype in chronically photoexposed human skin is the result of a stable increase in the number of tyrosinase positive melanocytes at these sites. |
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52. |
role of P protein and tyrosinase in oculocutaneous albinism |
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53. |
Data show that oculocutaneous albinism soluble tyrosinase is an endoplasmic reticulum-associated degradation substrate that, unlike other albino tyrosinases, associates with calreticulin and BiP/GRP78, but not calnexin. |
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54. |
a tyrosinase mutation may have a role in type 1A oculocutaneous albinism (case report) |
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55. |
TYR is not a modifier of the CYP1B1-associated PCG (primary congenital glaucoma) phenotype in the Saudi Arabian population. |
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56. |
No genetic susceptibility or increased risk attributed to the tyrosinase gene family in Vogt-Koyanagi-Harada disease in Japanese. |
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57. |
tyrosinase has a role in progression of melanoma |
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58. |
tyrosinase has a role in progression of metastatic melanoma |
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59. |
glycan-specific oxidoreductase ERp57 was cross-linked to type I membrane glycoprotein tyrosinase when calnexin and calreticulin were associated |