CDK11A cyclin-dependent kinase 11A [Homo sapiens] - Gene

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Summary

Official Symbol: CDK11Aprovided by HGNC
Official Full Name: cyclin-dependent kinase 11Aprovided by HGNC
Primary source: HGNC:1730
Locus tag: RP1-283E3.2
See related: Ensembl:ENSG00000008128; MIM:116951; Vega:OTTHUMG00000000703
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CDC2L2; CDC2L3; p58GTA; PITSLRE; CDK11-p46; CDK11-p58; CDK11-p110; MGC131975
Summary: This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 1p36.33

Sequence :: Chromosome: 1; NC_000001.10 (1634169..1655791, complement)

See CDK11A in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

study identified p21 activated kinase 1 (PAK1) as a new CDK11(p58) substrate; mapped a new phosphorylation site of Ser174 on PAK1; results indicated PAK1 may serve as a downstream effector of CDK11(p58) during mitosis progression
Title: CDK11p58 phosphorylation of PAK1 Ser174 promotes DLC2 binding and roles on cell cycle progression.
These data identified a new negative regulatory protein of ERalpha and provided a new pathway by which CDK11(p58) negatively regulated cells.
Title: Repression of estrogen receptor alpha by CDK11p58 through promoting its ubiquitin-proteasome degradation.
Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis.
Title: Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis.
Observational study of gene-disease association. (HuGE Navigator)
Title: Centrosome-related genes, genetic variation, and risk of breast cancer.
CDC2L2 gene may contribute to the susceptibility of type 2 diabetes in the northern Han Chinese population.
Title: Genetic variations of the CDC2L2 gene are associated with type 2 diabetes in a Han Chinese cohort.
findings show that, in addition to playing a role in spindle formation and structure, CDK11(p58) is also required for sister chromatid cohesion and the completion of mitosis
Title: CDK11(p58) is required for the maintenance of sister chromatid cohesion.
mitotic CDK11(p58) isoform, but not the CDK11(p110) isoform, associates with mitotic centrosomes
Title: The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.
the PITSLRE IRES interacts with the Unr protein, which is more prominently expressed at the G2/M stage of the cell cycle
Title: Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2alpha.
CDK11(p58) is a new interacting protein and a novel regulator of histone acetyltransferase (HAT) HBO1.
Title: Cyclin-dependent kinase 11(p58) interacts with HBO1 and enhances its histone acetyltransferase activity.
These findings suggest that CDK11 may contribute to apoptosis by regulating the activity of NOT2 independent of its kinase activity.
Title: The cyclin-dependent kinase 11 interacts with NOT2.

Submit: New GeneRIF Correction See all (13)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q9UQ88	P15291	B4GALT1	HPRD	PubMed
Q9UQ88	P29466	CASP1	HPRD	PubMed
Q9UQ88	P42574	CASP3	HPRD	PubMed
Q9UQ88	Q14790	CASP8	HPRD	PubMed
Q9UQ88	Q9UK58	CCNL1	HPRD	PubMed
Q9UQ88	O95251	KAT7	HPRD	PubMed
Q9UQ88	Q13153	PAK1	HPRD	PubMed
Q9UQ88	Q15287	RNPS1	HPRD	PubMed
Q9UQ88	Q15477	SKIV2L	HPRD	PubMed
Q9UQ88	Q16629	SRSF7	HPRD	PubMed
BioGRID:609064	BioGRID:108950	B4GALT1	BioGRID	PubMed	Reconstituted Complex
BioGRID:609064	BioGRID:121327	CCNL1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:609064	BioGRID:123566	CCNL2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:609064	BioGRID:114214	EIF3F	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:609064	BioGRID:111095	PAK1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:609064	BioGRID:111317	PIN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:609064	BioGRID:116125	RNPS1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:609064	BioGRID:112390	SKIV2L	BioGRID	PubMed	Two-hybrid
BioGRID:609064	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:609064	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IDA Inferred from Direct Assay more info	PubMed
ATP binding	IEA Inferred from Electronic Annotation more info
cyclin-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein kinase activity	NAS Non-traceable Author Statement more info	PubMed
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
apoptotic process	IEA Inferred from Electronic Annotation more info
apoptotic process	NAS Non-traceable Author Statement more info	PubMed
blastocyst development	IEA Inferred from Electronic Annotation more info
cell division	IEA Inferred from Electronic Annotation more info
mitosis	NAS Non-traceable Author Statement more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	NAS Non-traceable Author Statement more info	PubMed
regulation of cell growth	IEP Inferred from Expression Pattern more info	PubMed
regulation of mRNA processing	IDA Inferred from Direct Assay more info	PubMed
regulation of mitosis	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: cyclin-dependent kinase 11A

Names: cyclin-dependent kinase 11A; PITSLRE B; PITSLRE protein kinase beta; cell division protein kinase 11A; cell division cycle 2-like protein kinase 2; PITSLRE serine/threonine-protein kinase CDC2L2; cell division cycle 2-like 2 (PITSLRE proteins); galactosyltransferase-associated protein kinase p58/GTA

NP_076916.2

EC 2.7.11.22

NP_277071.2

EC 2.7.11.22

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029414.1 RefSeqGene

Range

5001..26623

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_024011.2 → NP_076916.2 cyclin-dependent kinase 11A isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AF067519, AL043340, BC094827, DC388505

Consensus CDS

CCDS44042.1

UniProtKB/TrEMBL

Q4VBY6

UniProtKB/Swiss-Prot

Q9UQ88

Related

ENSP00000384442, OTTHUMP00000000760, ENST00000404249, OTTHUMT00000001731

Conserved Domains (2) summary

cd07843
Location:417 – 708
Blast Score: 1565

STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

PLN00009
Location:420 – 710
Blast Score: 761

PLN00009; cyclin-dependent kinase A; Provisional
NM_033529.2 → NP_277071.2 cyclin-dependent kinase 11A isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AF067521, AL043340, BC094827, DC388505

Consensus CDS

CCDS44043.1

UniProtKB/TrEMBL

Q4VBY6

UniProtKB/Swiss-Prot

Q9UQ88

Related

ENSP00000351629, OTTHUMP00000000763, ENST00000358779, OTTHUMT00000001734

Conserved Domains (2) summary

cd07843
Location:407 – 698
Blast Score: 1562

STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

PLN00009
Location:410 – 700
Blast Score: 759

PLN00009; cyclin-dependent kinase A; Provisional

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

1634169..1655791, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

910521..932081, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_033527.1: Suppressed sequence

Description

NM_033527.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_033532.1: Suppressed sequence

Description

NM_033532.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_033534.1: Suppressed sequence

Description

NM_033534.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF080694.1	AAC95297.1
		AAC95298.1
		AAC95299.1
		AAC95300.1
genomic	AF080695.1	AAC95299.1
genomic	AF080697.1	AAC95301.1
		AAC95302.1
		AAC95303.1
		AAC95304.1
genomic	AF092426.1	None
genomic	AL031282.1	CAI20030.1
		CAI20031.1
		CAI20032.1
		CAI20033.1
		CAI20034.1
		CAI20035.1
genomic	AL691432.53 (56048..66025)	None
genomic	CH471183.1	EAW56161.1
		EAW56162.1
		EAW56163.1
		EAW56164.1
		EAW56165.1
		EAW56166.1
		EAW56167.1
		EAW56168.1
mRNA	AF067518.1	AAC72083.1
mRNA	AF067519.1	AAC72084.1
mRNA	AF067520.1	AAC72085.1
mRNA	AF067521.1	AAC72086.1
mRNA	AF067522.1	AAC72087.1
mRNA	AF067523.1	AAC72088.1
mRNA	AF067524.1	AAC72089.1
mRNA	AF067526.1	AAC72091.1
mRNA	AF067527.1	AAC72092.1
mRNA	AF067528.1	AAC72093.1
mRNA	AF067529.1	AAC72094.1
mRNA	AL043340.1	None
mRNA	BC014464.1	AAH14464.1
mRNA	BC028187.1	AAH28187.1
mRNA	BC054019.1	None
mRNA	BC062579.1	AAH62579.1
mRNA	BC094827.1	AAH94827.1
mRNA	BC104661.1	AAI04662.1
mRNA	BC110905.1	AAI10906.1
mRNA	DC388505.1	None
mRNA	U04819.1	AAA19585.1
mRNA	U07704.1	AAA19594.1
mRNA	U07705.1	AAA19595.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q05C84	GenPept	UniProtKB/TrEMBL:Q05C84
Q3SWV2	GenPept	UniProtKB/TrEMBL:Q3SWV2
Q4VBY6	GenPept	UniProtKB/TrEMBL:Q4VBY6
Q59GL4	GenPept	UniProtKB/TrEMBL:Q59GL4
Q5QPQ9	GenPept	UniProtKB/TrEMBL:Q5QPQ9
Q5QPR3	GenPept	UniProtKB/TrEMBL:Q5QPR3
Q5QPR4	GenPept	UniProtKB/TrEMBL:Q5QPR4
Q6P5Y5	GenPept	UniProtKB/TrEMBL:Q6P5Y5
Q96CA8	GenPept	UniProtKB/TrEMBL:Q96CA8
Q9UQ88.4	GenPept	UniProtKB/Swiss-Prot:Q9UQ88