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    TUBB2A tubulin, beta 2A class IIa [ Homo sapiens ]

    Gene ID: 7280, updated on 19-May-2012

    Summary

    Official Symbol
    TUBB2Aprovided by HGNC
    Official Full Name
    tubulin, beta 2A class IIaprovided by HGNC
    Primary source
    HGNC:12412
    See related
    Ensembl:ENSG00000137267; HPRD:01852; Vega:OTTHUMG00000014135
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TUBB; TUBB2; dJ40E16.7

    Genomic context

    Location :
    6p25
    Sequence :
    Chromosome: 6; NC_000006.11 (3153900..3157783, complement)
    See TUBB2A in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene receptor (TNFRSF)-interacting serine-threonine kinase 1 Neighboring gene biphenyl hydrolase-like (serine hydrolase) Neighboring gene tubulin, beta 2B pseudogene Neighboring gene uncharacterized LOC100507194

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Rev rev Rev acts to depolymerize microtubules that are formed by tubulin, an effect that is observed during HIV-1 infection PubMed
    Tat tat In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex PubMed
    tat HIV-1 Tat (amino acids 36-39) binds tubulin alpha/beta dimers and polymerized microtubules leading to the alteration of microtubule dynamics and activation of a mitochondria-dependent apoptotic pathway that is facilitated by the Bcl-2 relative Bim PubMed
    tat HIV-1 Tat (specifically, amino acids 38-72), enhances tubulin polymerization and triggers the mitochondrial pathway to induce T cell apoptosis as shown in vitro by the release of cytochrome c from isolated mitochondria PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:113131 BioGRID:120080 ARL15    BioGRID  PubMed Two-hybrid 
    BioGRID:113131 BioGRID:120548 C20orf20    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113131 BioGRID:107539 CHGB    BioGRID  PubMed Two-hybrid 
    BioGRID:113131 BioGRID:118061 DISC1    BioGRID  PubMed Two-hybrid 
    BioGRID:113131 BioGRID:128177 EIF2C3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113131 BioGRID:115330 HDAC6    BioGRID  PubMed Biochemical Activity 
    BioGRID:113131 BioGRID:114593 HGS    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113131 BioGRID:109404 HMMR    BioGRID  PubMed Protein-peptide 
    BioGRID:113131 BioGRID:110104 LAMA4    BioGRID  PubMed Two-hybrid 
    BioGRID:113131 BioGRID:116134 MORF4L1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113131 BioGRID:115001 MORF4L2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113131 BioGRID:111087 PAFAH1B3    BioGRID  PubMed Two-hybrid 
    BioGRID:113131 BioGRID:111657 PSMA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113131 BioGRID:111689 PSMD11    BioGRID  PubMed Two-hybrid 
    BioGRID:113131 BioGRID:111766 PTPRS    BioGRID  PubMed Two-hybrid 
    BioGRID:113131 BioGRID:115818 RABAC1    BioGRID  PubMed Two-hybrid 
    BioGRID:113131 BioGRID:121946 RIC8A    BioGRID  PubMed Two-hybrid 
    BioGRID:113131 BioGRID:112038 RPA2    BioGRID  PubMed Two-hybrid 
    BioGRID:113131 BioGRID:112095 RPLP1    BioGRID  PubMed Two-hybrid 
    BioGRID:113131 BioGRID:112210 SAT1    BioGRID  PubMed Two-hybrid 
    BioGRID:113131 BioGRID:115027 SDC3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113131 BioGRID:111290 SERPINB9    BioGRID  PubMed Two-hybrid 
    BioGRID:113131 BioGRID:112681 STXBP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113131 BioGRID:112938 TK1    BioGRID  PubMed Two-hybrid 
    BioGRID:113131 BioGRID:116682 TNIK    BioGRID  PubMed Two-hybrid 
    BioGRID:113131 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113131 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • Chaperonin-mediated protein folding, organism-specific biosystem (from REACTOME)
      Chaperonin-mediated protein folding, organism-specific biosystemThe eukaryotic chaperonin TCP-1 ring complex (TRiC/ CCT) plays an essential role in the folding of a subset of proteins prominent among which are the actins and tubulins (reviewed in Altschuler and...
    • Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, organism-specific biosystem (from REACTOME)
      Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, organism-specific biosystemIn the case of actin and tubulin folding, and perhaps other substrates, the emerging polypeptide chain is transferred from the ribosome to TRiC via Prefoldin (Vainberg et al., 1998).
    • Formation of tubulin folding intermediates by CCT/TriC, organism-specific biosystem (from REACTOME)
      Formation of tubulin folding intermediates by CCT/TriC, organism-specific biosystemTriC/CCT forms a binary complex with unfolded alpha- or beta-tubulin (Frydman et al., 1992; Gao et al., 1993). The tubulin folding intermediates produced by TriC are unstable (Gao et al., 1993). Fiv...
    • Gap junction, organism-specific biosystem (from KEGG)
      Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Gap junction, conserved biosystem (from KEGG)
      Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Pathogenic Escherichia coli infection, organism-specific biosystem (from KEGG)
      Pathogenic Escherichia coli infection, organism-specific biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Pathogenic Escherichia coli infection, conserved biosystem (from KEGG)
      Pathogenic Escherichia coli infection, conserved biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Post-chaperonin tubulin folding pathway, organism-specific biosystem (from REACTOME)
      Post-chaperonin tubulin folding pathway, organism-specific biosystemAlpha and beta tubulin folding intermediates are formed through ATPâ??dependent interaction with TriC/CCT. In order to form a functional heterodimer, these folding intermediates undergo a series of...
    • Prefoldin mediated transfer of substrate to CCT/TriC, organism-specific biosystem (from REACTOME)
      Prefoldin mediated transfer of substrate to CCT/TriC, organism-specific biosystemUnfolded actins and tubulins bound to prefoldin are transferred to CCT via a docking mechanism (McCormack and Willison, 2001).
    • Protein folding, organism-specific biosystem (from REACTOME)
      Protein folding, organism-specific biosystemDue to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and...
    • Signaling events mediated by HDAC Class II, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class II, organism-specific biosystem
      Signaling events mediated by HDAC Class II
    • Signaling events mediated by HDAC Class III, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class III, organism-specific biosystem
      Signaling events mediated by HDAC Class III

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    'de novo' posttranslational protein folding TAS
    Traceable Author Statement
    more info
     
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
     
    mitosis IEA
    Inferred from Electronic Annotation
    more info
     
    neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    protein folding TAS
    Traceable Author Statement
    more info
     
    protein polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tubulin beta-2A chain
    Names
    tubulin beta-2A chain
    class IIa beta-tubulin
    tubulin, beta polypeptide 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001069.2NP_001060.1  tubulin beta-2A chain

      Status: VALIDATED

      Source sequence(s)
      AL031963, AL038778, X79535
      Consensus CDS
      CCDS4484.1
      UniProtKB/Swiss-Prot
      Q13885
      Related
      ENSP00000369703, OTTHUMP00000015956, ENST00000333628, OTTHUMT00000039662
      Conserved Domains (2) summary
      cd02187
      Location:2426
      Blast Score: 2441
      beta_tubulin; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of ...
      PLN00220
      Location:1430
      Blast Score: 2365
      PLN00220; tubulin beta chain; Provisional

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      3153900..3157783, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      3024011..3027895, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL031963.40 CAD70628.1
    genomic CH471087.1 EAW55124.1
    mRNA AK312621.1 BAG35507.1
    mRNA AL038778.2 None
    mRNA AY159127.1 AAN85571.1
    mRNA BC001194.1 AAH01194.1
    mRNA BC018780.1 AAH18780.1
    mRNA BC127873.1 None
    mRNA BC141924.1 AAI41925.1
    mRNA BC141925.1 AAI41926.1
    mRNA CR541958.1 CAG46756.1
    mRNA X79535.1 CAA56071.1
    other-genetic DQ892343.2 ABM83269.1
    other-genetic DQ895718.2 ABM86644.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13885.1 GenPept UniProtKB/Swiss-Prot:Q13885

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