Display Settings:

Format

Send to:

Choose Destination

    TTC3 tetratricopeptide repeat domain 3 [ Homo sapiens ]

    Gene ID: 7267, updated on 11-May-2012

    Summary

    Official Symbol
    TTC3provided by HGNC
    Official Full Name
    tetratricopeptide repeat domain 3provided by HGNC
    Primary source
    HGNC:12393
    See related
    Ensembl:ENSG00000182670; HPRD:03773; MIM:602259; Vega:OTTHUMG00000086654
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DCRR1; RNF105; TPRDIII; DKFZp686M0150

    Genomic context

    Location :
    21q22.2
    Sequence :
    Chromosome: 21; NC_000021.8 (38445571..38575408)
    See TTC3 in Epigenomics, MapViewer

    Chromosome 21 - NC_000021.8Genomic Context describing neighboring genes Neighboring gene Down syndrome critical region gene 6 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class P Neighboring gene Down syndrome critical region gene 9 (non-protein coding) Neighboring gene Down syndrome critical region gene 3

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P53804 Activating transcription factor 7 interacting protein ATF7IP    HPRD  PubMed  
    BioGRID:113118 BioGRID:106710 AKT1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113118 BioGRID:106711 AKT2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113118 BioGRID:115318 AKT3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113118 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113118 BioGRID:113185 UBE3A    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
     
    ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    negative regulation of cell morphogenesis involved in differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
     
    ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
     
    Component Evidence Code Pubs
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vacuole IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TTC3
    Names
    E3 ubiquitin-protein ligase TTC3
    TPR repeat protein 3
    TPR repeat protein D
    RING finger protein 105
    tetratricopeptide repeat protein 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001894.1NP_001001894.1  E3 ubiquitin-protein ligase TTC3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC063033, BI915053, BQ893819, CA420000, D83327, D84296
      Consensus CDS
      CCDS13651.1
      UniProtKB/Swiss-Prot
      P53804
      Related
      ENSP00000347889, ENST00000355666
      Conserved Domains (3) summary
      cd00162
      Location:19561996
      Blast Score: 117
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd00189
      Location:232331
      Blast Score: 187
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      pfam13414
      Location:229291
      Blast Score: 132
      TPR_11; TPR repeat
    2. NM_003316.3NP_003307.3  E3 ubiquitin-protein ligase TTC3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BQ893819, CA420000, D83077, D83327, D84296
      Consensus CDS
      CCDS13651.1
      UniProtKB/Swiss-Prot
      P53804
      Related
      ENSP00000381981, OTTHUMP00000109082, ENST00000399017, OTTHUMT00000194776
      Conserved Domains (3) summary
      cd00162
      Location:19561996
      Blast Score: 117
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd00189
      Location:232331
      Blast Score: 187
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      pfam13414
      Location:229291
      Blast Score: 132
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000021.8 Reference GRCh37.p5 Primary Assembly

      Range
      38445571..38575408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000153.1 Alternate HuRef

      Range
      23921184..24051240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

      Supplemental Content

      Recent activity

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...