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TTC3 tetratricopeptide repeat domain 3 [ Homo sapiens (human) ]

Gene ID: 7267, updated on 8-May-2016
Official Symbol
TTC3provided by HGNC
Official Full Name
tetratricopeptide repeat domain 3provided by HGNC
Primary source
HGNC:HGNC:12393
See related
Ensembl:ENSG00000182670 HPRD:03773; MIM:602259; Vega:OTTHUMG00000086654
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCRR1; RNF105; TPRDIII
Orthologs
Location:
21q22.2
Exon count:
50
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 21 NC_000021.9 (37073254..37203107)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (38445554..38575408)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372795 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class P Neighboring gene TTC3 antisense RNA 1 Neighboring gene Down syndrome critical region 9 (non-protein coding) Neighboring gene DSCR3 arrestin fold containing

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Digital quantification of human eye color highlights genetic association of three new loci.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of tetratricopeptide repeat domain 3 (TTC3) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp686M0150

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
E3 ubiquitin-protein ligase TTC3
Names
RING finger protein 105
TPR repeat protein 3
TPR repeat protein D
tetratricopeptide repeat protein 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001894.1NP_001001894.1  E3 ubiquitin-protein ligase TTC3 isoform 1

    See identical proteins and their annotated locations for NP_001001894.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences compared to variant 3. These differences cause translation initiation at a downstream AUG and result in an isoform (1) with a shorter N-terminus compared to isoform 3. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC063033, BI915053, BQ893819, CA420000, D83327, D84296
    Consensus CDS
    CCDS13651.1
    UniProtKB/Swiss-Prot
    P53804
    Related
    ENSP00000347889, ENST00000355666
    Conserved Domains (4) summary
    cd00162
    Location:19571996
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam13414
    Location:229291
    TPR_11; TPR repeat
    pfam13424
    Location:540605
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:232259
    TPR; TPR repeat [structural motif]
  2. NM_001320703.1NP_001307632.1  E3 ubiquitin-protein ligase TTC3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AI066542, AI393300, AI745113, AL040434, AP001429, AP001432, AW510696, BE780449, BG029806, BP327196, BU179028, BU508034, CD244359, CD655107, CT002499, DB484247
    Conserved Domains (5) summary
    cd00162
    Location:19972036
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam13414
    Location:251313
    TPR_11; TPR repeat
    pfam13424
    Location:562627
    TPR_12; Tetratricopeptide repeat
    pfam13431
    Location:275307
    TPR_17; Tetratricopeptide repeat
    sd00006
    Location:254281
    TPR; TPR repeat [structural motif]
  3. NM_001320704.1NP_001307633.1  E3 ubiquitin-protein ligase TTC3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' coding region and uses a downstream start codon compared to variant 3. The encoded isoform (2) has a shorter N-terminus compared to isoform 3.
    Source sequence(s)
    AA482675, AI393300, AK291992, AL040434, AP001429, AP001432, AW510696, BP327196, BU508034, CN350112, CT002499, CX868913, D84294, DB484247
    UniProtKB/Swiss-Prot
    P53804
    Conserved Domains (4) summary
    cd00162
    Location:19752014
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam13414
    Location:229291
    TPR_11; TPR repeat
    pfam13424
    Location:540605
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:232259
    TPR; TPR repeat [structural motif]
  4. NM_003316.3NP_003307.3  E3 ubiquitin-protein ligase TTC3 isoform 1

    See identical proteins and their annotated locations for NP_003307.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and has multiple coding region differences compared to variant 3. These differences cause translation initiation at a downstream AUG and result in an isoform (1) with a shorter N-terminus compared to isoform 3. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BQ893819, CA420000, D83077, D83327, D84296
    Consensus CDS
    CCDS13651.1
    UniProtKB/Swiss-Prot
    P53804
    Related
    ENSP00000381981, OTTHUMP00000109082, ENST00000399017, OTTHUMT00000194776
    Conserved Domains (4) summary
    cd00162
    Location:19571996
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam13414
    Location:229291
    TPR_11; TPR repeat
    pfam13424
    Location:540605
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:232259
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p2 Primary Assembly

    Range
    37073254..37203107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261055.1XP_005261112.1  

    See identical proteins and their annotated locations for XP_005261112.1

    Conserved Domains (3) summary
    cd00162
    Location:16651704
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam13424
    Location:230295
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:181208
    TPR; TPR repeat [structural motif]
  2. XM_005261049.1XP_005261106.1  

    See identical proteins and their annotated locations for XP_005261106.1

    Conserved Domains (4) summary
    cd00162
    Location:19912030
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam13414
    Location:245307
    TPR_11; TPR repeat
    pfam13424
    Location:556621
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:248275
    TPR; TPR repeat [structural motif]
  3. XM_005261052.1XP_005261109.1  

    See identical proteins and their annotated locations for XP_005261109.1

    Conserved Domains (4) summary
    cd00162
    Location:19752014
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam13414
    Location:229291
    TPR_11; TPR repeat
    pfam13424
    Location:540605
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:232259
    TPR; TPR repeat [structural motif]
  4. XM_005261048.1XP_005261105.1  

    See identical proteins and their annotated locations for XP_005261105.1

    Conserved Domains (4) summary
    cd00162
    Location:19912030
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam13414
    Location:245307
    TPR_11; TPR repeat
    pfam13424
    Location:556621
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:248275
    TPR; TPR repeat [structural motif]
  5. XM_005261053.1XP_005261110.1  

    Conserved Domains (4) summary
    cd00162
    Location:19752014
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam13414
    Location:229291
    TPR_11; TPR repeat
    pfam13424
    Location:540605
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:232259
    TPR; TPR repeat [structural motif]
  6. XM_005261056.1XP_005261113.1  

    See identical proteins and their annotated locations for XP_005261113.1

    Conserved Domains (3) summary
    cd00162
    Location:16651704
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam13424
    Location:230295
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:181208
    TPR; TPR repeat [structural motif]
  7. XM_005261054.2XP_005261111.1  

    See identical proteins and their annotated locations for XP_005261111.1

    Conserved Domains (4) summary
    cd00162
    Location:19752014
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam13414
    Location:229291
    TPR_11; TPR repeat
    pfam13424
    Location:540605
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:232259
    TPR; TPR repeat [structural motif]
  8. XM_005261050.3XP_005261107.1  

    See identical proteins and their annotated locations for XP_005261107.1

    Conserved Domains (4) summary
    cd00162
    Location:19912030
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam13414
    Location:245307
    TPR_11; TPR repeat
    pfam13424
    Location:556621
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:248275
    TPR; TPR repeat [structural motif]
  9. XM_011529738.1XP_011528040.1  

    Conserved Domains (4) summary
    cd00162
    Location:19732012
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam13414
    Location:245307
    TPR_11; TPR repeat
    pfam13424
    Location:556621
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:248275
    TPR; TPR repeat [structural motif]
  10. XM_011529740.1XP_011528042.1  

    See identical proteins and their annotated locations for XP_011528042.1

    UniProtKB/Swiss-Prot
    P53804
    Conserved Domains (4) summary
    cd00162
    Location:17241763
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam13424
    Location:307372
    TPR_12; Tetratricopeptide repeat
    pfam13431
    Location:2052
    TPR_17; Tetratricopeptide repeat
    sd00006
    Location:126
    TPR; TPR repeat [structural motif]
  11. XM_011529741.1XP_011528043.1  

    Conserved Domains (3) summary
    pfam13414
    Location:245307
    TPR_11; TPR repeat
    pfam13424
    Location:556621
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:248275
    TPR; TPR repeat [structural motif]
  12. XM_011529742.1XP_011528044.1  

    Related
    ENSP00000403943, OTTHUMP00000109084, ENST00000418766, OTTHUMT00000194781
    Conserved Domains (3) summary
    pfam13414
    Location:245307
    TPR_11; TPR repeat
    pfam13424
    Location:556621
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:248275
    TPR; TPR repeat [structural motif]
  13. XM_011529739.1XP_011528041.1  

    Conserved Domains (4) summary
    cd00162
    Location:17421781
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam13424
    Location:307372
    TPR_12; Tetratricopeptide repeat
    pfam13431
    Location:2052
    TPR_17; Tetratricopeptide repeat
    sd00006
    Location:126
    TPR; TPR repeat [structural motif]

Alternate CHM1_1.1

Genomic

  1. NC_018932.2 Alternate CHM1_1.1

    Range
    38007318..38137162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)