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TSPY1 testis specific protein, Y-linked 1 [ Homo sapiens (human) ]

Gene ID: 7258, updated on 4-May-2015
Official Symbol
TSPY1provided by HGNC
Official Full Name
testis specific protein, Y-linked 1provided by HGNC
Primary source
HGNC:HGNC:12381
See related
Ensembl:ENSG00000258992; HPRD:11852; MIM:480100; Vega:OTTHUMG00000171452
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT78; TSPY; DYS14; pJA923
Summary
The protein encoded by this gene is found only in testicular tissue and may be involved in spermatogenesis. Approximately 35 copies of this gene are present in humans, but only a single, nonfunctional orthologous gene is found in mouse. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
See TSPY1 in MapViewer
Location:
Yp11.2
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) Y NC_000024.10 (9466955..9469749)
105 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (9304564..9307359)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene testis specific protein, Y-linked 3 Neighboring gene family with sequence similarity 197, Y-linked, member 5, pseudogene Neighboring gene family with sequence similarity 197, Y-linked, member 4, pseudogene Neighboring gene testis specific protein, Y-linked 9, pseudogene

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
gonadal mesoderm development IEA
Inferred from Electronic Annotation
more info
 
nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
sex differentiation TAS
Traceable Author Statement
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
testis-specific Y-encoded protein 1
Names
testis-specific Y-encoded protein 1
cancer/testis antigen 78

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027958.1 RefSeqGene

    Range
    5001..7795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001197242.1NP_001184171.1  testis-specific Y-encoded protein 1 isoform TSPY-S

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of a coding exon compared to variant 1, that causes a frameshift. The resulting isoform (TSPY-S) has a shorter and distinct C-terminus compared to isoform TSPY1-L.
    Source sequence(s)
    AC006156, AI002165, AY130858
    Consensus CDS
    CCDS76071.1
    UniProtKB/TrEMBL
    Q540R4
    Related
    ENSP00000389324, ENST00000423647
    Conserved Domains (1) summary
    pfam00956
    Location:110265
    NAP; Nucleosome assembly protein (NAP)
  2. NM_003308.3NP_003299.2  testis-specific Y-encoded protein 1 isoform TSPY-L

    See identical proteins and their annotated locations for NP_003299.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (TSPY-L).
    Source sequence(s)
    AC006156, AI002165, BC121113
    Consensus CDS
    CCDS48205.1
    UniProtKB/TrEMBL
    A4FUW6
    UniProtKB/Swiss-Prot
    Q01534
    Related
    ENSP00000403304, OTTHUMP00000246057, ENST00000451548, OTTHUMT00000413463
    Conserved Domains (1) summary
    pfam00956
    Location:110288
    NAP; Nucleosome assembly protein (NAP)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p2 Primary Assembly

    Range
    9466955..9469749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)