Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Rps6kb1provided by MGI
Official Full Name: ribosomal protein S6 kinase, polypeptide 1provided by MGI
Primary source: MGI:1270849
Locus tag: RP23-467J12.2
See related: Ensembl:ENSMUSG00000020516; Vega:OTTMUSG00000001198
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: S6K1; 70kDa; p70s6k; AA959758; AI256796; AI314060; p70/85s6k; 2610318I15Rik; 4732464A07Rik

Genomic context

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Location :: 11 C; 11

Sequence :: Chromosome: 11; NC_000077.6 (86499009..86544807, complement)

See Rps6kb1 in Epigenomics, MapViewer

Chromosome 11 - NC_000077.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Downregulation of either tlr2 or tlr4 gene expression by small interfering RNAs prevented the activation of both p38 MAPK and S6K1 by FSL-1, lipopolysaccharide or palmitic acid.
Title: TLR2 and TLR4 activation induces p38 MAPK-dependent phosphorylation of S6 kinase 1 in C2C12 myotubes.
A novel mechanism has been uncovered for mutual positive regulation between S6K1 and Arg-II in endothelial inflammation and aging.
Title: Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging.
HB-EGF induced heart fibrosis and proliferation of cardiac fibroblasts occurs through activation of the Akt/mTor/p70s6k pathway
Title: Heparin-binding EGF-like growth factor induces heart interstitial fibrosis via an Akt/mTor/p70s6k pathway.
in the absence of 4E-BP proteins, mTORC1-mediated phosphorylation of p70S6K1 is elevated by a reduction in competition between the two substrates for interaction with raptor
Title: Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor.
SHP-2 positively regulates p70 S6 kinase 1 phosphorylation in myoblasts in response to leucine stimulation.
Title: Novel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling.
Maintenance of eIF4E interaction with eIF4G was not by itself sufficient to sustain global rates of protein synthesis in the absence of mTORC1 signaling to p70S6K1; phosphorylation of both eIF4B and PDCD4 was additionally required.
Title: Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis.
This study found that genetic reduction of S6K1 prevented elevated phosphorylation of translational control molecules, exaggerated protein synthesis, enhanced mGluR-dependent long-term depression (LTD), weight gain, and macro-orchidism in FXS model mice.
Title: Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic, and behavioral phenotypes in fragile X syndrome mice.
identified a novel role for hypothalamic p70 S6 kinase 1 (S6K1), a major downstream effector of the kinase mammalian target of rapamycin, in leucine deprivation stimulation of energy expenditure.
Title: S6K1 in the central nervous system regulates energy expenditure via MC4R/CRH pathways in response to deprivation of an essential amino acid.
When S6K1 inactivation is combined with the deletion of the mTORC2 substrate Akt2, glucose homeostasis is compromised due to defects in both insulin action and beta-cell function.
Title: The combined deletion of S6K1 and Akt2 deteriorates glycemic control in a high-fat diet.
p70S6 kinase forms a complex with alpha2AMPK, resulting in phosphorylation on serine(491).
Title: p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake.

Submit: New GeneRIF Correction See all (70)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (2) 1 citation
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_082535.1	NP_033122.1	Rps6	BIND	PubMed	Rps6kb1 (S6K1) interacts with rpS6. This interaction was modelled on a demonstrated interaction between mouse Rps6kb1 and rpS6 from an unspecified species.
BioGRID:215408	BioGRID:200788	Irs1	BioGRID	PubMed	Biochemical Activity
BioGRID:215408	BioGRID:111580	MAPK1	BioGRID	PubMed	Reconstituted Complex
BioGRID:215408	BioGRID:107819	MAPK14	BioGRID	PubMed	Reconstituted Complex
BioGRID:215408	BioGRID:111581	MAPK3	BioGRID	PubMed	Reconstituted Complex
BioGRID:215408	BioGRID:111585	MAPK8	BioGRID	PubMed	Reconstituted Complex
BioGRID:215408	BioGRID:111587	MAPK9	BioGRID	PubMed	Reconstituted Complex
BioGRID:215408	BioGRID:108757	MTOR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:215408	BioGRID:208141	Mlst8	BioGRID	PubMed	Biochemical Activity
BioGRID:215408	BioGRID:208142	Mtor	BioGRID	PubMed	Biochemical Activity
BioGRID:215408	BioGRID:216698	Rptor	BioGRID	PubMed	Biochemical Activity

Pathways from BioSystems

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Acute myeloid leukemia, organism-specific biosystem (from KEGG)
Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
Acute myeloid leukemia, conserved biosystem (from KEGG)
Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ???? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation...
ErbB signaling pathway, organism-specific biosystem (from KEGG)
ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
ErbB signaling pathway, conserved biosystem (from KEGG)
ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
G13 Signaling Pathway, organism-specific biosystem (from WikiPathways)
G13 Signaling Pathway, organism-specific biosystemThe G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cell...
HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
IGF1R signaling cascade, organism-specific biosystem (from REACTOME)
IGF1R signaling cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-2 Signaling Pathway, organism-specific biosystemInterleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 ...
IL-4 signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-4 signaling Pathway, organism-specific biosystem
IL-4 signaling Pathway
IL-6 signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-6 signaling Pathway, organism-specific biosystem
IL-6 signaling Pathway
IRS-mediated signalling, organism-specific biosystem (from REACTOME)
IRS-mediated signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
IRS-related events, organism-specific biosystem (from REACTOME)
IRS-related events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
IRS-related events triggered by IGF1R, organism-specific biosystem (from REACTOME)
IRS-related events triggered by IGF1R, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Insulin Signaling, organism-specific biosystem (from WikiPathways)
Insulin Signaling, organism-specific biosystem
Insulin Signaling
Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
Insulin receptor signalling cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Insulin signaling pathway, organism-specific biosystem (from KEGG)
Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
Insulin signaling pathway, conserved biosystem (from KEGG)
Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
PI3K Cascade, organism-specific biosystem (from REACTOME)
PI3K Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K/Akt/mTOR signaling pathway, organism-specific biosystem (from LIPID MAPS)
PI3K/Akt/mTOR signaling pathway, organism-specific biosystem
PI3K/Akt/mTOR signaling pathway
PKB-mediated events, organism-specific biosystem (from REACTOME)
PKB-mediated events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
S6K1 signalling, organism-specific biosystem (from REACTOME)
S6K1 signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
S6K1-mediated signalling, organism-specific biosystem (from REACTOME)
S6K1-mediated signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
Signaling by Insulin receptor, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemcomputationally inferred pathway (not manually curated)
TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
TGF-beta signaling pathway, conserved biosystem (from KEGG)
TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem
TNF-alpha NF-kB Signaling Pathway
mTOR signaling pathway, organism-specific biosystem (from KEGG)
mTOR signaling pathway, organism-specific biosystem
mTOR signaling pathway
mTOR signaling pathway, conserved biosystem (from KEGG)
mTOR signaling pathway, conserved biosystem
mTOR signaling pathway
mTOR signalling, organism-specific biosystem (from REACTOME)
mTOR signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
mTORC1-mediated signalling, organism-specific biosystem (from REACTOME)
mTORC1-mediated signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

AV007605 (e-PCR)
- UniSTS:164473

AA959758 (e-PCR)
- UniSTS:160138

NoName (e-PCR)
- UniSTS:236687

AI314060 (e-PCR)
- UniSTS:165783

Rps6kb1 (e-PCR), detects polymorphism
- UniSTS:528298

RH136097 (e-PCR)
- UniSTS:210092

Homology

Homologs of the Rps6kb1 gene: The Rps6kb1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, and rice.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ATP binding	ISO Inferred from Sequence Orthology more info
kinase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
peptide binding	ISO Inferred from Sequence Orthology more info
protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
protein kinase activity	ISO Inferred from Sequence Orthology more info
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
ribosomal protein S6 kinase activity	ISO Inferred from Sequence Orthology more info
transferase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
TOR signaling cascade	ISO Inferred from Sequence Orthology more info
apoptotic process	IEA Inferred from Electronic Annotation more info
cell cycle	IEA Inferred from Electronic Annotation more info
cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
germ cell development	IDA Inferred from Direct Assay more info	PubMed
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
positive regulation of skeletal muscle tissue growth	ISO Inferred from Sequence Orthology more info
positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of translation	ISO Inferred from Sequence Orthology more info
positive regulation of translational initiation	ISO Inferred from Sequence Orthology more info
protein kinase B signaling cascade	IGI Inferred from Genetic Interaction more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	IEA Inferred from Electronic Annotation more info
protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
protein phosphorylation	ISO Inferred from Sequence Orthology more info
regulation of glucose import	ISO Inferred from Sequence Orthology more info
regulation of translation	IEA Inferred from Electronic Annotation more info
response to insulin stimulus	ISO Inferred from Sequence Orthology more info
response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cell junction	IEA Inferred from Electronic Annotation more info
cell surface	ISO Inferred from Sequence Orthology more info
cytoplasm	ISO Inferred from Sequence Orthology more info
membrane	IEA Inferred from Electronic Annotation more info
mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
mitochondrion	IDA Inferred from Direct Assay more info	PubMed
mitochondrion	ISO Inferred from Sequence Orthology more info
neuron projection	IEA Inferred from Electronic Annotation more info
nucleus	ISO Inferred from Sequence Orthology more info
perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
ribosome	IEA Inferred from Electronic Annotation more info
synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribosomal protein S6 kinase beta-1

Names: ribosomal protein S6 kinase beta-1; S6K; P70S6K1; p70 S6KA; p70-S6K 1; S6K-beta-1; p70 S6K-alpha; p70 S6 kinase alpha; p70 ribosomal S6 kinase alpha; ribosomal protein S6 kinase I; 70 kDa ribosomal protein S6 kinase 1; ribosomal protein S6 kinase, 70kD, polypeptide 1

NP_001107806.1

EC 2.7.11.1

NP_082535.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114334.1 → NP_001107806.1 ribosomal protein S6 kinase beta-1 isoform 1

Status: VALIDATED

Source sequence(s)

AK032724, AK135716, AL604063

Consensus CDS

CCDS48875.1

UniProtKB/TrEMBL

Q3UXD8

UniProtKB/Swiss-Prot

Q8BSK8

Related

ENSMUSP00000119715, OTTMUSP00000001172, ENSMUST00000154617, OTTMUST00000002379

Conserved Domains (2) summary

cd05584
Location:94 – 416
Blast Score: 1806

STKc_p70S6K; Catalytic domain of the Protein Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

smart00220
Location:91 – 352
Blast Score: 831

S_TKc; Serine/Threonine protein kinases, catalytic domain
NM_028259.4 → NP_082535.1 ribosomal protein S6 kinase beta-1 isoform 2

Status: VALIDATED

Source sequence(s)

AL604063

Consensus CDS

CCDS25201.1

UniProtKB/TrEMBL

Q8C3J7

Related

ENSMUSP00000053188, OTTMUSP00000001173, ENSMUST00000058286, OTTMUST00000002380

Conserved Domains (1) summary

cl09925
Location:94 – 195
Blast Score: 580

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000077.6 Reference GRCm38.p1 C57BL/6J

Range

86499009..86544807, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000033.1 Alternate Mm_Celera

Range

96115093..96160675, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01094935.1 (10904..37976)	None
genomic	AAHY01094936.1	None
genomic	AAHY01094937.1	None
genomic	AJ000654.1	CAA04202.1	129/Sv
genomic	AL604063.4 (18568..64367)	None
genomic	CH466556.1	EDL15788.1	mixed
mRNA	AK012045.1	BAB27991.1	C57BL/6J
mRNA	AK028860.1	None	C57BL/6J
mRNA	AK032724.1	BAC28000.1	C57BL/6J
mRNA	AK035354.1	None	C57BL/6J
mRNA	AK037987.1	None	C57BL/6J
mRNA	AK038186.1	None	C57BL/6J
mRNA	AK053930.1	None	C57BL/6J
mRNA	AK079278.1	None	C57BL/6J
mRNA	AK085687.1	BAC39506.1	C57BL/6J
mRNA	AK135716.1	BAE22625.1	C57BL/6J
mRNA	AK143689.1	None	C57BL/6J
mRNA	AK163258.1	None	C57BL/6J
mRNA	AK165329.1	None	C57BL/6J
mRNA	AK178169.1	None
mRNA	AK185155.1	None
mRNA	AK214758.1	None
mRNA	BC038491.1	AAH38491.1	CZECHII
mRNA	BC071244.1	AAH71244.1	C57BL/6J