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    Palld palladin, cytoskeletal associated protein [ Mus musculus (house mouse) ]

    Gene ID: 72333, updated on 5-May-2013
    Official Symbol
    Palldprovided by MGI
    Official Full Name
    palladin, cytoskeletal associated proteinprovided by MGI
    Primary source
    MGI:1919583
    See related
    Ensembl:ENSMUSG00000058056
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6030492A02; 2410003B16Rik
    Location :
    8; 8 B3.3
    Sequence :
    Chromosome: 8; NC_000074.6 (61515021..61902690, complement)
    See Palld in Epigenomics, MapViewer

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene SH3 domain containing ring finger 1 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene carbonyl reductase 4 Neighboring gene predicted gene 3014 Neighboring gene RIKEN cDNA 4930512H18 gene Neighboring gene lysyl-tRNA synthetase pseudogene Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 Neighboring gene annexin A10

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells. Ogaki S, et al. BMC Dev Biol, 2011 Mar 1. PMID 21362171.
    2. The actin associated protein palladin is important for the early smooth muscle cell differentiation. Jin L, et al. PLoS One, 2010 Sep 22. PMID 20877641.
    3. Isoform-specific upregulation of palladin in human and murine pancreas tumors. Goicoechea SM, et al. PLoS One, 2010 Apr 26. PMID 20436683.
    4. Target deletion of the cytoskeleton-associated protein palladin does not impair neurite outgrowth in mice. Shu RZ, et al. PLoS One, 2009 Sep 4. PMID 19730728.
    5. Characterization of interaction between CLP36 and palladin. Maeda M, et al. FEBS J, 2009 May. PMID 19366376.

    See all (31) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. upregulation of 85-90 kDa palladin isoform may play a role in the establishment of the tumor-associated fibroblasts phenotype, and thus in the formation of a desmoplastic tumor microenvironment
      Title: Isoform-specific upregulation of palladin in human and murine pancreas tumors.
    2. Actin associated protein palladin is important for the early smooth muscle cell differentiation.
      Title: The actin associated protein palladin is important for the early smooth muscle cell differentiation.
    3. palladin is dispensable for normal neurite outgrowth in mice
      Title: Target deletion of the cytoskeleton-associated protein palladin does not impair neurite outgrowth in mice.
    4. results indicate that alpha-actinin, CLP36 and palladin form a protein complex and contribute to regulation of the actin cytoskeleton
      Title: Characterization of interaction between CLP36 and palladin.
    5. Palladin is essential for expression of the full complement of contractile proteins necessary for optimal force development of smooth muscle cells derived from embryoid bodies
      Title: The actin-associated protein Palladin is required for development of normal contractile properties of smooth muscle cells derived from embryoid bodies.
    6. expression analysis of the murine palladin isoforms
      Title: Comparative expression analysis of the murine palladin isoforms.
    7. palladin is crucial for definitive erythropoiesis and erythroblastic island formation
      Title: Disruption of palladin leads to defects in definitive erythropoiesis by interfering with erythroblastic island formation in mouse fetal liver.
    8. Here, we demonstrate that palladin is a binding partner for profilin, interacting with profilin via a poly proline-containing sequence in the amino-terminal half of palladin.
      Title: The proline-rich protein palladin is a binding partner for profilin.
    9. We propose that palladin is required for the initiation of neural tube closure and provides an important new candidate that may be implicated in the etiology of human NTDs.
      Title: Disruption of palladin results in neural tube closure defects in mice.
    10. The actin-associated protein palladin may play an important role in recruiting VASP to sites of actin filament growth, anchorage, and crosslinking.
      Title: Palladin is a novel binding partner for Ena/VASP family members.
    Submit: New GeneRIF Correction
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:215316 BioGRID:202919 Rnf2    BioGRID  PubMed Affinity Capture-MS 

    Markers

    Genotypes

    Homology

    Clone Names

    • MGC150248

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    actin filament ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Preferred Names
    palladin
    Names
    palladin
    palladin isoform
    90kDa actin-associated protein palladin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081390.1 → NP_001074859.1  palladin

      Status: PROVISIONAL

      Source sequence(s)
      AC121881, AC139846, AC147616
      Consensus CDS
      CCDS40350.1
      UniProtKB/Swiss-Prot
      Q9ET54
      Related
      ENSMUSP00000034057, ENSMUST00000034057
      Conserved Domains (3) summary
      cd00096
      Location:465 – 542
      Blast Score: 159
      Ig; Immunoglobulin domain
      cd05893
      Location:1034 – 1108
      Blast Score: 415
      Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
      pfam07679
      Location:278 – 368
      Blast Score: 283
      I-set; Immunoglobulin I-set domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p1 C57BL/6J

      Range
      61515021..61902690, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000030.1 Alternate Mm_Celera

      Range
      64078203..64475199, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01071355.1 None
    genomic AAHY01071356.1 None
    genomic AAHY01071357.1 None
    genomic AAHY01071358.1 None
    genomic AAHY01071359.1 None
    genomic AAHY01071360.1 None
    genomic AAHY01071361.1 None
    genomic AAHY01071362.1 None
    genomic AAHY01071363.1 None
    genomic AAHY01071364.1 None
    genomic AAHY01071365.1 None
    genomic AAHY01071366.1 None
    genomic AAHY01071367.1 None
    genomic AAHY01071368.1 None
    genomic AAHY01071369.1 None
    genomic AAHY01071370.1 None
    genomic AAHY01071371.1 None
    genomic AAHY01071372.1 None
    genomic AAHY01071373.1 None
    genomic AAHY01071374.1 None
    genomic AAHY01071375.1 None
    genomic AAHY01071376.1 (28491..45247) None
    genomic AC121881.3 (40445..184359) None
    genomic AC139846.4 (53923..149846) None
    genomic AC147616.3 (30556..182152) None
    mRNA AF205078.1 AAG00078.1 Swiss Webster/NIH
    mRNA AF205079.1 AAG00079.1 ICR
    mRNA AK010350.1 BAB26871.1 C57BL/6J
    mRNA AK031696.1 None C57BL/6J
    mRNA AK052157.1 None C57BL/6J
    mRNA AK052489.1 None C57BL/6J
    mRNA AK076423.1 None C57BL/6J
    mRNA AK077756.1 None C57BL/6J
    mRNA AK079524.1 None C57BL/6J
    mRNA AK087270.1 None C57BL/6J
    mRNA AK087573.1 BAC39934.1 C57BL/6J
    mRNA AK149663.1 None C57BL/6J
    mRNA AK162050.1 None C57BL/6J
    mRNA AK173081.1 BAD32359.1
    mRNA BC027364.1 None FVB/N
    mRNA BC076588.1 AAH76588.1 C57BL/6
    mRNA BC127081.1 AAI27082.1
    mRNA JX477684.1 AFS88929.1 C57BL/6
    other-genetic BC167194.1 AAI67194.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ET54.2 GenPept UniProtKB/Swiss-Prot:Q9ET54

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
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      • 3D structures
        3D structure of a gene
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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