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    TRPC3 transient receptor potential cation channel, subfamily C, member 3 [ Homo sapiens ]

    Gene ID: 7222, updated on 19-May-2012
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    Summary

    Official Symbol
    TRPC3provided by HGNC
    Official Full Name
    transient receptor potential cation channel, subfamily C, member 3provided by HGNC
    Primary source
    HGNC:12335
    See related
    Ensembl:ENSG00000138741; HPRD:15999; MIM:602345; Vega:OTTHUMG00000133069
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRP3
    Summary
    The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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    Genomic context

    Location :
    4q27
    Sequence :
    Chromosome: 4; NC_000004.11 (122800183..122872909, complement)
    See TRPC3 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene exosome component 9 Neighboring gene cyclin A2 Neighboring gene Bardet-Biedl syndrome 7 Neighboring gene KIAA1109 Neighboring gene adenosine deaminase domain containing 1 (testis-specific)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Lack of kinase regulation of canonical transient receptor potential 3 (TRPC3) channel-dependent currents in cerebellar Purkinje cells. Nelson C, et al. J Biol Chem, 2012 Feb 24. PMID 22207762.
    2. Decreased expression of transient receptor potential channels in cerebral vascular tissue from patients after hypertensive intracerebral hemorrhage. Thilo F, et al. Clin Exp Hypertens, 2011. PMID 21957871.
    3. Genotype of an individual single nucleotide polymorphism regulates DNA methylation at the TRPC3 alternative promoter. Martin-Trujillo A, et al. Epigenetics, 2011 Oct 1. PMID 21931279.
    4. Calcium-dependent expression of transient receptor potential canonical type 3 channels in patients with chronic kidney disease. Liu Y, et al. Arch Biochem Biophys, 2011 Oct. PMID 21802402.
    5. The transient receptor potential (TRP) channel TRPC3 TRP domain and AMP-activated protein kinase binding site are required for TRPC3 activation by erythropoietin. Hirschler-Laszkiewicz I, et al. J Biol Chem, 2011 Sep 2. PMID 21757714.

    See all (93) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The TRPC3 alternative promoter is a methylation quantitative-trait locus associated with the ataxia phenotype.
      Title: Genotype of an individual single nucleotide polymorphism regulates DNA methylation at the TRPC3 alternative promoter.
    2. We find that in Purkinje cells, activation of TRPC3-dependent currents is not inhibited by conventional PKC or PKG to any significant extent and that inhibition of these kinases does not significantly impact on TRPC3-mediated currents either.
      Title: Lack of kinase regulation of canonical transient receptor potential 3 (TRPC3) channel-dependent currents in cerebellar Purkinje cells.
    3. TRPC3 expression is associated with hypertension and hypoxic conditions in human cerebral vascular tissue.
      Title: Decreased expression of transient receptor potential channels in cerebral vascular tissue from patients after hypertensive intracerebral hemorrhage.
    4. Higher levels of TRPC3 expression is associated with treatment response in lung adenocarcinoma.
      Title: Expression of the transient receptor potential channel c3 correlates with a favorable prognosis in patients with adenocarcinoma of the lung.
    5. Our findings suggest that mutations in TRPC3 do not significantly contribute to the cause of late-onset and episodic human cerebellar ataxias
      Title: Candidate screening of the TRPC3 gene in cerebellar ataxia.
    6. There is a significant increase of TRPC3 channel protein expression in patients with chronic kidney disease compared to healthy control subjects (normalized expression, 0.42+/-0.06 vs. 0.19+/-0.03; p<0.01).
      Title: Calcium-dependent expression of transient receptor potential canonical type 3 channels in patients with chronic kidney disease.
    7. analysis of the role of specific domains in the different responsiveness of TRPC3 and TRPC6 to erythropoietin
      Title: The transient receptor potential (TRP) channel TRPC3 TRP domain and AMP-activated protein kinase binding site are required for TRPC3 activation by erythropoietin.
    8. A central role is demonstrated for sodium entry via TRPC3/6 channels via receptor-mediated increases in intracellular calcium.
      Title: Selective interference with TRPC3/6 channels disrupts OX1 receptor signalling via NCX and reveals a distinct calcium influx pathway.
    9. TRPC3 modulates Ca(2)+-dependent proliferation of primary CD4+ T-cells indicating that TRPC3 may be involved in Ca(2)+ homeostasis in T cells.
      Title: TRP expression pattern and the functional importance of TRPC3 in primary human T-cells.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
    Submit: New GeneRIF Correction See all (67)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_003296.1 NP_002453.1 MX1    BIND  PubMed MxA interacts with TRPC3. This interaction was modeled on a demonstrated interaction between human MxA and TRPC3 from unspecified species. 
    NP_003296.1 NP_003818.2 NAPA    BIND  PubMed TRPC3 interacts with alpha-SNAP. 
    NP_003296.1 NP_055047.1 VAMP2    BIND  PubMed TRPC3 interacts with VAMP2. 
    Q13507 Calmodulin 1 CALM1    HPRD  PubMed  
    Q13507 P62942 FKBP1A    HPRD  PubMed  
    Q13507 P29992 GNA11    HPRD  PubMed  
    Q13507 Q14643 ITPR1    HPRD  PubMed  
    Q13507 Q14573 ITPR3    HPRD  PubMed  
    Q13507 P20591 MX1    HPRD  PubMed  
    Q13507 P54920 NAPA    HPRD  PubMed  
    Q13507 Q96D31 ORAI1    HPRD  PubMed  
    Q13507 Q9NQ66 PLCB1    HPRD  PubMed  
    Q13507 Q00722 PLCB2    HPRD  PubMed  
    Q13507 Q01970 PLCB3    HPRD  PubMed  
    Q13507 P19174 PLCG1    HPRD  PubMed  
    Q13507 PLCG1    BIND  PubMed PLCG1 interacts with TRPC3. This interaction was modelled on a demonstrated interaction between rat PLCG1 and human TRPC3. 
    Q13507 P17252 PRKCA    HPRD  PubMed  
    Q13507 P14619 PRKG1    HPRD  PubMed  
    Q13507 P32418 SLC8A1    HPRD  PubMed  
    Q13507 Q13277 STX3    HPRD  PubMed  
    Q13507 P48995 TRPC1    HPRD  PubMed  
    Q13507 Q9Y210 TRPC6    HPRD  PubMed  
    Q13507 P63027 VAMP2    HPRD  PubMed  
    BioGRID:113073 BioGRID:109913 ITPR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113073 BioGRID:109915 ITPR3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113073 BioGRID:113071 TRPC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113073 BioGRID:113073 TRPC3    BioGRID  PubMed Affinity Capture-Western; FRET 
    BioGRID:113073 BioGRID:113074 TRPC4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113073 BioGRID:113075 TRPC5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113073 BioGRID:113076 TRPC6    BioGRID  PubMed Affinity Capture-Western; FRET 
    BioGRID:113073 BioGRID:121378 TRPC7    BioGRID  PubMed FRET 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Effects of PIP2 hydrolysis, organism-specific biosystem (from REACTOME)
      Effects of PIP2 hydrolysis, organism-specific biosystemHydrolysis of phosphatidyl inositol-bisphosphate (PIP2) by phospholipase C (PLC) produces diacylglycerol (DAG) and inositol triphosphate (IP3). Both are potent second messengers. IP3 diffuses into th...
    • Elevation of cytosolic Ca2+ levels, organism-specific biosystem (from REACTOME)
      Elevation of cytosolic Ca2+ levels, organism-specific biosystemActivation of non- excitable cells involves the agonist-induced elevation of cytosolic Ca2+, an essential process for platelet activation. It occurs through Ca2+ release from intracellular stores and...
    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Netrin-1 signaling, organism-specific biosystem (from REACTOME)
      Netrin-1 signaling, organism-specific biosystemNetrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse a...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Platelet calcium homeostasis, organism-specific biosystem (from REACTOME)
      Platelet calcium homeostasis, organism-specific biosystemCa2+ homeostasis is controlled by processes that elevate or counter the elevation of cytosolic Ca2+. During steady state conditions, cytoplasmic Ca2+ is reduced by the accumulation of Ca2+ in intrac...
    • Platelet homeostasis, organism-specific biosystem (from REACTOME)
      Platelet homeostasis, organism-specific biosystemUnder normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in charact...
    • Role of second messengers in netrin-1 signaling, organism-specific biosystem (from REACTOME)
      Role of second messengers in netrin-1 signaling, organism-specific biosystemThe levels of second messengers such as Ca+2, cAMP and cGMP may regulate the response of the growth cone to a particular cue. Netrin-1 as a guidance molecule depends on intracellular Ca+2 concentrati...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Trk receptor signaling mediated by PI3K and PLC-gamma, organism-specific biosystem (from Pathway Interaction Database)
      Trk receptor signaling mediated by PI3K and PLC-gamma, organism-specific biosystem
      Trk receptor signaling mediated by PI3K and PLC-gamma

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium activated cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    calcium channel activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cation channel activity TAS
    Traceable Author Statement
    more info
    		  
    inositol 1,4,5 trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    store-operated calcium channel activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    axon guidance TAS
    Traceable Author Statement
    more info
    		  
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    calcium ion transmembrane transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    calcium ion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    phototransduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    platelet activation TAS
    Traceable Author Statement
    more info
    		  
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    integral to plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    short transient receptor potential channel 3
    Names
    short transient receptor potential channel 3
    hTrp-3
    transient receptor protein 3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030368.1 RefSeqGene

      Range
      5001..77727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130698.1 → NP_001124170.1  short transient receptor potential channel 3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AY865574, Y13758
      Consensus CDS
      CCDS47130.1
      UniProtKB/Swiss-Prot
      Q13507
      Related
      ENSP00000368966, OTTHUMP00000219929, ENST00000379645, OTTHUMT00000364252
      Conserved Domains (4) summary
      cd00204
      Location:119 – 253
      Blast Score: 159
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08344
      Location:267 – 329
      Blast Score: 297
      TRP_2; Transient receptor ion channel II
      TIGR00870
      Location:96 – 890
      Blast Score: 2262
      trp; transient-receptor-potential calcium channel protein
      pfam08016
      Location:468 – 750
      Blast Score: 153
      PKD_channel; Polycystin cation channel

    2. NM_003305.2 → NP_003296.1  short transient receptor potential channel 3 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an upstream exon , compared to variant 1, resulting in a different 5' UTR and 5' coding region and translation initiation from an inframe, downstream ATG. The encoded protein (isoform b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AY865574, Y13758
      Consensus CDS
      CCDS3725.1
      UniProtKB/Swiss-Prot
      Q13507
      Related
      ENSP00000264811, OTTHUMP00000164084, ENST00000264811, OTTHUMT00000256709
      Conserved Domains (4) summary
      cd00204
      Location:46 – 180
      Blast Score: 157
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08344
      Location:194 – 256
      Blast Score: 298
      TRP_2; Transient receptor ion channel II
      TIGR00870
      Location:23 – 817
      Blast Score: 2250
      trp; transient-receptor-potential calcium channel protein
      pfam08016
      Location:395 – 677
      Blast Score: 151
      PKD_channel; Polycystin cation channel

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      122800183..122872909, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      118526892..118599598, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC079341.6 AAY40971.1
    genomic AC108930.3 None
    genomic CH471056.2 EAX05243.1
    genomic CS105827.1 CAJ01297.1
    mRNA AB255423.1 BAF76423.1
    mRNA AB255424.1 BAF76424.1
    mRNA AY865574.1 AAW62292.1
    mRNA BC093682.1 AAH93682.1
    mRNA BC093684.1 AAH93684.1
    mRNA BC143239.1 None
    mRNA X89068.1 CAA61448.1
    mRNA Y13758.1 CAA74083.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13507.3 GenPept UniProtKB/Swiss-Prot:Q13507
    Q4W5P7 GenPept UniProtKB/TrEMBL:Q4W5P7
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

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