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    Fbxl20 F-box and leucine-rich repeat protein 20 [ Mus musculus ]

    Gene ID: 72194, updated on 11-May-2012
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    Summary

    Official Symbol
    Fbxl20provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 20provided by MGI
    Primary source
    MGI:1919444
    Locus tag
    RP23-309H19.11-002
    See related
    Ensembl:ENSMUSG00000020883; Vega:OTTMUSG00000002913
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Scr; Fbl2; C86145; AI849362; AL117906; mKIAA4147; 2610511F20Rik; 4632423N09Rik; KIAA4147
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    Genomic context

    Location :
    11 D; 11
    Sequence :
    Chromosome: 11; NC_000077.6 (98082554..98149616, complement)
    See Fbxl20 in Epigenomics, MapViewer

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L19 Neighboring gene SH3 and cysteine rich domain 2 Neighboring gene mediator complex subunit 1 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene cyclin-dependent kinase 12

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Tang F, et al. PLoS One, 2011. PMID 21731673.
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750.
    3. Synaptic E3 ligase SCRAPPER in contextual fear conditioning: extensive behavioral phenotyping of Scrapper heterozygote and overexpressing mutant mice. Yao I, et al. PLoS One, 2011 Feb 24. PMID 21390313.
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693.

    See all (25) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The behavioral phenotypes of Scrapper mutant mice suggest that molecular degradation conferred by SCRAPPER play important roles in hippocampal-dependent fear memory formation.
      Title: Synaptic E3 ligase SCRAPPER in contextual fear conditioning: extensive behavioral phenotyping of Scrapper heterozygote and overexpressing mutant mice.
    2. SCRAPPER is synapse localized E3 ubiquitin ligase which binds/ubiquinates RIM1 to regulate synaptic transmission.
      Title: SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release.
    Submit: New GeneRIF Correction
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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:215210 BioGRID:205088 Cul1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:215210 BioGRID:228025 Rims1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:215210 BioGRID:203998 Skp1a    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:215210 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    F-box/LRR-repeat protein 20
    Names
    F-box/LRR-repeat protein 20
    scrapper
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028149.1 → NP_082425.1  F-box/LRR-repeat protein 20

      Status: VALIDATED

      Source sequence(s)
      AK028535, AK144786, AL591209, BB656518, CX211402
      Consensus CDS
      CCDS25339.1
      UniProtKB/Swiss-Prot
      Q9CZV8
      Related
      ENSMUSP00000099432, OTTMUSP00000002821, ENSMUST00000103143, OTTMUST00000005970
      Conserved Domains (2) summary
      cl15308
      Location:220 – 394
      Blast Score: 267
      AMN1; Antagonist of mitotic exit network protein 1
      cl02535
      Location:27 – 70
      Blast Score: 149
      F-box; F-box domain

    RefSeqs of Annotated Genomes: Build 38.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38 C57BL/6J

      Range
      98082554..98149616, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000033.1 Alternate Mm_Celera

      Range
      107737640..107804596, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_134030.1: Suppressed sequence

      Description
      NM_134030.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
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    Related Sequences

    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AL591205.13 CAM21260.1
    genomic AL591209.17 CAM20406.1
    genomic CH466556.1 EDL16116.1 mixed
      EDL16117.1 mixed
    genomic CH466556.1 EDL16116.1 mixed
      EDL16117.1 mixed
    mRNA AK012109.1 BAB28039.1 C57BL/6J
    mRNA AK028535.1 None C57BL/6J
    mRNA AK144786.1 BAE26066.1
    mRNA AK161566.1 None C57BL/6J
    mRNA AK206555.1 None
    mRNA AK207539.1 None
    mRNA AK209961.1 None
    mRNA AK220232.1 BAD90157.1
    mRNA BB656518.1 None
    mRNA BC004087.1 None FVB/N
    mRNA CX211402.1 None C57BL/6
    mRNA EF649694.1 ABU95014.1 C57BL/6J
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZV8.3 GenPept UniProtKB/Swiss-Prot:Q9CZV8
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
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