TRIP6 thyroid hormone receptor interactor 6 [Homo sapiens] - Gene

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Summary

Official Symbol: TRIP6provided by HGNC
Official Full Name: thyroid hormone receptor interactor 6provided by HGNC
Primary source: HGNC:12311
Locus tag: tcag7.1300
See related: Ensembl:ENSG00000087077; HPRD:04242; MIM:602933; Vega:OTTHUMG00000157029
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OIP1; OIP-1; ZRP-1; TRIP-6; TRIP6i2; MGC3837; MGC4423; MGC10556; MGC10558; MGC29959
Summary: This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 7q22

Sequence :: Chromosome: 7; NC_000007.13 (100464950..100471076)

See TRIP6 in Epigenomics, MapViewer

Chromosome 7 - NC_000007.13 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TRIP6 is engaged in cell proliferation, differentiation, transcription regulation and contributes to genome stability. [Review]
Title: Defining the role of TRIP6 in cell physiology and cancer.
TRIP6 is a nucleocytoplasmatic shuttle protein essential for the coordination of focal adhesion dynamics and transcriptional responses in lysophosphosphatidic (LPA) and NF-kappaB signaling.
Title: Defining the role of TRIP6 in cell physiology and cancer.
TRIP6 is an adaptor protein that regulates cell motility, antiapoptotic signaling and transcriptional activity. (Review)
Title: TRIP6: an adaptor protein that regulates cell motility, antiapoptotic signaling and transcriptional activity.
TRIP6 promotes Fas-mediated cell migration in apoptosis-resistant glioma cells. This effect is regulated via the Src-dependent phosphorylation of TRIP6 at Tyr-55.
Title: The adaptor protein TRIP6 antagonizes Fas-induced apoptosis but promotes its effect on cell migration.
IL-12 stimulates the OIP-1 gene expression through STAT-3 activation in CD4+ T cells.
Title: IL-12 stimulates the osteoclast inhibitory peptide-1 (OIP-1/hSca) gene expression in CD4+ T cells.
TRIP6 overexpression in colon tumors suggests its critical role in cancer progression.
Title: TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness.
OIP-1 inhibits measles virus nucleocapsid protein induced pagetic osteoclast formation/activity through suppression of RANK signaling
Title: Osteoclast inhibitory peptide-1 (OIP-1) inhibits measles virus nucleocapsid protein stimulated osteoclast formation/activity.
ZRP-1 plays a crucial role in coupling the cell-matrix/cell-cell-contact signals with Rho GTPase-mediated actin remodeling by localizing at cell-matrix and cell-cell contact sites.
Title: ZRP-1 controls Rho GTPase-mediated actin reorganization by localizing at cell-matrix and cell-cell adhesions.
ZRP-1 has a role in endoglin regulation of cytoskeletal organization
Title: Endoglin regulates cytoskeletal organization through binding to ZRP-1, a member of the Lim family of proteins.
AMPK phosphorylated TRIP6 in vitro at the N-terminus and the transcriptional co-activator properties of TRIP6 were enhanced by AMPK action.
Title: TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase.

Submit: New GeneRIF Correction See all (16)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q15654	P29972	AQP1	HPRD	PubMed
Q15654	P54259	ATN1	HPRD	PubMed
Q15654	P54253	ATXN1	HPRD	PubMed
Q15654	P56945	BCAR1	HPRD	PubMed
Q15654	CATSPER	CATSPER1	HPRD	PubMed
Q15654	Q9H5Z6	FAM124B	HPRD	PubMed
Q15654	Q5VWP2	FAM46C	HPRD	PubMed
Q15654	Q13643	FHL3	HPRD	PubMed
Q15654	Growth factor independent 1B	GFI1B	HPRD	PubMed
Q15654	P49639	HOXA1	HPRD	PubMed
Q15654	P31269	HOXA9	HPRD	PubMed
Q15654	Q12906	ILF3	HPRD	PubMed
Q15654	Q9H0B3	KIAA1683	HPRD	PubMed
Q15654	Q9HBW0	LPAR2	HPRD	PubMed
Q15654	O43639	NCK2	HPRD	PubMed
Q15654	Q14511	NEDD9	HPRD	PubMed
Q15654	Q8TEM1	NUP210	HPRD	PubMed
Q15654	Q14990	ODF1	HPRD	PubMed
Q15654	P50479	PDLIM4	HPRD	PubMed
Q15654	Q9Y2N3	POM121	HPRD	PubMed
Q15654	Q96I34	PPP1R16A	HPRD	PubMed
Q15654	P54646	PRKAA2	HPRD	PubMed
Q15654	Q05397	PTK2	HPRD	PubMed
Q15654	Q12923	PTPN13	HPRD	PubMed
Q15654	P49023	PXN	HPRD	PubMed
Q15654	Q9P2R6	RERE	HPRD	PubMed
Q15654	Q14160	SCRIB	HPRD	PubMed
Q15654	Q15797	SMAD1	HPRD	PubMed
Q15654	P18583	SON	HPRD	PubMed
Q15654	P12931	SRC	HPRD	PubMed
Q15654	Q96PV0	SYNGAP1	HPRD	PubMed
Q15654	P37243	THRB	HPRD	PubMed
Q15654	O60603	TLR2	HPRD	PubMed
Q15654	P67936	TPM4	HPRD	PubMed
Q15654	P18206	VCL	HPRD	PubMed
Q15654	Hypothetical protein BC014011		HPRD	PubMed
BioGRID:113056	BioGRID:106573	ACTA1	BioGRID	PubMed	Co-localization
BioGRID:113056	BioGRID:126390	AFAP1L1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113056	BioGRID:106854	AQP1	BioGRID	PubMed	Two-hybrid
BioGRID:113056	BioGRID:114934	BCAR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113056	BioGRID:125499	C5orf55	BioGRID	PubMed	Two-hybrid
BioGRID:113056	BioGRID:125556	CATSPER1	BioGRID	PubMed	Two-hybrid
BioGRID:113056	BioGRID:122934	FAM124B	BioGRID	PubMed	Two-hybrid
BioGRID:113056	BioGRID:120205	FAM46C	BioGRID	PubMed	Two-hybrid
BioGRID:113056	BioGRID:108566	FHL3	BioGRID	PubMed	Two-hybrid
BioGRID:113056	BioGRID:109438	HOXA1	BioGRID	PubMed	Two-hybrid
BioGRID:113056	BioGRID:109445	HOXA9	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:113056	BioGRID:109822	ILF3	BioGRID	PubMed	Two-hybrid
BioGRID:113056	BioGRID:119958	KCTD5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113056	BioGRID:123276	KIAA1683	BioGRID	PubMed	Two-hybrid
BioGRID:113056	BioGRID:114611	LPAR2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:113056	BioGRID:120527	MOB1A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113056	BioGRID:114020	NCK2	BioGRID	PubMed	Two-hybrid
BioGRID:113056	BioGRID:110816	NEDD9	BioGRID	PubMed	Two-hybrid
BioGRID:113056	BioGRID:116831	NUP210	BioGRID	PubMed	Two-hybrid
BioGRID:113056	BioGRID:111009	ODF1	BioGRID	PubMed	Reconstituted Complex
BioGRID:113056	BioGRID:111073	P4HB	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113056	BioGRID:115214	POM121	BioGRID	PubMed	Two-hybrid
BioGRID:113056	BioGRID:124414	PPP1R16A	BioGRID	PubMed	Two-hybrid
BioGRID:113056	BioGRID:111719	PTK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113056	BioGRID:111787	PXN	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113056	BioGRID:120477	RNMTL1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113056	BioGRID:112122	RPS14	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113056	BioGRID:108225	S1PR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113056	BioGRID:114754	SLC9A3R2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113056	BioGRID:112592	SRC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:113056	BioGRID:108354	STOM	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113056	BioGRID:115292	THRAP3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113056	BioGRID:113024	TPM4	BioGRID	PubMed	Two-hybrid
BioGRID:113056	BioGRID:246950	Thrb	BioGRID	PubMed	Two-hybrid
BioGRID:113056	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:113056	BioGRID:113257	VCL	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
interleukin-1 receptor binding	IDA Inferred from Direct Assay more info	PubMed
kinase binding	IPI Inferred from Physical Interaction more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
thyroid hormone receptor binding	NAS Non-traceable Author Statement more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cell adhesion	IEA Inferred from Electronic Annotation more info
focal adhesion assembly	NAS Non-traceable Author Statement more info	PubMed
positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
release of cytoplasmic sequestered NF-kappaB	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
cell junction	IEA Inferred from Electronic Annotation more info
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
focal adhesion	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with interleukin-1 receptor complex	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: thyroid receptor-interacting protein 6

Names: thyroid receptor-interacting protein 6; zyxin related protein 1; TR-interacting protein 6; OPA-interacting protein 1; thyroid hormone receptor interacting protein 6

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003302.2 → NP_003293.2 thyroid receptor-interacting protein 6

Status: REVIEWED

Source sequence(s)

BC004999, BM800083

Consensus CDS

CCDS5708.1

UniProtKB/Swiss-Prot

Q15654

Related

ENSP00000200457, OTTHUMP00000211326, ENST00000200457, OTTHUMT00000347151

Conserved Domains (3) summary

cd09350
Location:296 – 332
Blast Score: 186

LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)

cd09357
Location:399 – 461
Blast Score: 241

LIM3_Zyxin_like; The third LIM domain of Zyxin-like family

cl02475
Location:339 – 398
Blast Score: 283

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers.

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000007.13 Reference GRCh37.p5 Primary Assembly

Range

100464950..100471076

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000139.1 Alternate HuRef

Range

95095162..95101455

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CRA_TCAGchr7v2

Genomic

AC_000068.1 Alternate CRA_TCAGchr7v2

Range

99824555..99830681

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC011895.4 (109554..115585)	None
genomic	AF093836.1	AAD03037.1
genomic	AF312032.1	AAK21007.1
genomic	CH236956.1	EAL23817.1
genomic	CH471091.2	EAW76471.1
		EAW76472.1
		EAW76473.1
		EAW76474.1
mRNA	AB628085.1	BAK20496.1
mRNA	AB628086.1	BAK20497.1
mRNA	AB628087.1	BAK20498.1
mRNA	AB628088.1	BAK20499.1
mRNA	AF000974.1	AAB62222.1
mRNA	AF025437.1	AAC39557.1
mRNA	AJ001902.1	CAA05080.1
mRNA	AK056773.1	None
mRNA	AK291906.1	BAF84595.1
mRNA	AK309312.1	None
mRNA	BC002680.2	AAH02680.1
mRNA	BC004249.1	AAH04249.1
mRNA	BC004999.1	AAH04999.1
mRNA	BC021540.1	AAH21540.1
mRNA	BC028985.1	AAH28985.1
mRNA	BM800083.1	None
mRNA	CR749505.1	CAH18326.1
mRNA	L40374.1	AAC41740.1
other-genetic	DQ892893.2	ABM83819.1
other-genetic	DQ896140.2	ABM87139.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q15654.3	GenPept	UniProtKB/Swiss-Prot:Q15654
Q68D94	GenPept	UniProtKB/TrEMBL:Q68D94
Q71V88	GenPept	UniProtKB/TrEMBL:Q71V88