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    CCT3 chaperonin containing TCP1, subunit 3 (gamma) [ Homo sapiens (human) ]

    Gene ID: 7203, updated on 5-May-2013
    Official Symbol
    CCT3provided by HGNC
    Official Full Name
    chaperonin containing TCP1, subunit 3 (gamma)provided by HGNC
    Primary source
    HGNC:1616
    Locus tag
    RP11-443G18.6
    See related
    Ensembl:ENSG00000163468; HPRD:08969; MIM:600114; Vega:OTTHUMG00000024061
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCTG; PIG48; TRIC5; CCT-gamma; TCP-1-gamma
    Summary
    The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]
    Location :
    1q23
    Sequence :
    Chromosome: 1; NC_000001.10 (156278752..156308206, complement)
    See CCT3 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene chromosome 1 open reading frame 85 Neighboring gene von Hippel-Lindau tumor suppressor-like Neighboring gene TSSK6 activating co-chaperone Neighboring gene Rh family, B glycoprotein (gene/pseudogene) Neighboring gene chromosome 1 open reading frame 61 Neighboring gene microRNA 9-1

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description
    NP_005989.2 NP_002871.1 RAF1    BIND  PubMed C-RAF interacts with CCT3. 
    NP_005989.2 NP_002871.1 RAF1    BIND  PubMed RAF1 (C-Raf) interacts with CCT3 (hC87). 
    P49368 P49770 EIF2B2    HPRD  PubMed  
    P49368 Q13151 HNRNPA0    HPRD  PubMed  
    P49368 P11142 HSPA8    HPRD  PubMed  
    P49368 P68402 PAFAH1B2    HPRD  PubMed  
    P49368 P04049 RAF1    HPRD  PubMed  
    P49368 O60232 SSSCA1    HPRD  PubMed  
    P49368 P40337 VHL    HPRD  PubMed  
    P49368 P12956 XRCC6    HPRD  PubMed  
    BioGRID:113054 BioGRID:106549 ACACA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:128177 AGO3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:107776 ATF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:120375 ATG16L1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:122917 CAMKMT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:115827 CCT2    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:113054 BioGRID:115826 CCT4    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:113054 BioGRID:116603 CCT5    BioGRID  PubMed Co-fractionation 
    BioGRID:113054 BioGRID:107346 CCT6A    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:113054 BioGRID:115932 CCT6B    BioGRID  PubMed Co-fractionation 
    BioGRID:113054 BioGRID:115825 CCT7    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:113054 BioGRID:115933 CCT8    BioGRID  PubMed Co-fractionation 
    BioGRID:113054 BioGRID:107452 CDK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:107459 CDK9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:107506 CFTR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:107709 COPA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:123842 CTTNBP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:114030 CUL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:108257 EEF1G    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:114409 EIF2B2    BioGRID  PubMed Two-hybrid 
    BioGRID:113054 BioGRID:108374 EPS15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:575703 FAM86B2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:108472 FANCA    BioGRID  PubMed Two-hybrid 
    BioGRID:113054 BioGRID:117654 FBXO6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:117645 FBXW8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:108621 FN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:109142 GRB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:109698 IGBP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:109848 INPPL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:114995 ISG15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:109883 ITGA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:115114 KIAA0101    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:121540 LRRC47    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:111583 MAPK6    BioGRID  PubMed Two-hybrid 
    BioGRID:113054 BioGRID:110311 MARS    BioGRID  PubMed Co-fractionation 
    BioGRID:113054 BioGRID:124936 METTL18    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:129005 METTL20    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:117403 METTL21B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:128220 METTL21C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:125870 METTL23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:117369 MOB4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:204968 Mapk13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:110906 NOS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:110913 NOTCH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:126421 PACRG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:111086 PAFAH1B2    BioGRID  PubMed Two-hybrid 
    BioGRID:113054 BioGRID:111218 PEX14    BioGRID  PubMed Co-purification 
    BioGRID:113054 BioGRID:111507 PPP2CA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:111508 PPP2CB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:111512 PPP2R2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:111513 PPP2R2B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:111514 PPP2R2C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:120946 PPP2R2D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:111516 PPP2R4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:111523 PPP4C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:127414 PPP4R2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:111656 PSMA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:111657 PSMA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:111659 PSMA5    BioGRID  PubMed Co-fractionation 
    BioGRID:113054 BioGRID:111660 PSMA6    BioGRID  PubMed Co-fractionation 
    BioGRID:113054 BioGRID:111822 RAD21    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113054 BioGRID:111831 RAF1    BioGRID  PubMed Two-hybrid 
    BioGRID:113054 BioGRID:122136 RFWD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:117194 SH3BP4    BioGRID  PubMed Two-hybrid 
    BioGRID:113054 BioGRID:119602 SIRT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:115788 SSSCA1    BioGRID  PubMed Two-hybrid 
    BioGRID:113054 BioGRID:114011 STK24    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:112674 STRN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:118999 STRN3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:112810 TCP1    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:113054 BioGRID:115457 TRIM28    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:124390 UBASH3B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:113054 BioGRID:971434 US3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:113250 VARS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:113253 VAV2    BioGRID  PubMed Two-hybrid 
    BioGRID:113054 BioGRID:113255 VCAM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:113258 VCP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:113269 VHL    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113054 BioGRID:123245 WDR82    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113054 BioGRID:108822 XRCC6    BioGRID  PubMed Two-hybrid 

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    'de novo' posttranslational protein folding TAS
    Traceable Author Statement
    more info
     
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    protein folding TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    chaperonin-containing T-complex IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    microtubule IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    T-complex protein 1 subunit gamma
    Names
    T-complex protein 1 subunit gamma
    hTRiC5
    T-complex protein 1, gamma subunit
    TCP1 (t-complex-1) ring complex, polypeptide 5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008800.2NP_001008800.1  T-complex protein 1 subunit gamma isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform c), compared to isoform a.
      Source sequence(s)
      AK126400, AK293477, BG476176
      Consensus CDS
      CCDS30888.1
      UniProtKB/TrEMBL
      B3KX11
      UniProtKB/Swiss-Prot
      P49368
      Related
      ENSP00000357242, OTTHUMP00000231494, ENST00000368259, OTTHUMT00000387013
      Conserved Domains (2) summary
      cd03337
      Location:6487
      Blast Score: 1923
      TCP1_gamma; TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
      pfam00118
      Location:32486
      Blast Score: 1170
      Cpn60_TCP1; TCP-1/cpn60 chaperonin family
    2. NM_005998.4NP_005989.3  T-complex protein 1 subunit gamma isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AB208882, AK126400, BG476176
      Consensus CDS
      CCDS1140.2
      UniProtKB/TrEMBL
      B3KX11
      UniProtKB/Swiss-Prot
      P49368
      UniProtKB/TrEMBL
      Q59H77
      Related
      ENSP00000295688, OTTHUMP00000025735, ENST00000295688, OTTHUMT00000060602
      Conserved Domains (2) summary
      cd03337
      Location:6525
      Blast Score: 2184
      TCP1_gamma; TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
      pfam00118
      Location:33524
      Blast Score: 1308
      Cpn60_TCP1; TCP-1/cpn60 chaperonin family

    RNA

    1. NR_036564.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK126400, AK300765, BG476176
    2. NR_036565.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK126400, AK316387, BG476176

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p10 Primary Assembly

      Range
      156278752..156308206, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      127638812..127668494, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018912.1 Alternate CHM1_1.0

      Range
      162779581..162809056, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001008883.1: Suppressed sequence

      Description
      NM_001008883.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

      Supplemental Content

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