Slc39a4 solute carrier family 39 (zinc transporter), member 4 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Slc39a4provided by MGI
Official Full Name: solute carrier family 39 (zinc transporter), member 4provided by MGI
Primary source: MGI:1919277
See related: Ensembl:ENSMUSG00000063354
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ZIP4; AWMS2; AU041686; 1600025H15Rik

Genomic context

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Location :: 15 D3; 15

Sequence :: Chromosome: 15; NC_000081.6 (76612383..76616852, complement)

See Slc39a4 in Epigenomics, MapViewer

Chromosome 15 - NC_000081.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

These studies strongly suggest that wasting and lethality in acrodermatitis enteropathica patients reflects the loss-of-function of the intestine zinc transporter ZIP4, which leads to abnormal Paneth cell gene expression
Title: A mouse model of acrodermatitis enteropathica: loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity.
Cell migration assays revealed that RNAi knockdown of Zip4 in Hepa cells depressed in vitro migration whereas forced over-expression in Hepa cells and MCF-7 cells enhanced in vitro migration
Title: Zip4 (Slc39a4) expression is activated in hepatocellular carcinomas and functions to repress apoptosis, enhance cell cycle and increase migration.
ZIP4 physically interacts with tPA, correlating with an increased intracellular zinc influx and lysosomal sequestration after excitotoxin stimulation. Changes in prosurvival signals support the idea that this sequestration results in neuroprotection.
Title: Tissue plasminogen activator alters intracellular sequestration of zinc through interaction with the transporter ZIP4.
KLF4 is induced during zinc restriction and is a transcription factor involved in adaptive regulation of the zinc transporter ZIP4
Title: Krüppel-like factor 4 regulates adaptive expression of the zinc transporter Zip4 in mouse small intestine.
The processing of ZIP4 may represent a significant regulatory mechanism controlling its function.
Title: Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutations.
ZIP4 is induced by zinc deficiency in cultured mouse Hepa cells and is rapidly degraded in response to added zinc
Title: Novel zinc-responsive post-transcriptional mechanisms reciprocally regulate expression of the mouse Slc39a4 and Slc39a5 zinc transporters (Zip4 and Zip5).
that heterozygous mutations in the acrodermatitis gene Zip4 (Slc39a4) may be associated with a wider range of developmental defects than was previously appreciated, particularly when dietary zinc is limiting.
Title: The mouse acrodermatitis enteropathica gene Slc39a4 (Zip4) is essential for early development and heterozygosity causes hypersensitivity to zinc deficiency.
ZIP4 and ZIP5 have roles in the adaptive response to dietary zinc in mice
Title: The adaptive response to dietary zinc in mice involves the differential cellular localization and zinc regulation of the zinc transporters ZIP4 and ZIP5.
Zinc deficiency increased mZIP4 protein levels at the plasma membrane, and this was associated with increased zinc uptake.
Title: Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane.
results provide compelling evidence that ZIP4 is a zinc transporter that plays an important role in zinc homeostasis, a process that is defective in acrodermatitis enteropathica in humans
Title: The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice.

Submit: New GeneRIF Correction

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (Reporter) (1) 1 citation

Pathways from BioSystems

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Metal ion SLC transporters, organism-specific biosystem (from REACTOME)
Metal ion SLC transporters, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Mineral absorption, organism-specific biosystem (from KEGG)
Mineral absorption, organism-specific biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
Mineral absorption, conserved biosystem (from KEGG)
Mineral absorption, conserved biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
SLC-mediated transmembrane transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
Transmembrane transport of small molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds, organism-specific biosystem (from REACTOME)
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Zinc influx into cells by the SLC39 gene family, organism-specific biosystem (from REACTOME)
Zinc influx into cells by the SLC39 gene family, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Zinc transporters, organism-specific biosystem (from REACTOME)
Zinc transporters, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

Slc39a4 (e-PCR), detects polymorphism
- UniSTS:547106

AU041686 (e-PCR)
- UniSTS:160468

Homology

Homologs of the Slc39a4 gene: The Slc39a4 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
metal ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
zinc ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
cellular response to zinc ion starvation	IDA Inferred from Direct Assay more info	PubMed
cellular zinc ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
ion transport	IEA Inferred from Electronic Annotation more info
metal ion transport	IEA Inferred from Electronic Annotation more info
transmembrane transport	IEA Inferred from Electronic Annotation more info
transport	IEA Inferred from Electronic Annotation more info
zinc ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
zinc ion transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
cytoplasmic membrane-bounded vesicle	IDA Inferred from Direct Assay more info	PubMed
cytoplasmic membrane-bounded vesicle	ISO Inferred from Sequence Orthology more info
endosome	IDA Inferred from Direct Assay more info	PubMed
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc transporter ZIP4

Names: zinc transporter ZIP4; ZIP-4; mAWMS2; zrt- and Irt-like protein 4; activated in W/Wv mouse stomach 2; solute carrier family 39 member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028064.2 → NP_082340.1 zinc transporter ZIP4 precursor

Status: PROVISIONAL

Source sequence(s)

BC023498

Consensus CDS

CCDS27578.1

UniProtKB/Swiss-Prot

Q78IQ7

Related

ENSMUSP00000073134, ENSMUST00000073428

Conserved Domains (2) summary

COG0428
Location:510 – 622
Blast Score: 184

COG0428; Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]

pfam02535
Location:338 – 631
Blast Score: 330

Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000081.6 Reference GRCm38.p1 C57BL/6J

Range

76612383..76616852, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000037.1 Alternate Mm_Celera

Range

78105998..78110467, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01123557.1 (15211..19680)	None
genomic	AC122158.17 (88485..92956)	None	129/Sv
genomic	AC157566.6 (19536..24005)	None
genomic	CH466545.1	EDL29592.1	mixed
		EDL29593.1	mixed
mRNA	AB052762.1	BAC53795.1
mRNA	AK005535.1	None	C57BL/6J
mRNA	AK146977.1	BAE27581.1
mRNA	AK147107.1	BAE27679.1	C57BL/6J
mRNA	AK154089.1	BAE32367.1	NOD
mRNA	AK155467.1	BAE33279.1	NOD
mRNA	BC023498.1	AAH23498.1	FVB/N-3