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    C4A complement component 4A (Rodgers blood group) [ Homo sapiens ]

    Gene ID: 720, updated on 19-May-2012
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    Summary

    Official Symbol
    C4Aprovided by HGNC
    Official Full Name
    complement component 4A (Rodgers blood group)provided by HGNC
    Primary source
    HGNC:1323
    Locus tag
    DAMC-258G8.6
    See related
    Ensembl:ENSG00000244731; HPRD:00401; MIM:120810; Vega:OTTHUMG00000031186
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C4; RG; C4S; CO4; C4A2; C4A3; C4A4; C4A6; C4AD; CPAMD2; MGC164979
    Summary
    This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
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    Genomic context

    Location :
    6p21.3
    Sequence :
    Chromosome: 6; NC_000006.11 (31949834..31970457)
    See C4A in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene RD RNA binding protein Neighboring gene superkiller viralicidic activity 2-like (S. cerevisiae) Neighboring gene dom-3 homolog Z (C. elegans) Neighboring gene serine/threonine kinase 19 Neighboring gene cytochrome P450, family 21, subfamily A, polypeptide 1 pseudogene Neighboring gene tenascin XA (pseudogene) Neighboring gene serine/threonine kinase 19 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Association between copy number variation of complement component C4 and Graves' disease. Liu YH, et al. J Biomed Sci, 2011 Sep 26. PMID 21943165.
    2. Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations. Boteva L, et al. PLoS One, 2011. PMID 21857912.
    3. Complement component C4A and apolipoprotein A-I in plasmas as biomarkers of the severe, early-onset preeclampsia. Zhang H, et al. Mol Biosyst, 2011 Aug. PMID 21677994.
    4. Transcriptional repression of C4 complement by hepatitis C virus proteins. Banerjee A, et al. J Virol, 2011 May. PMID 21345967.
    5. Genotypic diversity of complement component C4 does not predict kidney transplant outcome. Wahrmann M, et al. J Am Soc Nephrol, 2011 Feb. PMID 21164027.

    See all (100) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Individuals with 4, 2, and 2 copies of C4, C4A and C4B genes, especially those with A2B2 polymorphism may associate with the development of Graves' disease
      Title: Association between copy number variation of complement component C4 and Graves' disease.
    2. Data show that in the UK cohort, total C4 GCN ranged from 2 to 6, with copy numbers from 0 to 4 observed for both C4A and C4B, while in the Spanish cohort, C4A GCN from 0 to 6 and C4B GCN from 0 to 5.
      Title: Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.
    3. The study shows the complement component C4A in the plasmas of sePE women is lower than the severe, late-onset PE women, and the Apolipoprotein A-I level is higher in sePE women than slPE women.
      Title: Complement component C4A and apolipoprotein A-I in plasmas as biomarkers of the severe, early-onset preeclampsia.
    4. C4 mRNA levels of the two isoforms (C4A and C4B) were significantly reduced in hepatocytes transfected with RNA from HCV genotype 1a or 2a.
      Title: Transcriptional repression of C4 complement by hepatitis C virus proteins.
    5. Data indicate that the deposition of both C4 and C3 showed a significant positive correlation with the serum concentration of Ficolin-3.
      Title: Functional analysis of Ficolin-3 mediated complement activation.
    6. The reduction in olfactory function in these hereditary angioedema cases seems to correlate with complement C4 and CH50 levels.
      Title: Evidence of impaired sense of smell in hereditary angioedema.
    7. not demonstrate that C4 gene copy number associates with transplant outcome
      Title: Genotypic diversity of complement component C4 does not predict kidney transplant outcome.
    8. The physiology and molecular basis of the Rodgers blood-group system is discussed. Review.
      Title: A review of the Chido/Rodgers blood group.
    9. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    10. Secretome analysis and protease inhibitor studies identified the secreted alkaline protease Alp1 as the central molecule responsible for the cleavage of human complement proteins C3, C4, and C5.
      Title: Secreted Aspergillus fumigatus protease Alp1 degrades human complement proteins C3, C4, and C5.
    Submit: New GeneRIF Correction See all (39)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    ?Systemic lupus erythematosus, susceptibility to or protection against

    Blood group, Rodgers

    C4a deficiency

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P0C0L4 P02652 APOA2    HPRD  PubMed  
    P0C0L4 Q16581 C3AR1    HPRD  PubMed  
    P0C0L4 P17927 CR1    HPRD  PubMed  
    P0C0L4 P01034 CST3    HPRD  PubMed  
    P0C0L4 Q9P296 GPR77    HPRD  PubMed  
    BioGRID:107181 BioGRID:106821 APC    BioGRID  PubMed Two-hybrid 
    BioGRID:107181 BioGRID:107853 CST3    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation of C3 and C5, organism-specific biosystem (from REACTOME)
      Activation of C3 and C5, organism-specific biosystemThe 3 pathways of complement activation converge on the cleavage of C3 by C3 convertases. C3 convertase cleaves C3 into C3a and C3b - a central step of complement activation. C3a remains in the flu...
    • Complement Activation, Classical Pathway, organism-specific biosystem (from WikiPathways)
      Complement Activation, Classical Pathway, organism-specific biosystemThe complement system is a biochemical cascade that helps, or ???complements???, the ability of antibodies to clear pathogens from an organism. It is part of the immune system called the innate immun...
    • Complement and coagulation cascades, organism-specific biosystem (from KEGG)
      Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
    • Complement and coagulation cascades, conserved biosystem (from KEGG)
      Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
    • Complement cascade, organism-specific biosystem (from REACTOME)
      Complement cascade, organism-specific biosystemThe complement system is a biochemical cascade, so named because it 'complements' the ability of antibodies to clear pathogens. It is part of the innate immune system. Complement system proteins circ...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Initial triggering of complement, organism-specific biosystem (from REACTOME)
      Initial triggering of complement, organism-specific biosystemComplement activation is due to a cascade of proteolytic steps, performed by serine protease domains in some of the components. Three different pathways of activation are distinguished triggered by t...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Regulation of Complement cascade, organism-specific biosystem (from REACTOME)
      Regulation of Complement cascade, organism-specific biosystemTwo inherent features of complement activation make its regulation very important: 1. There is an inherent positive feedback loop because the product of C3 activation forms part of an enzyme that cau...
    • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
      SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
    • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
      Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Staphylococcus aureus infection, conserved biosystem (from KEGG)
      Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Systemic lupus erythematosus, organism-specific biosystem (from KEGG)
      Systemic lupus erythematosus, organism-specific biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • Systemic lupus erythematosus, conserved biosystem (from KEGG)
      Systemic lupus erythematosus, conserved biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    complement activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    complement activation TAS
    Traceable Author Statement
    more info
    		  
    complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    innate immune response TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular region TAS
    Traceable Author Statement
    more info
    		  
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    complement C4-A
    Names
    complement C4-A
    acidic C4
    C4A anaphylatoxin
    Rodgers form of C4
    acidic complement C4
    C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011638.1 RefSeqGene

      Range
      5001..25624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_137

    mRNA and Protein(s)

    1. NM_001252204.1 → NP_001239133.1  complement C4-A isoform 2 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL645922, BC146673, DA918359, K02403
      UniProtKB/TrEMBL
      A6H8M8
      UniProtKB/Swiss-Prot
      P0C0L4
      Conserved Domains (10) summary
      cd00017
      Location:686 – 750
      Blast Score: 211
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      cd02896
      Location:996 – 1315
      Blast Score: 841
      complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
      COG2373
      Location:141 – 482
      Blast Score: 173
      COG2373; Large extracellular alpha-helical protein [General function prediction only]
      cd03584
      Location:1542 – 1696
      Blast Score: 627
      NTR_complement_C4; NTR/C345C domain, complement C4 subfamily; The NTR domain found in complement C4 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C4 is a key player in the activation of the component classical ...
      pfam00207
      Location:782 – 869
      Blast Score: 306
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:140 – 233
      Blast Score: 228
      A2M_N; MG2 domain
      pfam07677
      Location:1457 – 1524
      Blast Score: 270
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1051 – 1317
      Blast Score: 673
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:478 – 610
      Blast Score: 266
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam11974
      Location:20 – 90
      Blast Score: 90
      MG1; Alpha-2-macroglobulin MG1 domain

    2. NM_007293.2 → NP_009224.2  complement C4-A isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL645922, BC146673, DA918359, K02403
      Consensus CDS
      CCDS47404.1
      UniProtKB/TrEMBL
      A6H8M8
      UniProtKB/Swiss-Prot
      P0C0L4
      Related
      ENSP00000396688, OTTHUMP00000029266, ENST00000428956, OTTHUMT00000076364
      Conserved Domains (10) summary
      cd00017
      Location:686 – 750
      Blast Score: 210
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      cd02896
      Location:996 – 1315
      Blast Score: 841
      complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
      COG2373
      Location:141 – 482
      Blast Score: 173
      COG2373; Large extracellular alpha-helical protein [General function prediction only]
      cd03584
      Location:1588 – 1742
      Blast Score: 627
      NTR_complement_C4; NTR/C345C domain, complement C4 subfamily; The NTR domain found in complement C4 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C4 is a key player in the activation of the component classical ...
      pfam00207
      Location:782 – 869
      Blast Score: 306
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:140 – 233
      Blast Score: 228
      A2M_N; MG2 domain
      pfam07677
      Location:1481 – 1570
      Blast Score: 355
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1051 – 1317
      Blast Score: 673
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:478 – 610
      Blast Score: 265
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam11974
      Location:20 – 90
      Blast Score: 90
      MG1; Alpha-2-macroglobulin MG1 domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      31949834..31970457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.1 Reference GRCh37.p5 ALT_REF_LOCI_3

      Range
      3235415..3256039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.1 Reference GRCh37.p5 ALT_REF_LOCI_6

      Range
      3243624..3264248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1

      Range
      31736817..31746550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003403789.1 → XP_003403837.1  

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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL645922.12 (78321..98944) None
    genomic AL844853.23 CAI41869.1
    genomic AL929593.6 CAI41782.1
    genomic AY224378.1 AAP83249.1
    genomic AY379864.1 AAR89091.1
    genomic AY379866.1 AAR89093.1
    genomic AY379880.1 AAR89107.1
    genomic AY379881.1 AAR89108.1
    genomic AY379882.1 AAR89109.1
    genomic AY379883.1 AAR89110.1
    genomic AY379885.1 AAR89112.1
    genomic AY379887.1 AAR89114.1
    genomic AY379888.1 AAR89115.1
    genomic AY379889.1 AAR89116.1
    genomic AY379890.1 AAR89117.1
    genomic AY379891.1 AAR89118.1
    genomic AY379892.1 AAR89119.1
    genomic AY379893.1 AAR89120.1
    genomic AY379894.1 AAR89121.1
    genomic AY379895.1 AAR89122.1
    genomic AY379896.1 AAR89123.1
    genomic AY379897.1 AAR89124.1
    genomic AY379898.1 AAR89125.1
    genomic AY379899.1 AAR89126.1
    genomic AY379900.1 AAR89127.1
    genomic AY379902.1 AAR89130.1
    genomic AY379904.1 AAR89132.1
    genomic AY379906.1 AAR89134.1
    genomic AY379908.1 AAR89136.1
    genomic AY379912.1 AAR89139.1
    genomic AY379913.1 AAR89140.1
    genomic AY379914.1 AAR89142.1
    genomic AY379915.1 AAR89141.1
    genomic AY379916.1 AAR89144.1
    genomic AY379917.1 AAR89143.1
    genomic AY379918.1 AAR89145.1
    genomic AY379919.1 AAR89146.1
    genomic AY379920.1 AAR89148.1
    genomic AY379921.1 AAR89147.1
    genomic AY379922.1 AAR89150.1
    genomic AY379923.1 AAR89149.1
    genomic AY379928.1 AAR89155.1
    genomic AY379929.1 AAR89156.1
    genomic AY379930.1 AAR89157.1
    genomic AY379931.1 AAR89158.1
    genomic AY379932.1 AAR89159.1
    genomic AY379933.1 AAR89160.1
    genomic AY379934.1 AAR89161.1
    genomic AY379935.1 AAR89162.1
    genomic AY379960.1 AAR89164.1
    genomic AY379961.1 AAR89165.1
    genomic AY379962.1 AAR89166.1
    genomic AY379963.1 AAR89167.1
    genomic AY379964.1 AAR89168.1
    genomic AY379965.1 AAR89169.1
    genomic AY379966.1 AAR89170.1
    genomic AY379967.1 AAR89171.1
    genomic AY379968.1 AAR89172.1
    genomic AY379969.1 AAR89173.1
    genomic AY379970.1 AAR89174.1
    genomic AY379971.1 AAR89175.1
    genomic CR753845.11 (27181..47805) None
    genomic CR936924.2 CAQ07657.1
    genomic L26261.1 AAA20121.2
    genomic M14823.1 AAA35617.1
    genomic M14824.1 AAA52292.1
    genomic M59815.1 AAA51855.1
    genomic M59816.1 AAA51855.1
    genomic S58715.1 AAB26211.2
    genomic U07851.1 AAB63418.1
    genomic U07852.1 AAB63419.1
    genomic U07853.1 AAB63420.1
    genomic U07855.1 AAB63422.1
    genomic X77491.1 CAA54627.1
    mRNA AB209989.1 BAE06071.1
    mRNA AI065121.1 None
    mRNA AK293191.1 BAG56731.1
    mRNA AK293364.1 BAH11494.1
    mRNA BC012372.2 AAH12372.2
    mRNA BC016933.1 None
    mRNA BC063289.1 AAH63289.1
    mRNA BC144546.1 AAI44547.1
    mRNA BC146673.1 AAI46674.1
    mRNA BC146849.1 AAI46850.1
    mRNA BC151204.1 AAI51205.1
    mRNA BC171786.1 AAI71786.1
    mRNA BX452374.2 None
    mRNA K00830.1 AAA36229.1
    mRNA K02403.1 AAB59537.1
    mRNA S81585.1 AAB36122.1
    mRNA V00502.1 CAA23760.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C0L4.1 GenPept UniProtKB/Swiss-Prot:P0C0L4
    Q30211 GenPept UniProtKB/TrEMBL:Q30211
    Q4LE82 GenPept UniProtKB/TrEMBL:Q4LE82
    Q5JNX2 GenPept UniProtKB/TrEMBL:Q5JNX2
    Q6P4R1 GenPept UniProtKB/TrEMBL:Q6P4R1
    Q6U2E0 GenPept UniProtKB/TrEMBL:Q6U2E0
    Q6U2E5 GenPept UniProtKB/TrEMBL:Q6U2E5
    Q6U2E7 GenPept UniProtKB/TrEMBL:Q6U2E7
    Q6U2E8 GenPept UniProtKB/TrEMBL:Q6U2E8
    Q6U2F0 GenPept UniProtKB/TrEMBL:Q6U2F0
    Q6U2F3 GenPept UniProtKB/TrEMBL:Q6U2F3
    Q6U2F4 GenPept UniProtKB/TrEMBL:Q6U2F4
    Q6U2F6 GenPept UniProtKB/TrEMBL:Q6U2F6
    Q6U2F8 GenPept UniProtKB/TrEMBL:Q6U2F8
    Q6U2I5 GenPept UniProtKB/TrEMBL:Q6U2I5
    Q6U2K2 GenPept UniProtKB/TrEMBL:Q6U2K2
    Q6U2L1 GenPept UniProtKB/TrEMBL:Q6U2L1
    Q6U2L7 GenPept UniProtKB/TrEMBL:Q6U2L7
    Q6U2L9 GenPept UniProtKB/TrEMBL:Q6U2L9
    Q6U2M5 GenPept UniProtKB/TrEMBL:Q6U2M5
    Q6XMI6 GenPept UniProtKB/TrEMBL:Q6XMI6
    Q96EG2 GenPept UniProtKB/TrEMBL:Q96EG2
    Q9UM89 GenPept UniProtKB/TrEMBL:Q9UM89
    Q9UMV1 GenPept UniProtKB/TrEMBL:Q9UMV1
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    Additional Links

    Additional Links

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